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MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma.

Abstract：

:Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and it can be locally invasive and metastatic to distant sites. MicroRNAs (miRNAs or miRs) are endogenous, small, non-coding RNAs of 19-25 nucleotides in length, that are involved in regulating gene expression at a post-transcriptional level. MicroRNAs have been implicated in diverse biological functions and diseases. In cancer, miRNAs can proceed either as oncogenic miRNAs (onco-miRs) or as tumor suppressor miRNAs (oncosuppressor-miRs), depending on the pathway in which they are involved. Dysregulation of miRNA expression has been shown in most of the tumors evaluated. MiRNA dysregulation is known to be involved in the development of cutaneous squamous cell carcinoma (CSCC). In this review, we focus on the recent evidence about the role of miRNAs in the development of CSCC and in the prognosis of this form of skin cancer.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

García-Sancha N,Corchado-Cobos R,Pérez-Losada J,Cañueto J

doi

10.3390/ijms20092181

subject

Has Abstract

pub_date

2019-05-02 00:00:00

issue

9

issn

1422-0067

pii

ijms20092181

journal_volume

20

pub_type

杂志文章,评审

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