Abstract:
:A 26-year-old woman committed suicide by ingestion of a large quantity of tocainide, a recently developed oral antiarrhythmic agent with chemical similarities to lidocaine. Blood and bodily fluid analysis by thin-layer chromatography, high pressure liquid chromatography, and mass spectroscopy confirmed the presence of tocainide, with a serum level of 68 mg/L, nearly 7 times the upper recommended therapeutic level for this drug. Tocainide was also detected at significant levels in vitreous fluid and bile. Although the mechanism of death from tocainide intoxication in animal studies is related to central nervous system toxicity, the presentation of ventricular tachyarrhythmias with coma in this patient suggests that tocainide at high levels may have primary myocardiotoxicity in humans.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Sperry K,Wohlenberg N,Standefer JCsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
1440-6issue
5eissn
0022-1198issn
1556-4029journal_volume
32pub_type
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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doi:
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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journal_title:Journal of forensic sciences
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更新日期:1998-09-01 00:00:00
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journal_title:Journal of forensic sciences
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Journal of forensic sciences
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更新日期:2003-05-01 00:00:00
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journal_title:Journal of forensic sciences
pub_type: 杂志文章
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更新日期:1979-04-01 00:00:00
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