Abstract:
PURPOSE:To report prostate-specific antigen (PSA) relapse-free survival and treatment-related toxicity outcomes after combining high-dose-rate (HDR) brachytherapy with external beam radiotherapy (EBRT) for patients with clinically localized prostate cancer. METHODS AND MATERIALS:Between 1998 and 2009, 229 patients were treated with HDR brachytherapy followed 3 weeks later by supplemental EBRT. The HDR brachytherapy boost consisted of three fractions of (192)Ir (5.5-7.5Gy per fraction), and EBRT consisted of intensity-modulated radiotherapy delivering an additional 45.0-50.4Gy directed to the prostate gland and seminal vesicles. Median follow-up was 61 months. RESULTS:Seven-year PSA relapse-free survival for low-, intermediate-, and high-risk patients were 95%, 90%, and 57%, respectively (p<0.001). Among high-risk patients treated with biological equivalent doses in excess of 190Gy, 7-year PSA relapse-free survival was 81%. In multivariate analysis, Gleason scores of ≥8 predicted for increased risk of biochemical failure, whereas the use of short-term neoadjuvant androgen deprivation therapy did not influence tumor-control outcomes even among intermediate- or high-risk patients. Seven-year incidence of distant metastases for low-, intermediate-, and high-risk patients were 5%, 3%, and 17%, respectively. Seven-year incidence of late Grade 2 and 3 genitourinary toxicities were 22.1% and 4.9%, respectively and the 7-year incidence of Grade 2 and 3 gastrointestinal toxicities were 1% and 0.4%, respectively. CONCLUSION:HDR prostate brachytherapy in conjunction with supplemental EBRT results in excellent biochemical relapse-free survival rates with a low incidence of severe late genitourinary or gastrointestinal toxicities. The use of short-term neoadjuvant androgen deprivation did not influence long-term biochemical tumor control in this cohort.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Kotecha R,Yamada Y,Pei X,Kollmeier MA,Cox B,Cohen GN,Zaider M,Zelefsky MJdoi
10.1016/j.brachy.2012.05.003subject
Has Abstractpub_date
2013-01-01 00:00:00pages
44-9issue
1eissn
1538-4721issn
1873-1449pii
S1538-4721(12)00166-3journal_volume
12pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:To compare a standard radio-oncological and a surgical biochemical failure definition after combined-modality radiation therapy (CRT) in men with intermediate- and high-risk prostate cancer. METHODS:425 men were treated with external beam radiotherapy (59.4 Gy, 33 fractions) and 125J seed-brachytherapy (S-BT, ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.09.001
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate lumpectomy followed by interstitial brachytherapy as an acceptable salvage therapy for women who have developed localized recurrence of breast cancer after conservation surgery and postoperative external radiotherapy. METHODS AND MATERIALS:Between 1/1998 and 10/2006, 21 patients with T0 or T1 in-br...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.12.001
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and feasibility of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice. METHODS AND MATERIALS:From January 2010 to February 2015, 18 consecutive patients diagnosed with locally advanced, nonmetastatic, inope...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.05.004
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:GammaTile cesium-131 (131Cs) permanent brain implant has received Food and Drug Administration (FDA) clearance as a promising treatment for certain brain tumors. Our center was the first institution in the United States after FDA clearance to offer the clinical use of GammaTile brachytherapy outside of a clinic...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.12.005
更新日期:2021-01-21 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mol...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.003
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To report the preliminary results of transabdominal ultrasound (TAUS)-guided brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS:Twenty-nine patients with cervical cancer Stage IB-IVA according to The International Federation of Gynecology and Obstetrics staging were treated by radical radiotherapy fr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.11.001
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:In this study, computer modeling was used to compare the relative doses with the bladder, rectum, and bowel when two different brachytherapy modalities were used to treat cervical cancer with a tandem and ovoid applicator. A standard high-dose rate (HDR) (192)Ir treatment plan was compared with a "mixed-source"...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2010.08.009
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.09.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:HDRILBT is one of the best methods of palliation for advanced esophageal cancer (AEC) by improving dysphagia-free survival (DFS) and overall survival (OS). This study examines if the addition of EBRT would further improve the outcome by improving DFS in AEC. METHODS AND MATERIALS:Patients with inoperable AEC w...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.brachy.2004.09.004
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Brachytherapy (BrT) is a standard treatment for low-risk to favorable-intermediate-risk prostate cancer but is a relative contraindication for patients with obstructive symptoms. We aimed to assess the feasibility and urinary toxicity of a minimal photovaporization (mPVP) before implantation. MATERIALS AND MET...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.08.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To develop a dose verification tool for high-dose-rate interstitial brachytherapy treatment planning in accelerated partial breast irradiation. METHODS AND MATERIALS:We have developed a software tool for interstitial brachytherapy treatment planning assessment. The software contains a database of seven (192)Ir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.008
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To present recommendations for the use of brachytherapy (BT) in patients with soft tissue sarcoma (STS). METHODS:A group of practitioners with expertise and experience in sarcoma BT formulated recommendations for BT in STS based on clinical experience and literature review. RESULTS:The indications for adjuvan...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2012.12.002
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Dose escalation using high-dose-rate brachytherapy (HDR-BT) is an established treatment method for prostate cancer. First, long-term results were previously published (specific Kiel method). This study aims to evaluate 10-/15-year outcomes of Kiel Protocol 1 (1986-1992). METHODS AND MATERIALS:Conformal externa...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2013.11.002
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:Currently, there are high dose rate afterloaders available that can drive two different radioactive sources simultaneously. The source-source and source-cable attenuations are not taken into account by current planning systems. The purpose of this work is to characterize these effects and their overall impact o...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.03.007
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To assess the feasibility and tumor outcome of re-irradiation with low-dose-rate brachytherapy for macroscopic local recurrences after radical prostatectomy (RP) followed by adjuvant or salvage external beam radiation therapy (EBRT). METHODS AND MATERIALS:Between 2011 and 2018, five men with histologically pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.07.001
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:While the noninvasive breast brachytherapy (NIBB) treatment procedure, known as AccuBoost, for breast cancer patients is well established, the treatment quality can be improved by the efficiency of the workflow delivery. A formalized approach evaluated the current workflow through failure modes and effects anal...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.01.007
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To develop a safe and robust workflow for yttrium-90 (Y-90) radioembolization procedures in a multidisciplinary team environment. METHODS AND MATERIALS:A generalized Define-Measure-Analyze-Improve-Control (DMAIC)-based approach to process improvement was applied to a Y-90 radioembolization workflow. In the fir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.001
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Low-dose-rate brachytherapy using iodine-125 seeds is a highly efficacious treatment for low-risk prostate cancer. We propose a bioeffect model may be used to target an ablative dose to the tumor with a lower, therapeutic dose to low-risk regions to maintain high rates of tumor control with reduced toxicity. We...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brachy.2013.04.008
更新日期:2013-11-01 00:00:00
abstract::MRI produces better soft tissue contrast than does ultrasonography or computed tomography for visualizing male pelvic anatomy and prostate cancer. Better visualization of the tumor and organs at risk could allow better conformation of the dose to the target volumes while at the same time minimizing the dose to critica...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.11.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:In this planning study, we investigated the dosimetric benefit of repeat CT-based treatment planning at each fraction vs. the use of a single CT-based treatment plan for all fractions for high-dose-rate endorectal brachytherapy (HDREBT) for rectal cancer. METHODS AND MATERIALS:We included 11 patients that rece...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.011
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Patients with large prostate glands are underrepresented in clinical trials incorporating brachytherapy due to concerns for excessive toxicity. We sought to compare health-related quality of life (HRQOL) outcomes between small (<60 cc) and large (≥60 cc) prostates treated with high-dose-rate brachytherapy (HDR-...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.08.009
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe in detail British Columbia (BC) Cancer Agency (BCCA) Provincial Prostate Brachytherapy (PB) Quality Assurance (QA) Program. METHODS AND MATERIALS:The BCCA PB Program was established in 1997. It operates as one system, unified and supported by electronic and information systems, making it a single P...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.006
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy boost is a treatment of intermediate- to high-risk prostate cancer, but long-term clinical outcome data are sparse. We report long-term survival and toxicity data in a cohort of patients treated in a single institution. METHODS:Between 1998 and 2004, 654 patients with localiz...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.01.013
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To quantify the percentage doses received by salivary glands (SGDs) in head and neck interstitial brachytherapy (BT). METHODS AND MATERIALS:The study included 43 patients who underwent high-dose rate iridium-192 implant for oral cavity and oropharyngeal lesions treated with BT as a boost. BT dose varied with d...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2010.03.001
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to compare the results of the combined external beam radiotherapy (EBRT) with iodine-125 seed brachytherapy vs. brachytherapy alone for prostate cancer treatment in patients with intermediate and high risk of disease recurrence. METHODS AND MATERIALS:Ninety-six patients were treated f...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.07.011
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Treatment of locally advanced cervical cancer in patients with a renal graft requires precautions. The graft is usually in a pelvic position, close to the clinical target volume (CTV). Preserving the graft while ensuring local control is a challenge we have faced in two occasions. We report our experience. MET...
journal_title:Brachytherapy
pub_type: 社论
doi:10.1016/j.brachy.2013.11.003
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to retrospectively observe and analyze the long-term treatment outcomes for a total of 952 esophageal cancer patients who were treated with (252)Cf neutron brachytherapy (NBT) in combination with external beam radiotherapy (EBRT). METHODS AND MATERIALS:From November 2001 to March 2012...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.03.004
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To determine the relationship between dosimetric parameters obtained on postimplantation Day 0 and biochemical relapse-free survival (bRFS) in patients treated with (125)I transperineal interstitial permanent prostate brachytherapy (TIPPB). METHODS:Two-hundred twenty men with low-risk (n=155, 70.4%), low-vo...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.04.005
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of the single-energy metal artifact reduction (SEMAR) technique for improving the accuracy of I-125 seed identification in postimplant computed tomography (CT) after prostate brachytherapy. METHODS AND MATERIALS:Postimplant CT images of 40 patients treated with I-125 prostate brac...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.07.006
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. METHODS AND MATERIALS:For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (ConvICBT), Image-guided ICBT (IGICBT), intra...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.10.002
更新日期:2016-01-01 00:00:00