Abstract:
:DNA-encoded libraries of chemically synthesized compounds are an important small molecule screening technology. The synthesis of encoded compounds in solution is currently restricted to a few DNA-compatible and water-tolerant reactions. Encoded compound synthesis of short DNA-barcodes covalently connected to solid supports benefits from a broad range of choices of organic solvents. Here, we show that this encoded chemistry approach allows for the synthesis of DNA-coupled isoquinolones by an Yb(iii)-mediated Castagnoli-Cushman reaction under anhydrous reaction conditions and for the synthesis of highly substituted pyrrolidines by Ag(i)-mediated 1,3-dipolar azomethine ylide cycloaddition. An encoding scheme for these DNA-barcoded compounds based on a DNA hairpin is demonstrated.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Potowski M,Kunig VBK,Losch F,Brunschweiger Adoi
10.1039/c9md00042asubject
Has Abstractpub_date
2019-02-26 00:00:00pages
1082-1093issue
7eissn
2040-2503issn
2040-2511pii
c9md00042ajournal_volume
10pub_type
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