Cytoplasmic poly(ADP-ribose) polymerase associated with free messenger ribonucleoprotein particles in rat brain.

abstract：:Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

journal_title：Journal of neurochemistry

authors： Quast U,Brenner O

更新日期：1983-08-01 00:00:00

abstract：:It is necessary for the cell-cycle machinery of neurons to be suppressed to promote differentiation and maintenance of their terminally differentiated state. Reactivation of the cell cycle in response to neurotoxic insults leads to neuronal cell death and some cell-cycle-related proteins contribute to the process. p27...

journal_title：Journal of neurochemistry

authors： Jaiswal S,Sharma P

更新日期：2017-02-01 00:00:00

abstract：:Significant progress has been made in the identification of intrinsic and extrinsic factors involved in the development of nervous system. It is remarkable that the establishment and maintenance of the asymmetrical architecture of a neuron is coordinated by a limited repertoire of signalling machineries. However, the ...

journal_title：Journal of neurochemistry

authors： Hur EM,Kim KT

更新日期：2007-05-01 00:00:00

abstract：:Tubulin tyrosine ligase catalyzes the reversible addition of tyrosine to the C-terminus of tubulin alpha chains. By using ligase and carboxypeptidase A in conjunction, we have previously shown that brain cytoplasmic tubulin exists in three forms: 15-40% already has C-terminal tyrosine, another 10-30% can accept additi...

journal_title：Journal of neurochemistry

authors： Nath J,Flavin M

更新日期：1980-09-01 00:00:00

abstract：:The chemokine IL-8 is known to be synthesized by glial cells in the brain. It has traditionally been shown to have an important role in neuroinflammation but recent evidence indicates that it may also be involved in rapid signaling in neurons. We investigated how IL-8 participates in rapid neuronal signaling by using ...

journal_title：Journal of neurochemistry

authors： Puma C,Danik M,Quirion R,Ramon F,Williams S

更新日期：2001-09-01 00:00:00

abstract：:Equilibrium binding of [3H]dihydromorphine was assayed in brain regions of young and aged male F344 rats. Young rats had significantly higher receptor densities than old rats in the frontal poles, anterior cortex, and striatum. In the frontal poles, the decline in receptor concentration with age was accompanied by a s...

journal_title：Journal of neurochemistry

authors： Messing RB,Vasquez BJ,Samaniego B,Jensen RA,Martinez JL Jr,McGaugh JL

更新日期：1981-02-01 00:00:00

abstract：:Studies suggest that activation of phosphoinositide 3-kinase-Akt may protect against neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of increased Akt activation, and hyperphosphorylation of critical Akt substrates in AD brain, which link to AD pathogenesis, suggesting that treatment...

journal_title：Journal of neurochemistry

authors： Griffin RJ,Moloney A,Kelliher M,Johnston JA,Ravid R,Dockery P,O'Connor R,O'Neill C

更新日期：2005-04-01 00:00:00

abstract：:To investigate the role of the retinoblastoma protein pRB in neuronal differentiation, we have measured the accumulation of hypophosphorylated pRB in PC12 cells stimulated by nerve growth factor (NGF). NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cy...

journal_title：Journal of neurochemistry

authors： Li H,Kawasaki H,Nishida E,Hattori S,Nakamura S

更新日期：1996-06-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) has both soluble (S-COMT) and membrane-bound (MB-COMT) isoforms. A specific COMT antibody was used in immunohistochemical and confocal co-localization studies to explore the distribution of COMT in general in normal mice and MB-COMT in particular, in an S-COMT deficient mouse line. ...

journal_title：Journal of neurochemistry

authors： Myöhänen TT,Schendzielorz N,Männistö PT

更新日期：2010-06-01 00:00:00

abstract：:Astrocytes remove glutamate from the synaptic cleft via specific transporters, and impaired glutamate reuptake may promote excitotoxic neuronal injury. In a model of viral encephalomyelitis caused by neuroadapted Sindbis virus (NSV), mice develop acute paralysis and spinal motor neuron degeneration inhibited by the AM...

journal_title：Journal of neurochemistry

authors： Prow NA,Irani DN

更新日期：2008-05-01 00:00:00

abstract：:Ganglioside GM1, tritiated at the level of the long chain base (sphingosine) [( Sph-3H]GM1), sialic acid (N-acetylneuraminic acid) [( NeuAc-3H]GM1), or terminal galactose [( Gal-3H]GM1) was supplied to cerebellar granule cells differentiated in vitro, and its metabolic processing was followed with pulse time. Using [S...

journal_title：Journal of neurochemistry

authors： Riboni L,Tettamanti G

更新日期：1991-12-01 00:00:00

abstract：:We have recently shown that disrupting the expression and post-synaptic clustering of gephyrin in cultured hippocampal pyramidal cells, by either gephyrin RNAi (RNA interference) or over-expression of a dominant negative gephyrin-enhanced green fluorescent protein (EGFP) fusion protein, leads to decreased number of po...

journal_title：Journal of neurochemistry

authors： Yu W,De Blas AL

更新日期：2008-02-01 00:00:00

abstract：:The capacity of D1 and D2 agonists and antagonists to regulate the in vivo release and metabolism of dopamine (DA) in mesolimbic and nigrostriatal DA neurons of the mouse was determined using gas chromatographic and mass fragmentographic (GC-MF) analysis. DA release was inferred from levels of 3-methoxytyramine (3-MT)...

journal_title：Journal of neurochemistry

authors： Boyar WC,Altar CA

更新日期：1987-03-01 00:00:00

abstract：:The characteristics of beta-alanine transport at the blood-brain barrier were studied by using primary cultured bovine brain capillary endothelial cells. Kinetic analysis of the beta-[3H]alanine transport indicated that the transporter for beta-alanine functions with Kt of 25.3 +/- 2.5 microM and Jmax of 6.90 +/- 0.48...

journal_title：Journal of neurochemistry

authors： Komura J,Tamai I,Senmaru M,Terasaki T,Sai Y,Tsuji A

更新日期：1996-07-01 00:00:00

abstract：:Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver, spleen, motor control, and brain; premature death invariably results. Its molecular origins were traced, as late as 1997, to a protein o...

journal_title：Journal of neurochemistry

authors： Wheeler S,Sillence DJ

更新日期：2020-06-01 00:00:00

abstract：:An alteration in signal transduction systems in Alzheimer's disease (AD) would likely be of pathophysiological significance, because these processes control normal brain functions. Previously, a diminished beta-adrenergic-mediated cyclic AMP response was found in cultured fibroblasts from AD patients. Because cross-ta...

journal_title：Journal of neurochemistry

authors： Huang HM,Lin TA,Sun GY,Gibson GE

更新日期：1995-02-01 00:00:00

abstract：:A vesicular glutamate transporter (VGLUT) is responsible for the accumulation of l-glutamate in synaptic vesicles in glutamatergic neurons. Two isoforms, VGLUT1 and VGLUT2, have been identified, which are complementarily expressed in these neurons. Mammalian pinealocytes, endocrine cells for melatonin, are also glutam...

journal_title：Journal of neurochemistry

authors： Morimoto R,Hayashi M,Yatsushiro S,Otsuka M,Yamamoto A,Moriyama Y

更新日期：2003-01-01 00:00:00

abstract：:We previously showed that Nuclear Factor kappaB (NF-kappaB) inactivation in astrocytes leads to improved functional recovery following spinal cord injury (SCI). This correlated with reduced expression of pro-inflammatory mediators and chondroitin sulfate proteoglycans, and increased white matter preservation. Hence we...

journal_title：Journal of neurochemistry

authors： Brambilla R,Hurtado A,Persaud T,Esham K,Pearse DD,Oudega M,Bethea JR

更新日期：2009-07-01 00:00:00

abstract：:The group I metabotropic glutamate receptor agonist (S)-3,5-dihydroxyphenylglycine (DHPG) elicited two phases of synchronized neuronal (epileptiform) discharges in hippocampal slices: an initial phase of short duration discharges followed by a phase of prolonged discharges. We assessed the involvement of transient rec...

journal_title：Journal of neurochemistry

authors： Wang M,Bianchi R,Chuang SC,Zhao W,Wong RK

更新日期：2007-04-01 00:00:00

abstract：:Cationic amino acids are transported from blood into brain by a saturable carrier at the blood-brain barrier (BBB). The transport properties of this carrier were examined in the rat using an in situ brain perfusion technique. Influx into brain via this system was found to be sodium independent and followed Michaelis-M...

journal_title：Journal of neurochemistry

authors： Stoll J,Wadhwani KC,Smith QR

更新日期：1993-05-01 00:00:00

abstract：:The neuronal nitric oxide (NO) synthase generates NO from arginine. NO mediates its physiological effects mainly by stimulating the synthesis of cyclic GMP. We have investigated the role of the arginine availability on the NMDA-induced cyclic GMP accumulation in immature rat brain slices. The effect of NMDA was blocke...

journal_title：Journal of neurochemistry

authors： Grima G,Cuénod M,Pfeiffer S,Mayer B,Do KQ

更新日期：1998-11-01 00:00:00

abstract：:Dopamine (DA)-producing neurons in the ventral midbrain are generated from a specified neuronal lineage and form selective axonal pathways that mediate multiple CNS functions. Expression of the gene encoding tyrosine hydroxylase (TH), which is a key enzyme of catecholamine biosynthesis, is regulated during the develop...

journal_title：Journal of neurochemistry

authors： Matsushita N,Okada H,Yasoshima Y,Takahashi K,Kiuchi K,Kobayashi K

更新日期：2002-07-01 00:00:00

abstract：:The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine D1 and D2 receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2-3 weeks after the insult. We observed significant decreases in the Bmax and KD for [3H]SCH 23390-labeled D1 and in the B...

journal_title：Journal of neurochemistry

authors： Przedborski S,Kostic V,Jackson-Lewis V,Cadet JL,Burke RE

更新日期：1991-12-01 00:00:00

abstract：:Platelet-activating factor (PAF) may be a neuromodulator involved in neural cell differentiation, cerebral inflammation, and ischemia. The PAF receptor is a member of the G protein-coupled receptor superfamily. In the present study, we sought to define the specific G protein(s) that mediate PAF-stimulated phosphoinosi...

journal_title：Journal of neurochemistry

authors： Shi LC,Wang HY,Horwitz J,Friedman E

更新日期：1996-10-01 00:00:00

abstract：:Prostaglandin E1 (PGE1)-mediated transmembrane signal control systems were investigated in intact murine neuroblastoma cells (clone N1E-115). PGE1 increased intracellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i). PGE1 transiently increased inositol 1,4,5-trisphosphate for...

journal_title：Journal of neurochemistry

authors： Kanba S,Sasakawa N,Nakaki T,Kanba KS,Yagi G,Kato R,Richelson E

更新日期：1991-12-01 00:00:00

abstract：:The effect of L-phenylalanine on the transport of tyrosine was studied using membrane vesicles from rat brain synaptosomes. Phenylalanine, which is accumulated in phenylketonuria, competitively inhibits tyrosine uptake at concentrations similar to those found in phenylketonuric patients, with a Ki of the same order of...

journal_title：Journal of neurochemistry

authors： Aragón MC,Giménez C,Valdivieso F

更新日期：1982-10-01 00:00:00

abstract：:We have characterised the induction of the mitogen-inducible form of cyclooxygenase, COX-2, in the rat cerebral cortex in response to excitotoxin injection into the nucleus basalis. This model is associated with intense stimulation of the ascending pathway to the cerebral cortex, seizure activity, and subsequent ipsil...

journal_title：Journal of neurochemistry

authors： Adams J,Collaço-Moraes Y,de Belleroche J

更新日期：1996-01-01 00:00:00

abstract：:The presence of a [3H]muscimol binding site on the purified benzodiazepine receptor was demonstrated. The purified protein was apparently homogeneous as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (stained with silver), with a molecular weight of 60,000 +/- 3000. The benzodiazepine binding sites...

journal_title：Journal of neurochemistry

authors： Martini C,Rigacci T,Lucacchini A

更新日期：1983-10-01 00:00:00

abstract：:In multiple sclerosis (MS), oligodendrocytes in lesions are lost, leaving damaged tissue virtually devoid of these myelin-producing cells. Our group has recently demonstrated enhanced expression of insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) in oligodendrocytes (CNPase(+)) localized adjacent to MS les...

journal_title：Journal of neurochemistry

authors： Chesik D,De Keyser J,Bron R,Fuhler GM

更新日期：2010-06-01 00:00:00

abstract：:Proteins that control the excitability of neurons, including voltage-dependent ion channels and neurotransmitter receptors, reside in a membrane lipid environment that includes sphingomyelin, but the influence of the metabolism of this lipid on excitability is unknown. Sphingomyelin in the plasma membrane can be cleav...

journal_title：Journal of neurochemistry

authors： Norman E,Cutler RG,Flannery R,Wang Y,Mattson MP

更新日期：2010-07-01 00:00:00