Inhibition by L-phenylalanine of tyrosine transport by synaptosomal plasma membrane vesicles: implications in the pathogenesis of phenylketonuria.

Abstract:

:The effect of L-phenylalanine on the transport of tyrosine was studied using membrane vesicles from rat brain synaptosomes. Phenylalanine, which is accumulated in phenylketonuria, competitively inhibits tyrosine uptake at concentrations similar to those found in phenylketonuric patients, with a Ki of the same order of the Km for tyrosine. This inhibition could be responsible for the depletion of catecholamines observed in phenylketonuria.

journal_name

J Neurochem

authors

Aragón MC,Giménez C,Valdivieso F

doi

10.1111/j.1471-4159.1982.tb11513.x

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

1185-7

issue

4

eissn

0022-3042

issn

1471-4159

journal_volume

39

pub_type

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