Abstract:
OBJECTIVES:To assess whether radiomics signature can identify aggressive behavior and predict recurrence of hepatocellular carcinoma (HCC) after liver transplantation. METHODS:Our study consisted of a training dataset (n = 93) and a validation dataset (40) with clinically confirmed HCC after liver transplantation from October 2011 to December 2016. Radiomics features were extracted by delineating regions-of-interest (ROIs) around the lesion in four phases of CT images. A radiomics signature was generated using the least absolute shrinkage and selection operator (LASSO) Cox regression model. The association between radiomics signature and recurrence-free survival (RFS) was assessed. Preoperative clinical characteristics potentially associated with RFS were evaluated to develop a clinical model. A combined model incorporating clinical risk factors and radiomics signature was built. RESULTS:The stable radiomics features associated with the recurrence of HCC were simply found in arterial phase and portal phase. The prediction model based on the radiomics features extracted from the arterial phase showed better prediction performance than the portal vein phase or the fusion signature combining both of arterial and portal vein phase. A radiomics nomogram based on combined model consisting of the radiomics signature and clinical risk factors showed good predictive performance for RFS with a C-index of 0.785 (95% confidence interval [CI]: 0.674-0.895) in the training dataset and 0.789 (95% CI: 0.620-0.957) in the validation dataset. The calibration curves showed agreement in both training (p = 0.121) and validation cohorts (p = 0.164). CONCLUSIONS:Radiomics signature extracted from CT images may be a potential imaging biomarker for liver cancer invasion and enable accurate prediction of HCC recurrence after liver transplantation.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Guo D,Gu D,Wang H,Wei J,Wang Z,Hao X,Ji Q,Cao S,Song Z,Jiang J,Shen Z,Tian J,Zheng Hdoi
10.1016/j.ejrad.2019.05.010subject
Has Abstractpub_date
2019-08-01 00:00:00pages
33-40eissn
0720-048Xissn
1872-7727pii
S0720-048X(19)30179-2journal_volume
117pub_type
杂志文章abstract:PURPOSE:To define National Diagnostic Reference Levels (NDRLs) for computed tomography (CT) for Austria on adult patients. METHOD:In the course of a nationwide survey on common CT-examinations between June 2018 and November 2018, datasets were requested from all Austrian hospitals and radiology centers with CT-scanner...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108863
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:For a successful bronchoscopic lung volume reduction coil treatment it is important to place the coils in the most emphysematous lobes. Therefore assessment of the lobe with greatest destruction is essential. Our aims were to investigate the level of agreement among expert reviewers of HRCT-scans in emphysema p...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2021.109561
更新日期:2021-01-23 00:00:00
abstract:PURPOSE:To evaluate the value of a vessel removal algorithm in segmentation of subsolid nodules by comparing the software solid component measurement on CT, before and after vessel removal, with the measurement of the invasive component on pathology in lung adenocarcinomas manifesting as subsolid nodules. MATERIALS AN...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.01.016
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate two different iodine concentrations of contrast material for detecting hypervascular hepatocellular carcinomas (HCCs) in cirrhotic liver by multi-detector row helical CT (MDCT) when a fixed contrast material volume and injection rate is used. MATERIALS AND METHODS:Institutional Review Board approva...
journal_title:European journal of radiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejrad.2010.10.006
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the variations in Doppler waveforms and flow velocity during respiratory manoeuvres in healthy individuals with no liver disease. MATERIALS AND METHODS:In total, 100 individuals (75 women and 25 men) without known cardiac or liver disease were examined prospectively with...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.01.011
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To investigate the diagnostic value of retrospective fusion of pelvic MRI and (18)F-fluorodeoxyglucose ((18)F-FDG) PET images for assessment of locoregional extension and nodal staging of endometrial cancer. MATERIALS AND METHODS:Thirty patients with biopsy-proven endometrial cancer underwent preoperative cont...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2013.05.005
更新日期:2013-10-01 00:00:00
abstract:INTRODUCTION:Parosteal osteosarcomas and well-differentiated liposarcomas (WDLPS) of soft tissue share several features: they are slowly progressive, locally aggressive tumors, tend to recur locally, and rarely or never metastasizes if not dedifferentiated. Their treatment is wide surgical resection. Microscopically, b...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.11.035
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. METHODS:HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(00)00236-9
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To verify the feasibility of synthetic MRI in quantitative evaluation of lumbar intervertebral disk (IVD) degeneration, as compared to the conventional CarrPurcell-Meiboom-Gill (CPMG) T2 mapping approach. METHODS:Twenty-four patients with chronic low back pain participated in this study. Patients underwent rou...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108858
更新日期:2020-03-01 00:00:00
abstract::Only few publication have so far been known on case histories in the context of CT-findings of hepatic adenoma (HA). An analysis was, therefore, made of the findings of ten patients with HA. Precontrast and postcontrast scans (dynamic CT), densitometric evaluations (gamma-fit) and "profile" determination were taken in...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:PURPOSE:To evaluate the image quality of early postoperative CT angiography with low contrast material and radiation dose using model-based iterative reconstruction (FIRST) for screening pseudoaneurysms after partial nephrectomy. METHODS:CT angiography was obtained before surgery using conventional iterative dose redu...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108853
更新日期:2020-03-01 00:00:00
abstract::The aim of this paper is to describe the modern imaging methods, their techniques, ability, and performance in staging head and neck lymph nodes. Also, the imaging morphologies of benign and malignant lymph nodes according to the different imaging techniques will be delineated. The imaging techniques of ultrasound inc...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2005.12.040
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine transit times for excretion of Gd-EOB-DTPA into different segments of the hepatobiliary system in patients with normal liver function. METHODS:This retrospective study was IRB approved with a waiver of consent granted. 61 patients (39 female, 22 male, mean age 52.5 ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.03.008
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Usefulness of biexponentially fitted signal attenuation at different b-values for differentiating the histological characteristics of renal tumors. MATERIALS AND METHODS:A total of 26 patients with 28 renal masses (histologically proven: 20 clear cell renal cell carcinomas [ccRCC], three transitional cell carc...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.10.016
更新日期:2012-03-01 00:00:00
abstract:AIM:The aim of this study was to compare the diagnostic accuracy of fully diagnostic, contrast-enhanced whole-body FDG-PET/CT and whole-body MRI for detection of bone metastases in patients suffering from newly diagnosed non-small cell lung cancer and malignant melanoma. MATERIAL AND METHODS:109 consecutive non-small ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.10.031
更新日期:2011-06-01 00:00:00
abstract::Skeletal traumas are among the most common routine challenges faced by Emergency Radiologists, in particular in case of radiographically occult nondisplaced fractures or in case of soft tissue injuries. With the development of Dual Energy Computed Tomography (DECT) technology, new post-processing applications have gai...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109456
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:To investigate the diagnostic value of shear wave elastography (SWE) in identifying cervical small lymph node metastases in nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS:This prospective study was approved by the local institutional review board. From July 2014 to March 2016, 114 sLNs from ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.03.006
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To compare accuracy of non-enhanced CT (NECT) (no oral or IV contrast) and enhanced CT (ECT) (IV enhanced only) to diagnose small bowel obstruction and evaluate reviewer's experience impact. MATERIALS AND METHODS:Ninety-nine adult patients underwent 105 NECT and ECT (6 patients had 2 examinations) on a four-de...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2008.04.011
更新日期:2009-07-01 00:00:00
abstract::A case is reported in which the typical radiographic appearances of acute emphysematous cholecystitis were due to acute gall bladder infarction following thrombotic occlusion of the superior mesenteric artery. ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Nowadays, endoscopic management of ureteropelvic junction (UPJ) obstruction is the treatment of choice. However, in the presence of crossing vessels, the success rate of endoscopic management decreases and the risk of hemorrhagic and vascular complications rises. The purpose of this study is to evaluate pati...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2006.08.027
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:This study assesses the diagnostic utility of olfactory nerve and bulb morphologies in addition to volumetric analysis in classification of different olfactory dysfunction etiologies. METHODS:106 patients presenting with olfactory loss and 17 control subjects were included. Based on detailed anamnesis, smell t...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109290
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Major arterial hemorrhage is an uncommon but serious complication of pancreatitis with high morbidity and mortality. Digital subtraction angiography (DSA) has long been the gold standard for the detection of a visceral artery pseudoaneurysm or for the site of active bleeding in patients with pancreatitis. Multi...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2006.02.006
更新日期:2006-08-01 00:00:00
abstract::Statins are widely used to lower increased cholesterol levels with the aim to prevent major cardiovascular events. However, they bare the risk of myotoxic side effects. We report on two patients with focal weakness and pain in the upper extremities. In both patients, abnormal MRI signal heights in the muscle groups in...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.12.031
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To assess the effect of parenteral butylscopolamine on magnetic resonance cholangiopancreatography (MRCP) image quality. MATERIALS AND METHODS:The 3D free-breathing respiratory-compensated MRCP images (mean acquisition time 7min) of 94 consecutive non-paired patients (47 with and 47 without 20mg intramuscular ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2012.11.023
更新日期:2013-04-01 00:00:00
abstract::Tendon imaging is mainly performed with ultrasonography (US) and magnetic resonance imaging (MRI) and has been improved within the last years because of technical advancements and a better understanding of tendon pathology. Several concepts concerning the etiology and the course of tendon diseases have influenced imag...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/s0720-048x(97)00058-2
更新日期:1997-11-01 00:00:00
abstract:PURPOSE:To evaluate the early enhancement of coronary atherosclerotic plaque using contrast-enhanced MR angiography (CE-MRA) and investigate the association between unstable angina pectoris (UAP) and early enhancement of the plaque. METHODS:Forty-one patients presenting with angina pectoris and demonstrating single-ve...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.07.020
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of sonography-guided percutaneous microwave ablation of intrahepatic primary cholangiocarcinoma. MATERIALS AND METHODS:From May 2006 to March 2010, 15 patients (11 men, 4 women; mean age, 57.4 years) with 24 histologically proven intrahepatic primary cholangiocarcinoma les...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.01.014
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect of transarterial pulsed perfusion with 60 °C saline on vascular permeability of tumor tissue, as well as its hepatic and renal toxicity, in a rabbit VX2 liver model. MATERIALS AND METHODS:VX2 carcinomas were grown in rabbit livers, forty male New Zealand white tumor-bearing rabbits were ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.01.108
更新日期:2012-03-01 00:00:00
abstract::NMR examinations were performed on a total of 109 patients using a resistive magnet. In 67 patients various organs and tissues of the face and neck the trunk and the limbs were evaluated in axial, sagittal and coronal planes. The use of more than one sequence time is essential for adequate representation of the anatom...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract:PURPOSE:To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. MATERIALS AND METHODS:Forty-two HCM patients, including 25 HCM ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.01.008
更新日期:2014-04-01 00:00:00