Characterization of retinal regeneration in adult zebrafish following multiple rounds of phototoxic lesion.

Abstract:

:Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed to one round of phototoxic treatment with adult zebrafish exposed to six consecutive rounds of phototoxic treatment. We observed that Müller glia continued to re-enter the cell cycle to produce clusters of retinal progenitors in zebrafish exposed to multiple rounds of phototoxic light. Some abnormalities were noted, however. First, we found that retinas exposed to multiple rounds of damage exhibited a greater loss of photoreceptors at 36 hours of light damage than retinas that were exposed to their first round of light damage. In addition, we found that Müller glia appeared to have an increase in the acute gliotic response in retinas exposed to multiple rounds of light treatment. This was evidenced by cellular hypertrophy, changes in GFAP cellular localization, and transient increases in stat3 and gfap expression. Finally, following the sixth round of phototoxic lesion, we observed a significant increase in mis-localized HuC/D-positive amacrine and ganglion cells in the inner plexiform layer and outer retina, and a decreased number of regenerated blue cone photoreceptors. These data add to recent findings that retinal regeneration in adult zebrafish occurs concomitant with Müller glia reactivity and can result in the generation of aberrant neurons. These data are also the first to demonstrate that Müller glia appear to modify their phenotype in response to multiple rounds of phototoxic lesion, exhibiting an increase in acute gliosis while maintaining a remarkable capacity for long-term regeneration of photoreceptors.

journal_name

PeerJ

journal_title

PeerJ

authors

Ranski AH,Kramer AC,Morgan GW,Perez JL,Thummel R

doi

10.7717/peerj.5646

subject

Has Abstract

pub_date

2018-09-20 00:00:00

pages

e5646

issn

2167-8359

pii

5646

journal_volume

6

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Serum lipid level is not associated with symptomatic intracerebral hemorrhage after intravenous thrombolysis for acute ischemic stroke.

    abstract:Background:This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods:We retrospectively analyzed consecutive ischemic stroke patients who wer...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6021

    authors: Lin TC,Lin YK,Chen CI,Chan L,Chi NF,Yuan RY,Sheu JJ,Wei CR,Tsai JP,Yeh TH

    更新日期:2018-11-23 00:00:00

  • Age-related alterations in inhibitory control investigated using the minimally delayed oculomotor response task.

    abstract::Healthy, older adults are widely reported to experience cognitive decline, including impairments in inhibitory control. However, this general proposition has recently come under scrutiny because ageing effects are highly variable between individuals, are task dependent, and are sometimes not distinguished from general...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8401

    authors: Knox PC,Pasunuru N

    更新日期:2020-01-09 00:00:00

  • Trends and topics in eye disease research in PubMed from 2010 to 2014.

    abstract:BACKGROUND:The purpose of this study is to provide a report on scientific production during the period 2010-2014 in order to identify the major topics as well as the predominant actors (journals, countries, continents) involved in the field of eye disease. METHODS:A PubMed search was carried out to extract articles re...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1557

    authors: Boudry C,Denion E,Mortemousque B,Mouriaux F

    更新日期:2016-01-07 00:00:00

  • Pre- and post-experimental manipulation assessments confirm the increase in number of birds due to the addition of nest boxes.

    abstract::Secondary cavity nesting (SCN) birds breed in holes that they do not excavate themselves. This is possible where there are large trees whose size and age permit the digging of holes by primary excavators and only rarely happens in forest plantations, where we expected a deficit of both breeding holes and SCN species. ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1806

    authors: Cuatianquiz Lima C,Macías Garcia C

    更新日期:2016-03-15 00:00:00

  • The advanced lung cancer inflammation index predicts short and long-term outcomes in patients with colorectal cancer following surgical resection: a retrospective study.

    abstract:Background and Purpose:Several studies have proposed that the advanced lung cancer inflammation index (ALI), a new inflammation-related index, can be used for the prognosis assessment of various malignancies. However, few studies have reported its prognostic value in colorectal cancer (CRC). Therefore, this study explo...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10100

    authors: Xie H,Huang S,Yuan G,Kuang J,Yan L,Wei L,Tang S,Gan J

    更新日期:2020-10-08 00:00:00

  • The effect of voluntary head movements on postural kinetics in the standing cat.

    abstract:Background:Although the postural instability accompanying bilateral vestibular loss in human and quadrupeds during lateral head movements are well-known, it is still unclear whether or not lateral head turns would indeed activate the postural control system to maintain balance. This study aimed to examine the kinetic p...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8186

    authors: Song Y,Wang M,Baker JS,Gu Y

    更新日期:2019-12-12 00:00:00

  • Nutritional assessment, phytochemical composition and antioxidant analysis of the pulp and seed of medjool date grown in Mexico.

    abstract::The aim of this study was the characterization of fatty acids, antioxidant activity, some physical properties, nutrient content, sugars, and minerals in the pulp and seeds of the date cultivar 'Medjool' (Phoenix dactylifera L.) grown in Mexico. The samples were obtained at maturity (Tamar) in the 2017 harvest season i...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6821

    authors: Salomón-Torres R,Ortiz-Uribe N,Valdez-Salas B,Rosas-González N,García-González C,Chávez D,Córdova-Guerrero I,Díaz-Rubio L,Haro-Vázquez MDP,Mijangos-Montiel JL,Morales-Maza A,Mahadevan P,Krueger R

    更新日期:2019-07-17 00:00:00

  • Hydrology controls recruitment of two invasive cyprinids: bigheaded carp reproduction in a navigable large river.

    abstract::In the Mississippi River Basin of North America, invasive bigheaded carp (silver carp Hypophthalmichthys molitrix and bighead carp H. nobilis, also referred to as Asian carp) have spread rapidly over the past several decades. In the Illinois River, an important tributary of the Upper Mississippi River, reproduction ap...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3641

    authors: Gibson-Reinemer DK,Solomon LE,Pendleton RM,Chick JH,Casper AF

    更新日期:2017-09-14 00:00:00

  • Rapid rise in toxic load for bees revealed by analysis of pesticide use in Great Britain.

    abstract::A strong argument can be made that the European Union has the most rigorous regulatory system for pesticides in the world, and that modern pesticide use poses fewer environmental threats than older regimes. Nevertheless, the impacts of pesticides on bees and other non-target organisms are much debated in Europe as els...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5255

    authors: Goulson D,Thompson J,Croombs A

    更新日期:2018-07-19 00:00:00

  • A relationship between species richness and evenness that depends on specific relative abundance distribution.

    abstract::Although many ecologists focus on the relationship between species richness (S) and evenness (E), conflicts between observation and theory are difficult to reconcile. Empirical S-E relationships were not consistent, while relationships show strong correlation between S and E. Since E essentially depended on the relati...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4951

    authors: Su Q

    更新日期:2018-06-12 00:00:00

  • Characteristics and outcomes of hemodialysis patients with COVID-19: a retrospective single center study.

    abstract:Background:The coronavirus 19 (COVID-19) pandemic has heightened the threat to the health and lives of patients with comorbid diseases. Infection by COVID-19 is especially detrimental to patients on hemodialysis. In this study, we evaluated the clinical characteristics, laboratory findings, treatments and prognoses of ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10459

    authors: Luo Y,Li J,Liu Z,Yu H,Peng X,Cao C

    更新日期:2020-11-26 00:00:00

  • Ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parrotfish Scarus zelindae.

    abstract::Parrotfish are fundamental species in controlling algal phase-shifts and ensuring the resilience of coral reefs. Nevertheless, little is known on their ecological role in the south-western Atlantic Ocean. The present study analysed the ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parr...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2536

    authors: Pereira PH,Santos M,Lippi DL,Silva P

    更新日期:2016-10-12 00:00:00

  • DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma.

    abstract:Background:Except for a few studies with contradictory observations, information is lacking on the possibility of association between DNA mismatch repair (MMR) status and the presence of cancer stem cells in colorectal carcinoma (CRC), two important aspects in colorectal carcinogenesis. Methods:Eighty (40 right-sided ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5530

    authors: Cheah PL,Li J,Looi LM,Teoh KH,Ong DB,Arends MJ

    更新日期:2018-09-11 00:00:00

  • An updated assessment of Symbiodinium spp. that associate with common scleractinian corals from Moorea (French Polynesia) reveals high diversity among background symbionts and a novel finding of clade B.

    abstract::The adaptative bleaching hypothesis (ABH) states that, depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to "switch" or "shuffle" their algal symbionts), coral bleaching can lead to a change in the composition of their associated Symbiodinium community and, thus, contribute to the cora...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2856

    authors: Rouzé H,Lecellier GJ,Saulnier D,Planes S,Gueguen Y,Wirshing HH,Berteaux-Lecellier V

    更新日期:2017-01-05 00:00:00

  • Predicting the effect of variants on splicing using Convolutional Neural Networks.

    abstract::Mutations that cause an error in the splicing of a messenger RNA (mRNA) can lead to diseases in humans. Various computational models have been developed to recognize the sequence pattern of the splice sites. In recent studies, Convolutional Neural Network (CNN) architectures were shown to outperform other existing mod...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9470

    authors: Thanapattheerakul T,Engchuan W,Chan JH

    更新日期:2020-07-06 00:00:00

  • Multimode ultrasonic technique is recommended for the differential diagnosis of thyroid cancer.

    abstract:Background:B-mode ultrasound is one of the most commonly used imaging techniques for evaluating thyroid nodules due to its noninvasive property and excellent performance in terms of discriminating between benign and malignant nodules. However, the accuracy of differential diagnosis strongly depends on the experience of...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9112

    authors: Wang J,He X,Ma L,Li M,Sun L,Jiang J,Zhou Q

    更新日期:2020-05-04 00:00:00

  • Morphological traits: predictable responses to macrohabitats across a 300 km scale.

    abstract::Species traits may provide a short-cut to predicting generalities in species turnover in response to environmental change, particularly for poorly known taxa. We ask if morphological traits of assemblages respond predictably to macrohabitats across a large scale. Ant assemblages were collected at nine paired pasture a...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.271

    authors: Yates ML,Andrew NR,Binns M,Gibb H

    更新日期:2014-03-04 00:00:00

  • Deep-sea water displacement from a turbidity current induced by the Super Typhoon Hagibis.

    abstract::Turbidity currents are the main drivers behind the transportation of terrestrial sediments to the deep sea, and turbidite deposits from such currents have been widely used in geological studies. Nevertheless, the contribution of turbidity currents to vertical displacement of seawater has rarely been discussed. This is...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10429

    authors: Kawagucci S,Miwa T,Lindsay DJ,Ogura E,Yamamoto H,Nishibayashi K,Yokooka H,Nishi S,Takahashi A,Lee S

    更新日期:2020-12-09 00:00:00

  • Under-five mortality among mothers employed in agriculture: findings from a nationally representative sample.

    abstract::Background. India accounts for 24% to all under-five mortality in the world. Residence in rural area, poverty and low levels of mother's education are known confounders of under-five mortality. Since two-thirds of India's population lives in rural areas, mothers employed in agriculture present a particularly vulnerabl...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.710

    authors: Singh R,Tripathi V

    更新日期:2015-01-08 00:00:00

  • Whole gut microbiome composition of damselfish and cardinalfish before and after reef settlement.

    abstract::The Pomacentridae (damselfish) and Apogonidae (cardinalfish) are among the most common fish families on coral reefs and in the aquarium trade. Members of both families undergo a pelagic larvae phase prior to settlement on the reef, where adults play key roles in benthic habitat structuring and trophic interactions. Fi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2412

    authors: Parris DJ,Brooker RM,Morgan MA,Dixson DL,Stewart FJ

    更新日期:2016-08-31 00:00:00

  • Population genetic structure of Patagonian toothfish (Dissostichus eleginoides) in the Southeast Pacific and Southwest Atlantic Ocean.

    abstract::Previous studies of population genetic structure in Dissostichus eleginoides have shown that oceanographic and geographic discontinuities drive in this species population differentiation. Studies have focused on the genetics of D. eleginoides in the Southern Ocean; however, there is little knowledge of their genetic v...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4173

    authors: Canales-Aguirre CB,Ferrada-Fuentes S,Galleguillos R,Oyarzun FX,Hernández CE

    更新日期:2018-01-16 00:00:00

  • Predicting disease occurrence of cabbage Verticillium wilt in monoculture using species distribution modeling.

    abstract:Background:Although integrated pest management (IPM) is essential for conservation agriculture, this method can be inadequate for severely infected fields. The ability to predict the potential occurrence of severe infestation of soil-borne disease would enable farmers to adopt suitable methods for high-risk areas, such...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10290

    authors: Ikeda K,Osawa T

    更新日期:2020-11-17 00:00:00

  • Clonal diversity and genetic variation of the sedge Carex nigra in an alpine fen depend on soil nutrients.

    abstract::In this study we analysed the impact of water regime and soil nutrients on the clonal diversity and genetic variation of the sedge Carex nigra in a central alpine fen. For our analysis, we established 16 study plots randomly distributed over the fen. We determined the exact elevation of each plot as an indicator for t...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8887

    authors: Reisch C,Meier S,Schmid C,Bartelheimer M

    更新日期:2020-06-03 00:00:00

  • Morphological convergence in 'river dolphin' skulls.

    abstract::Convergent evolution can provide insights into the predictability of, and constraints on, the evolution of biodiversity. One striking example of convergence is seen in the 'river dolphins'. The four dolphin genera that make up the 'river dolphins' (Inia geoffrensis, Pontoporia blainvillei, Platanista gangetica and Lip...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4090

    authors: Page CE,Cooper N

    更新日期:2017-11-21 00:00:00

  • Evaluation of the estimate bias magnitude of the Rao's quadratic diversity index.

    abstract::Rao's quadratic diversity index is one of the most widely applied diversity indices in functional and phylogenetic ecology. The standard way of computing Rao's quadratic diversity index for an ecological assemblage with a group of species with varying abundances is to sum the functional or phylogenetic distances betwe...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5211

    authors: Chen Y,Wu Y,Shen TJ

    更新日期:2018-07-06 00:00:00

  • The use of artificial substrate units to improve inventories of cryptic crustacean species on Caribbean coral reefs.

    abstract::Motile cryptofauna inhabiting coral reefs are complex assemblages that utilize the space available among dead coral stands and the surrounding coral rubble substrate. They comprise a group of organisms largely overlooked in biodiversity estimates because they are hard to collect and identify, and their collection caus...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10389

    authors: Monroy-Velázquez LV,Rodríguez-Martínez RE,Blanchon P,Alvarez F

    更新日期:2020-11-23 00:00:00

  • Bunyaviruses are common in male and female Ixodes scapularis ticks in central Pennsylvania.

    abstract::The blacklegged tick Ixodes scapularis is widely distributed in the United States and transmits multiple pathogens to humans, wildlife and domestic animals. Recently, several novel viruses in the family Bunyaviridae (South Bay virus (SBV) and Blacklegged tick phlebovirus (BTPV)) were identified infecting female I. sca...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2324

    authors: Sakamoto JM,Ng TFF,Suzuki Y,Tsujimoto H,Deng X,Delwart E,Rasgon JL

    更新日期:2016-08-11 00:00:00

  • A computational method for the systematic screening of reaction barriers in enzymes: searching for Bacillus circulans xylanase mutants with greater activity towards a synthetic substrate.

    abstract::We present a semi-empirical (PM6-based) computational method for systematically estimating the effect of all possible single mutants, within a certain radius of the active site, on the barrier height of an enzymatic reaction. The intent of this method is not a quantitative prediction of the barrier heights, but rather...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.111

    authors: Hediger MR,Steinmann C,De Vico L,Jensen JH

    更新日期:2013-07-23 00:00:00

  • How many species of mammals are there in Brazil? New records of rare rodents (Rodentia: Cricetidae: Sigmodontinae) from Amazonia raise the current known diversity.

    abstract:Background:Since 1996, when Vivo questioned how many species of mammals occur in Brazil, there has been a huge effort to assess this biodiversity. In this contribution, we present new records for rare species of the sigmodontine rodent genera Rhagomys and Neusticomys previously unknown to Brazilian Amazon. We provided ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4071

    authors: Percequillo AR,Dalapicolla J,Abreu-Júnior EF,Roth PRO,Ferraz KMPMB,Chiquito EA

    更新日期:2017-12-15 00:00:00

  • Towards evenly distributed grazing patterns: including social context in sheep management strategies.

    abstract::Background. A large proportion of natural grasslands around the world is exposed to overgrazing resulting in land degradation and biodiversity loss. Although there is an increasing effort in the promotion of sustainable livestock management, rangeland degradation still occurs because animals' foraging behaviour is hig...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2152

    authors: di Virgilio A,Morales JM

    更新日期:2016-06-21 00:00:00