Abstract:
:Circadian rhythms maintain a 24 h oscillation pattern in metabolic, physiological and behavioral processes in all living organisms. Circadian rhythms are organized as biochemical networks located in hypothalamus and peripheral tissues. Rhythmicity in the expression of circadian clock genes plays a vital role in regulating the process of cell division and DNA damage control. The oncogenic protein, MYC and the tumor suppressor, p53 are directly influenced by the circadian clock. Jet lag and altered sleep/wake schedules prominently affect the expression of molecular clock genes. This study is focused on developing a Petri net model to analyze the impacts of long term jet lag on the circadian clock and its probable role in tumor progression. The results depict that jet lag disrupts the normal rhythmic behavior and expression of the circadian clock proteins. This disruption leads to persistent expression of MYC and suppressed expression of p53. Thus, it is inferred that jet lag altered circadian clock negatively affects the expressions of cell cycle regulatory genes and contribute in uncontrolled proliferation of tumor cells.
journal_name
PeerJjournal_title
PeerJauthors
Hassan A,Ahmad J,Ashraf H,Ali Adoi
10.7717/peerj.4877subject
Has Abstractpub_date
2018-06-06 00:00:00pages
e4877issn
2167-8359pii
4877journal_volume
6pub_type
杂志文章相关文献
PeerJ文献大全abstract::Rao's quadratic diversity index is one of the most widely applied diversity indices in functional and phylogenetic ecology. The standard way of computing Rao's quadratic diversity index for an ecological assemblage with a group of species with varying abundances is to sum the functional or phylogenetic distances betwe...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5211
更新日期:2018-07-06 00:00:00
abstract::Streptococcus pneumoniae remains the leading causative pathogen in pediatric pneumonia and bacteremia throughout the world. The invasive pneumococcal disease (IPD) is known as isolation of S. pneumoniae from a normally sterile site (e.g., blood, cerebrospinal fluid, synovial fluid, pericardial fluid, pleural fluid, or...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2941
更新日期:2017-01-25 00:00:00
abstract::Previous research has shown that odorants consistently evoke associations with textures and their tactile properties like smoothness and roughness. Also, it has been observed that olfaction can modulate tactile perception. We therefore hypothesized that tactile roughness perception may be biased towards the somatosens...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.955
更新日期:2015-05-12 00:00:00
abstract::In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catche...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4707
更新日期:2018-05-17 00:00:00
abstract:Background:Despite clinical trials with antioxidant supplementation, few studies have been conducted to evaluate the nutritional status of antioxidant vitamins and minerals, and none have reported on the status of these serum antioxidants associated with the dietary intake of antioxidants by non-alcoholic fatty liver d...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9838
更新日期:2020-09-17 00:00:00
abstract:BACKGROUND:Algae encompass a wide array of photosynthetic organisms that are ubiquitously distributed in aquatic and terrestrial habitats. Algal species often bloom in aquatic ecosystems, providing a significant autochthonous carbon input to the deeper anoxic layers in stratified water bodies. In addition, various alga...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2803
更新日期:2017-01-10 00:00:00
abstract::Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment of diuresis, bacterial infections and cancer, as well as a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4170
更新日期:2017-12-20 00:00:00
abstract:Aims:Periodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study was a nationwide population-based retrospective cohort s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4064
更新日期:2017-11-16 00:00:00
abstract::Twist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However, the mechanism of androgen regulation of the Twist1 gene is not ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8921
更新日期:2020-04-09 00:00:00
abstract::In this study, we sequenced the genome of Pandoraea pnomenusa RB38 using Pacific Biosciences RSII (PacBio) Single Molecule Real Time (SMRT) sequencing technology. A pair of cognate luxI/R homologs was identified where the luxI homolog, ppnI, was found adjacent to a luxR homolog, ppnR1. An additional orphan luxR homolo...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1225
更新日期:2015-08-27 00:00:00
abstract::The emergence of herbicide-resistant weeds is a major threat facing modern agriculture. Over 470 weedy-plant populations have developed resistance to herbicides. Traditional evolutionary mechanisms are not always sufficient to explain the rapidity with which certain weed populations adapt in response to herbicide expo...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3560
更新日期:2017-07-20 00:00:00
abstract::The exploration of the evolution of RNA viruses has been aided recently by the discovery of copies of fragments or complete genomes of non-retroviral RNA viruses (Non-retroviral Endogenous RNA Viral Elements, or NERVEs) in many eukaryotic nuclear genomes. Among the most prominent NERVEs are partial copies of the RNA d...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.876
更新日期:2015-04-09 00:00:00
abstract::Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries. Drug-resistant TB is the most serious type of this burden. Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method. A total of 32 pairs of allele-specific PCR (AS-PCR)...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6696
更新日期:2019-04-01 00:00:00
abstract::Permineralized peat from the central Transantarctic Mountains of Antarctica has provided a wealth of information on plant and fungal diversity in Middle Triassic high-latitude forest paleoecosystems; however, there are no reports as yet of algae or cyanobacteria. The first record of a fossil filamentous cyanobacterium...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8660
更新日期:2020-03-02 00:00:00
abstract::The INDETERMINATE DOMAIN (IDD) gene family encodes hybrid transcription factors with distinct zinc finger motifs and appears to be found in all higher plant genomes. IDD genes have been identified throughout the genomes of the model plants Arabidopsis thaliana and Oryza sativa, and the functions of many members of thi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6628
更新日期:2019-03-26 00:00:00
abstract::It is deemed important to understand cetacean occurrence and distribution to comprehend their ecological roles. The geographical occurrence of species' niche can be used to better describe their potential distribution. The niche can be defined using environmental variables. Those variables are considered static and no...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10000
更新日期:2020-10-05 00:00:00
abstract:Background:The enriched environment (EE) is a laboratory housing model that emerged from efforts to minimize the impact of environmental conditions on laboratory animals. Recently, we showed that EE promoted positive effects on behavior and cortisol levels in zebrafish submitted to the unpredictable chronic stress (UCS...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5136
更新日期:2018-07-05 00:00:00
abstract::Flatfish undergo extreme morphological development and settle to a benthic in the adult stage, and are likely to be more susceptible to environmental stress. Heat shock proteins 70 (hsp70) are involved in embryonic development and stress response in metazoan animals. However, the evolutionary history and functions of ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7781
更新日期:2019-11-11 00:00:00
abstract::According to current molecular evidence, the Chionaspis pinifoliae heterophyllae species complex has been recognized as 10 cryptic species. In this study, we construct potential distribution maps for seven cryptic species based on climatic variables. This was done to assess the main environmental factors that have con...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7042
更新日期:2019-05-31 00:00:00
abstract::Science communication is seen as critical for the disciplines of ecology and conservation, where research products are often used to shape policy and decision making. Scientists are increasing their online media communication, via social media and news. Such media engagement has been thought to influence or predict tr...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4564
更新日期:2018-04-12 00:00:00
abstract::Afrotheria is a strongly supported clade within placental mammals, but morphological synapomorphies for the entire group have only recently come to light. Soft tissue characters represent an underutilized source of data for phylogenetic analysis, but nonetheless provide features shared by some or all members of Afroth...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1906
更新日期:2016-04-12 00:00:00
abstract::Web-spinning spiders that inhabit stream channels are considered specialists of aquatic ecosystems and are major consumers of emerging aquatic insects, while other spider taxa are more commonly found in riparian forests and as a result may consume more terrestrial insects. To determine if there was a difference in spi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1324
更新日期:2015-10-15 00:00:00
abstract:Background:Several authors have indicated that excess body weight can modify the electromyographic (EMG) amplitude due to the accumulation of subcutaneous fat. This accumulation of adipose tissue around the muscle would affect the metabolic capacity during functional activities. On the other hand, some authors have not...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7175
更新日期:2019-06-25 00:00:00
abstract::The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, is one of the most serious citrus pests worldwide due to its role as vector of huanglongbing or citrus greening disease. While some optimal plant species for ACP oviposition and development have been identified, little is known of the influence of host plants ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2663
更新日期:2016-11-03 00:00:00
abstract::Long-term streamflow datasets inevitably include gaps, which must be filled to allow estimates of runoff and ultimately catchment water budgets. Uncertainty introduced by filling gaps in discharge records is rarely, if ever, reported. We characterized the uncertainty due to streamflow gaps in a reference watershed at ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9531
更新日期:2020-07-21 00:00:00
abstract::We used qingbo (Spinibarbus sinensis) and Chinese crucian carp (Carassius auratus) to test whether numerical discrimination could be improved by the coexistence and possible cooperation of conspecies or heterospecies. We conducted a spontaneous shoal choice test of singletons, conspecific dyads and heterospecific dyad...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6619
更新日期:2019-03-11 00:00:00
abstract::Wildlife biologists often use grid-based designs to sample animals and generate abundance estimates. Although sampling in grids is theoretically sound, in application, the method can be logistically difficult and expensive when sampling elusive species inhabiting extensive areas. These factors make it challenging to s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.227
更新日期:2013-12-17 00:00:00
abstract:Background:The functional significance of ADAMs family members in the immune infiltration of pancreatic adenocarcinoma (PAAD) awaits elucidation. Methods:ADAMs family members with significant expression were identified among differentially expressed genes of PAAD based on The Cancer Genome Atlas (TCGA) database follow...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9736
更新日期:2020-09-30 00:00:00
abstract::Determining whether a population is introduced or native to a region can be challenging due to inadequate taxonomy, the presence of cryptic lineages, and poor historical documentation. For taxa with resting stages that bloom episodically, determining origin can be especially challenging as an environmentally-triggered...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3205
更新日期:2017-04-18 00:00:00
abstract:BACKGROUND:With their Pan-American distribution, long-nosed armadillos (genus Dasypus) constitute an understudied model for Neotropical biogeography. This genus currently comprises seven recognized species, the nine-banded armadillo (D. novemcinctus) having the widest distribution ranging from Northern Argentina to the...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3593
更新日期:2017-08-15 00:00:00