Robust and accurate quantification of biomarkers of immune cells in lung cancer micro-environment using deep convolutional neural networks.

abstract：:The genus Nothofagus is the main component of southern South American temperate forests. The 40 Nothofagus species, evergreen and deciduous, and some natural hybrids are spread among Central and Southern Chile, Argentina, New Zealand, Australia, New Guinea and New Caledonia. Nothofagus nervosa, Nothofagus obliqua and ...

journal_title：PeerJ

authors： Solano J,Anabalón L,Encina F,Esse C,Penneckamp D

更新日期：2019-05-09 00:00:00

abstract：:Ethylene response factors (ERFs) are plant-specific transcription factors (TFs) that play important roles in plant growth and stress defense and have received a great amount of attention in recent years. In this study, seven ERF genes related to abiotic stress tolerance and response were identified in plants of the Po...

journal_title：PeerJ

authors： Huang J,Wang S,Wang X,Fan Y,Han Y

更新日期：2020-10-20 00:00:00

abstract：:Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam. A torque meter measures the turning attempts of the tethered fly around its vertical body axis. By punishing, say, left turning attempts (in a homogeneous env...

journal_title：PeerJ

authors： Colomb J,Brembs B

更新日期：2016-04-25 00:00:00

abstract：:There is growing concern that some bee populations are in decline, potentially threatening pollination security in agricultural and non-agricultural landscapes. Among the numerous causes associated with this trend, nutritional stress resulting from a mismatch between bee nutritional needs and plant community provision...

journal_title：PeerJ

authors： Pamminger T,Becker R,Himmelreich S,Schneider CW,Bergtold M

更新日期：2019-02-27 00:00:00

abstract：:The stings of bees, wasps, and ants are something that catches the attention of anyone that experiences them. While many recent studies have focused on the pain inflicted by the stings of various stinging wasps, bees, or ants (Hymenoptera: Aculeata), little is known about how the length of the sting itself varies betw...

journal_title：PeerJ

authors： Sadler EA,Pitts JP,Wilson JS

更新日期：2018-05-02 00:00:00

abstract：:Diffuse sources of pollution like agricultural or urban runoff are important factors in determining the quality of surface waters, although they are more difficult to monitor than point sources. The objective of our study was to verify assumptions that the inflow from agricultural nutrient sources is higher than from ...

journal_title：PeerJ

authors： Matej-Lukowicz K,Wojciechowska E,Nawrot N,Dzierzbicka-Głowacka LA

更新日期：2020-02-06 00:00:00

abstract：BACKGROUND:Parasites are essential components of natural communities, but the factors that generate skewed distributions of parasite occurrences and abundances across host populations are not well understood. METHODS:Here, we analyse at a seascape scale the spatiotemporal relationships of parasite exposure and host bo...

journal_title：PeerJ

authors： Rodríguez SM,Valdivia N

更新日期：2017-08-17 00:00:00

abstract：:Metoposaurids are representatives of the extinct amphibian clade Temnospondyli, found on almost every continent exclusively in the Late Triassic deposits. Osteohistologically, it is one of the best-known temnospondyl groups, analyzed with a wide spectrum of methods, such as morphology, morphometry, bone histology or c...

journal_title：PeerJ

authors： Teschner EM,Chakravorti S,Sengupta DP,Konietzko-Meier D

更新日期：2020-09-08 00:00:00

abstract：:Although liver cirrhosis and hepatocellular carcinoma are major consequences of hepatitis C (HCV), there has been an increasing number of studies examining extrahepatic manifestations, especially those caused by systemic chronic inflammation and metabolic complications that might predispose HCV patients to atheroscler...

journal_title：PeerJ

authors： Pavicic Ivelja M,Dolic K,Tandara L,Perkovic N,Mestrovic A,Ivic I

更新日期：2021-01-14 00:00:00

abstract：:Circadian rhythms maintain a 24 h oscillation pattern in metabolic, physiological and behavioral processes in all living organisms. Circadian rhythms are organized as biochemical networks located in hypothalamus and peripheral tissues. Rhythmicity in the expression of circadian clock genes plays a vital role in regula...

journal_title：PeerJ

authors： Hassan A,Ahmad J,Ashraf H,Ali A

更新日期：2018-06-06 00:00:00

abstract：:The spatial-temporal evolution of land use and land cover (LULC) and its multi-scale impact on the water environment is becoming highly significant in the LULC research field. The current research results show that the more significant scale impact on LULC and water quality in the whole basin and the riparian buffer s...

journal_title：PeerJ

authors： Li S,Peng S,Jin B,Zhou J,Li Y

更新日期：2019-07-15 00:00:00

abstract：:The incidence of pediatric cancer is lower than that of adult cancer worldwide. However, the former has detrimental side effects on the health of individuals, even after the cancer is cured, due to the impact of treatment on development. Recently, correlations have been made between the gut microbiome and cancer in se...

journal_title：PeerJ

authors： Sahly N,Moustafa A,Zaghloul M,Salem TZ

更新日期：2019-09-23 00:00:00

abstract：:Cold-water corals provide an important habitat for a rich fauna along the continental margins and slopes. Although these azooxanthellate corals are considered particularly sensitive to ocean acidification, their responses to natural variations in pH and aragonite saturation are largely unknown due to the difficulty of...

journal_title：PeerJ

authors： Fillinger L,Richter C

更新日期：2013-10-29 00:00:00

abstract：:Rearing coral fragments in nurseries and subsequent transplantation onto a degraded reef is a common approach for coral reef restoration. However, if barnacles and other biofouling organisms are not removed prior to transplantation, fish will dislodge newly cemented corals when feeding on biofouling organisms. This be...

journal_title：PeerJ

authors： Frias-Torres S,van de Geer C

更新日期：2015-09-29 00:00:00

abstract：:Mesacanthus is a common and speciose genus of acanthodian fish from Lower Old Red Sandstone and Middle Old Red Sandstone assemblages (representing the Lower Devonian and Middle Devonian respectively) and is well represented in many palaeoichthyology collections in the UK. Based upon descriptions given during the 19th ...

journal_title：PeerJ

authors： Baron MG

更新日期：2015-10-29 00:00:00

abstract：:Rhizoctonia solani causes the disease peanut sheath blight, involving symptoms of maceration and necrosis of infected tissue, mainly caused by cell-wall-degrading enzymes (CWDEs). This study investigated the production of CWDEs including polygalacturonase (PG), polymethyl-galacturonase (PMG), cellulase (Cx) and β-gluc...

journal_title：PeerJ

authors： Xue CY,Zhou RJ,Li YJ,Xiao D,Fu JF

更新日期：2018-09-05 00:00:00

abstract：:Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed to one round of phototoxic treatment with adult zebr...

journal_title：PeerJ

authors： Ranski AH,Kramer AC,Morgan GW,Perez JL,Thummel R

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4 knockout (KO) mouse h...

journal_title：PeerJ

authors： Wang M,Huang YP,Wu H,Song K,Wan C,Chi AN,Xiao YM,Zhao XY

更新日期：2017-05-18 00:00:00

abstract：:Phlorotannins are primary and/or secondary metabolites found exclusively in brown seaweeds, but their geographic distribution and abundance dynamic are not very well understood. In this study we evaluated the phlorotannin concentrations among and within-species of brown seaweeds in a broad latitudinal context (range o...

journal_title：PeerJ

authors： Ank G,da Gama BAP,Pereira RC

更新日期：2019-08-14 00:00:00

abstract：:In most electric fish species, the electric organ (EO) derives from striated muscle cells that suppress many muscle properties. In the gymnotiform Sternopygus macrurus, mature electrocytes, the current-producing cells of the EO, do not contain sarcomeres, yet they continue to make some cytoskeletal and sarcomeric prot...

journal_title：PeerJ

authors： Pinch M,Güth R,Samanta MP,Chaidez A,Unguez GA

更新日期：2016-04-14 00:00:00

abstract：Background:Sex ratio distorting agents (maternally inherited symbionts and meiotically-driving sex chromosomes) are common in insects. When these agents rise to high frequencies they create strong population sex ratio bias and selection then favours mutations that act to restore the rare sex. Despite this strong select...

journal_title：PeerJ

authors： Reynolds LA,Hornett EA,Jiggins CD,Hurst GDD

更新日期：2019-10-01 00:00:00

abstract：:Helminths include both parasitic nematodes (roundworms) and platyhelminths (trematode and cestode flatworms) that are abundant, and are of clinical importance. The genetic characterization of parasitic flatworms using advanced molecular tools is central to the diagnosis and control of infections. Although the nuclear ...

journal_title：PeerJ

authors： Biswal DK,Ghatani S,Shylla JA,Sahu R,Mullapudi N,Bhattacharya A,Tandon V

更新日期：2013-11-12 00:00:00

abstract：:Ocean acidification (OA) is one of the most significant threats to marine life, and is predicted to drive important changes in marine communities. Although OA impacts will be the sum of direct effects mediated by alterations of physiological rates and indirect effects mediated by shifts in species interactions and bio...

journal_title：PeerJ

authors： Lim EG,Harley CDG

更新日期：2018-07-31 00:00:00

abstract：:Accurate identification of protein-protein interactions (PPI) is the key step in understanding proteins' biological functions, which are typically context-dependent. Many existing PPI predictors rely on aggregated features from protein sequences, however only a few methods exploit local information about specific resi...

journal_title：PeerJ

authors： Zubek J,Tatjewski M,Boniecki A,Mnich M,Basu S,Plewczynski D

更新日期：2015-07-02 00:00:00

abstract：:The Natural Mortality coefficient (M) is a key parameter for stock assessments. The need to establish age-specific natural mortality coefficients is widely recognized because M decreases rapidly over the early stages of the life cycle until it reaches a stable M value around the age-at-maturity. The aim of this study ...

journal_title：PeerJ

authors： Romero-Gallardo S,Velázquez-Abunader I,López-Rocha JA,Garza-Gisholt E

更新日期：2018-07-18 00:00:00

abstract：Background:Health education can benefit people with chronic diseases. However, in previous research those benefits were small, and reinforcement to maintain them was not effective. A possible explanation is that the benefits appeared to be small and reinforcement appeared to be ineffective because those analyses mixed ...

journal_title：PeerJ

authors： Park MJ,Green J,Jung HS,Park YS

更新日期：2019-07-15 00:00:00

abstract：INTRODUCTION:Theory predicts that habitat fragmentation, by reducing population size and increasing isolation among remnant populations, can alter their genetic diversity and structure. A cascade of effects is expected: genetic drift and inbreeding after a population bottleneck, changes in biotic interactions that may ...

journal_title：PeerJ

authors： Suárez-Montes P,Chávez-Pesqueira M,Núñez-Farfán J

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:The human microbiota plays a key role in health and disease, and bacteriocins, which are small, bacterially produced, antimicrobial peptides, are likely to have an important function in the stability and dynamics of this community. Here we examined the density and distribution of the subclass I lantibiotic m...

journal_title：PeerJ

authors： Walsh CJ,Guinane CM,O' Toole PW,Cotter PD

更新日期：2017-04-27 00:00:00

abstract：:Recent field trips to Member III of the Naobaogou Formation, Nei Mongol, China yielded new fossil discoveries, increasing our knowledge of the late Permian continental fauna from China. We present here a new large therocephalian, Jiufengia jiai gen. et sp. nov., represented by a partial skull with mandibles and part o...

journal_title：PeerJ

authors： Liu J,Abdala F

更新日期：2019-02-22 00:00:00

abstract：:The ornamental trade is a worldwide industry worth >15 billion USD with a problem of rampant product misidentification. Minimizing misidentification is critical in the face of overexploitation of species in the trade. We surveyed the peppermint shrimp ornamental marketplace in the southeastern USA, the most intense ma...

journal_title：PeerJ

authors： Baeza JA,Behringer DC

更新日期：2017-09-18 00:00:00