Abstract：
:The recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibitors. However, the clinical results with these agents have demonstrated variability in the response. Pancreatic cancer, in particular, has proven resistant to initial immunotherapy approaches. Here, we describe an alternative strategy that relies on combining gemcitabine and a novel programmed death-ligand 1 (PD-L1) inhibitor, termed MN-siPDL1. MN-siPDL1 incorporates small interfering RNA against PD-L1 (siPDL1) conjugated to a magnetic nanocarrier (MN). We show that noninvasive magnetic resonance imaging (MRI) could be used to monitor therapeutic response. Combination therapy consisting of gemcitabine and MN-siPDL1 in a syngeneic murine pancreatic cancer model resulted in a significant reduction in tumor growth and an increase in survival. Following optimization, a 90% reduction in tumor volume was achieved 2 weeks after the beginning of treatment. Whereas 100% of the control animals had succumbed to their tumors by week 6 after the beginning of treatment, there was no mortality in the experimental group by week 5, and 67% of the experimental animals survived for 12 weeks. This method could provide therapeutic benefit against an intractable disease for which there are no effective treatments and which is characterized by a mere 1% 5-year survival.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yoo B,Jordan VC,Sheedy P,Billig AM,Ross A,Pantazopoulos P,Medarova Zdoi
10.1038/s41598-019-41251-9subject
Has Abstractpub_date
2019-03-18 00:00:00pages
4712issue
1issn
2045-2322pii
10.1038/s41598-019-41251-9journal_volume
9pub_type
杂志文章abstract：:Bumblebees are exposed to pesticides applied for crop protection while foraging on treated plants, with increasing evidence suggesting that this sublethal exposure has implications for pollinator declines. The challenges of navigating and learning to manipulate many different flowers underline the critical role learni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16508
更新日期：2015-11-16 00:00:00
abstract：:Layered Li2RuO3 is an important candidate cathode material in rechargeable lithium ion batteries because of its novel anionic redox process and high reversible capacity. Atomistic scale simulations are used to calculate the intrinsic defect process, favourable dopants and migration energies of lithium ion diffusions t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36865-4
更新日期：2019-01-24 00:00:00
abstract：:Marine sponges are early-branching, filter-feeding metazoans that usually host complex microbiomes comprised of several, currently uncultivatable symbiotic lineages. Here, we use a low-carbon based strategy to cultivate low-abundance bacteria from Spongia officinalis. This approach favoured the growth of Alphaproteoba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38737-x
更新日期：2019-02-13 00:00:00
abstract：:Cells in vascular walls are exposed to blood pressure variability (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology. For example, BPV is elevated in hypertension but reduced under anesthesia. We hypothesized that the extent of mechanical fluctuations applied to vascu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57301-1
更新日期：2020-01-15 00:00:00
abstract：:This study aims to assess the utility of internet search query analysis in pertussis surveillance. This study uses an empirical time series model based on internet search metrics to detect the pertussis incidence in Australia. Our research demonstrates a clear seasonal pattern of both pertussis infections and Google T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11195-z
更新日期：2017-09-05 00:00:00
abstract：:Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62265-8
更新日期：2020-03-27 00:00:00
abstract：:Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33748-6
更新日期：2018-10-18 00:00:00
abstract：:Bone scan abnormalities, especially rib lesions, are often confusing for physicians due to a high number of false-positive lesions. This study investigated risk factors that are associated with bone metastasis in 613 breast cancer patients with bone scan abnormalities. Significantly increased rates of bone metastasis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09587
更新日期：2015-05-05 00:00:00
abstract：:The use of agrochemicals in vegetable production could influence the selection for insecticide resistance in malaria vectors. Unfortunately, there is a dearth of information on the potential contribution of agrochemicals to insecticide resistance in Anopheles mosquitoes breeding on vegetable farms in southern Benin. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63086-5
更新日期：2020-04-14 00:00:00
abstract：:Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44968-9
更新日期：2019-06-11 00:00:00
abstract：:Aldehyde dehydrogenase (ALDH) is a key enzyme for the catalytic oxidation of acetaldehyde to acetic acid. Genetic polymorphisms of ALDH2 have been associated with a wide range of diseases and cancers. However, little information is found about the association between ALDH2 polymorphisms and lumbar disc herniation (LDH...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31491-6
更新日期：2018-08-30 00:00:00
abstract：:The oxidative stress regulator Spx is ubiquitously found among Gram-positive bacteria. Previously, we reported identification of two Spx proteins in Streptococcus mutans - SpxA1 was the primary activator of oxidative stress genes whereas SpxA2 served a backup role. Here, we used RNA sequencing to uncover the scope of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16367-5
更新日期：2017-11-22 00:00:00
abstract：:Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18765-1
更新日期：2018-01-12 00:00:00
abstract：:Quantum Key Distribution is carving its place among the tools used to secure communications. While a difficult technology, it enjoys benefits that set it apart from the rest, the most prominent is its provable security based on the laws of physics. QKD requires not only the mastering of signals at the quantum level, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01576
更新日期：2013-01-01 00:00:00
abstract：:Sacrospinous ligament fixation (SSLF) is one of the most utilized surgeries in the management of pelvic organ prolapse (POP). We conducted a large-series study of SSLF in a tertiary center by an experienced urogynecologic team. The 453 women with POP who underwent SSLF at National Taiwan University Hospital in the per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61995-z
更新日期：2020-03-19 00:00:00
abstract：:Cyanobacteria are ubiquitous organisms with a relevant contribution to primary production in all range of habitats. Cyanobacteria are well known for their part in worldwide occurrence of aquatic blooms while producing a myriad of natural compounds, some with toxic potential, but others of high economical impact, as ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64774-y
更新日期：2020-05-26 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-50846-1
更新日期：2019-10-18 00:00:00
abstract：:A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silico...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07802
更新日期：2015-01-15 00:00:00
abstract：:This paper reports the presence of tear strips on the surface of a Ti-22Al-25Nb alloy sheet stretched at 960 °C. The test piece reveals a "bamboo"-shaped pattern on its surface, which severely affects the quality of the alloy. Microstructure analysis indicates that the formation mechanism of the tear strip is related ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01889-9
更新日期：2017-05-10 00:00:00
abstract：:Convergent-margin basins (CMBs) are commonly associated with active arcs, and hence are rich in detrital zircon (DZ) whose ages closely reflect the timing of deposition. Consequently, maximum depositional ages (MDA) from DZ geochronology can be employed to resolve the stratigraphy and evolution of CMBs. Herein, we use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51795-5
更新日期：2019-10-25 00:00:00
abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10524
更新日期：2015-05-22 00:00:00
abstract：:The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However, CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents, despite the evidence that vulnerability for many psychiatric disorders accumulates during early life. Here, we assessed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53624-1
更新日期：2019-11-22 00:00:00
abstract：:Arctic amplification of global warming has led to increased summer sea ice retreat, which influences gas exchange between the Arctic Ocean and the atmosphere where sea ice previously acted as a physical barrier. Indeed, recently observed enhanced atmospheric methane concentrations in Arctic regions with fractional sea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16179
更新日期：2015-11-10 00:00:00
abstract：:Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45298
更新日期：2017-04-07 00:00:00
abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65206-7
更新日期：2020-05-22 00:00:00
abstract：:Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52090-z
更新日期：2019-11-01 00:00:00
abstract：:Parkinson's Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson's patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39294-z
更新日期：2019-03-04 00:00:00
abstract：:Staphylococci are common causes of healthcare-associated and community-associated infections. However, limited data are available on the prevalence, phenotypes and molecular characteristics of Staphylococci in metro system around the world. 320 surface samples were collected from the Guangzhou metro system to isolate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16087
更新日期：2015-10-29 00:00:00
abstract：:The cuticle of the beetle Chrysina chrysargyrea reflects left-handed polarized light in the broad spectral range from 340 to 1000 nm. Interference oscillations in the experimental Mueller-matrix spectroscopic ellipsometry data reveal that transparent materials comprise the cuticle. A spectral analysis of the interfere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24761-w
更新日期：2018-04-24 00:00:00
abstract：:Surface and soil core samples from northeast China were analyzed for Pu isotopes. The measured (240)Pu/(239)Pu atomic ratios and (239 + 240)Pu/(137)Cs activity ratios revealed that the global fallout is the dominant source of Pu and (137)Cs at these sites. Migration behavior of Pu varying with land type and human acti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03506
更新日期：2013-12-16 00:00:00
