Abstract:
:Hypertension is one of the major predisposing factors for neurodegenerative disease characterized with activated renin-angiotensin system (RAS) in both periphery and brain. Vitamin D (VitD) is recently recognized as a pleiotropic hormone with strong neuroprotective properties. While multiple lines of evidence suggest that VitD can act on RAS, the evidence concerning the crosstalk between VitD and RAS in the brain is limited. Therefore, this study aims to evaluate whether VitD can modulate brain RAS to trigger neuroprotective actions in the brain of spontaneously hypertensive rats (SHR). Our data showed that calcitriol treatment induced VDR expression and inhibited neural death in the prefrontal cortex of SHR. Sustained calcitriol administration also inhibited microglia M1 polarization, but enhanced M2 polarization, accompanied with decreased expression of proinflammatory cytokines. We then further explored the potential mechanisms and showed that SHR exhibited overactivated classical RAS with increased expression of angiotensin II (Ang II) receptor type 1 (AT1), angiotensin converting enzyme (ACE) and Ang II production, whereas the counteracting arm of traditional RAS, ACE2/Ang(1-7)/MasR, was impaired in the SHR brain. Calcitriol nonsignificantly suppressed AT1 and ACE but markedly reduced Ang II formation. Intriguingly, calcitriol exerted pronouncedly impact on ACE2/Ang(1-7)/MasR axis with enhanced expression of ACE2, MasR and Ang(1-7) generation. Meanwhile, calcitriol ameliorated the overactivation of NADPH-oxidase (Nox), the downstream of RAS, in SHR, and also mitigated oxidative stress. In microglial (BV2) cells, we further found that calcitriol induced ACE2 and MasR with no significant impact on ACE and AT1. In accordance, calcitriol also attenuated Ang II-induced Nox activation and ROS production, and shifted the microglia polarization from M1 to M2 phenotype. However, co-treatment with A779, a specific MasR antagonist, abrogated the antioxidant and neuroimmune modulating actions of VitD. These findings strongly indicate the involvement of ACE2/Ang(1-7)/MasR pathway in the neuroprotective mechanisms of VitD in the hypertensive brain.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Cui C,Xu P,Li G,Qiao Y,Han W,Geng C,Liao D,Yang M,Chen D,Jiang Pdoi
10.1016/j.redox.2019.101295subject
Has Abstractpub_date
2019-09-01 00:00:00pages
101295issn
2213-2317pii
S2213-2317(19)30694-9journal_volume
26pub_type
杂志文章相关文献
Redox Biology文献大全abstract::Glioblastoma (GBM) is the most common and most aggressive brain tumor, associated with high levels of reactive oxidative species (ROS) due to metabolic and signaling aberrations. High ROS levels are detrimental to cells, but it remains incompletely understood how cancer cells cope with the adverse effects. Here we sho...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101578
更新日期:2020-07-01 00:00:00
abstract::Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have hi...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2014.11.006
更新日期:2015-01-01 00:00:00
abstract::Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts with influenza A virus (IAV) hemagglutinin (HA), and this interaction is required for efficient oxidative folding of...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2019.101129
更新日期:2019-04-01 00:00:00
abstract::Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title:Redox biology
pub_type: 临床试验,杂志文章
doi:10.1016/j.redox.2016.12.014
更新日期:2017-04-01 00:00:00
abstract::Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to inves...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101815
更新日期:2021-01-01 00:00:00
abstract::Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypothesized that the u...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2016.05.001
更新日期:2016-08-01 00:00:00
abstract::Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events that modulate the immune response in neutrophils. When activated, neu...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2016.06.003
更新日期:2016-10-01 00:00:00
abstract::This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), a...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2020.101721
更新日期:2020-10-01 00:00:00
abstract::Activity-induced nitric oxide (NO) imbalance and "nitrosative stress" are proposed mechanisms of disrupted Ca(2+) homeostasis in atrophic skeletal muscle. We thus mapped S-nitrosylated (SNO) functional muscle proteins in healthy male subjects in a long-term bed rest study (BBR2-2 Study) without and with exercise as co...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2013.10.006
更新日期:2013-10-28 00:00:00
abstract::Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we fou...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.05.025
更新日期:2017-10-01 00:00:00
abstract::For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China,...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2013.09.003
更新日期:2013-09-17 00:00:00
abstract::Ferroptosis is a newly defined form of cell death induced by iron-dependent accumulation of lethal lipid peroxidation. Ferroptosis represent a therapeutic strategy to suppress therapy-resistant cancer cells with more property of epithelial-mesenchymal transition (EMT). However, epigenetic reprogramming of EMT has been...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101697
更新日期:2020-10-01 00:00:00
abstract::Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 μg per cubic meter was associated with a 76% increase in the ris...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2019.101161
更新日期:2019-04-01 00:00:00
abstract::The NADPH oxidase reaction produces protons. In the case of the NADPH oxidase, NOX2, activity depends on secretion of these protons and is inhibited by blockade of the voltage-gated proton channel (Hv1). Duox1 and Duox2 activities similarly produce intracellular protons but synthesize hydrogen peroxide directly instea...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2019.101346
更新日期:2020-01-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) is an important anti-inflammatory, antioxidative and cytoprotective enzyme that is regulated by the activation of the major transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In the present study, six stilbene derivatives isolated from Rheum undulatum L. were assessed for...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2014.02.001
更新日期:2014-02-18 00:00:00
abstract::Increased permeability of the intestinal barrier is proposed as an underlying factor for obesity-associated pathologies. Consumption of high fat diets (HFD) is associated with increased intestinal permeabilization and increased paracellular transport of endotoxins which can promote steatosis and insulin resistance. Th...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.11.002
更新日期:2018-04-01 00:00:00
abstract::Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration. Recently, we reported that abrogation of Nrf2/antioxidant signaling promotes oxidative stress and im...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101492
更新日期:2020-07-01 00:00:00
abstract::Emerging evidence suggests that oroxylin A exhibits antitumor effects by inducing cell apoptosis. However, the involved molecular mechanisms have not been elucidated. Here we report that the apoptosis induced by oroxylin A was dependent on p62-mediated activation of caspase-8 in hepatocellular carcinoma cells. Further...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2019.101392
更新日期:2020-01-01 00:00:00
abstract::The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER) associated heme protein, is known to play important roles in protection against oxidative and chemical stress by degrading free heme released from degradation of heme proteins. In this study we show that induced expression of HO-1 by sub...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2013.07.004
更新日期:2013-07-23 00:00:00
abstract::The massive production and activation of myofibroblasts (MFB) is key to the development of liver fibrosis. In many studies, it has been proven that hepatocytes are an important part of MFB, and can be transformed into MFB through epithelial-mesenchymal transition (EMT) during hepatic fibrogenesis. In our previous stud...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101600
更新日期:2020-09-01 00:00:00
abstract::Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been li...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2020.101505
更新日期:2020-04-01 00:00:00
abstract::Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present stud...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.06.007
更新日期:2017-10-01 00:00:00
abstract::Vascular peroxidase 1 (VPO1) is a member of the peroxidase family which aggravates oxidative stress by producing hypochlorous acid (HOCl). Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADM...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.02.022
更新日期:2017-08-01 00:00:00
abstract::We previously reported that oncogenic KRAS activation of the PI3K/AKT pathway stimulates the remaining wild-type HRAS and NRAS proteins in a manner dependent upon both eNOS expression and C118 in HRAS and NRAS, which promoted tumor growth. Interestingly however, we recently found that loss of wild-type HRAS, NRAS, and...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.09.023
更新日期:2015-08-01 00:00:00
abstract::Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration. However, bioavailable levels of H2S in its various biochemica...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2018.01.007
更新日期:2018-05-01 00:00:00
abstract::PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2018.03.016
更新日期:2018-07-01 00:00:00
abstract::Selenium-binding protein 1 (SELENBP1) has recently been reported to catalyse the oxidation of methanethiol, an organosulfur compound produced by gut microbiota. Two of the reaction products of methanethiol oxidation, hydrogen peroxide and hydrogen sulphide, serve as signalling molecules for cell differentiation. Indee...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2018.11.004
更新日期:2019-01-01 00:00:00
abstract::Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2017.04.040
更新日期:2017-08-01 00:00:00
abstract::Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.12.006
更新日期:2018-05-01 00:00:00
abstract::Ozone (O3) is a serious public health concern. Recent findings indicate that the damaging health effects of O3 extend to multiple systemic organ systems. Herein, we hypothesize that O3 inhalation will cause downstream alterations to the liver. To test this, male Sprague-Dawley rats were exposed to 0.5ppm O3 for 8h/day...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2013.11.006
更新日期:2014-01-01 00:00:00