Abstract:
BACKGROUND:The reported prevalence of cognitive impairment in patients with stable chronic obstructive pulmonary disease (COPD) ranges 36-77%. Few studies report the prevalence of cognitive impairment in acutely unwell COPD patients. AIMS:To determine the prevalence and time course of cognitive impairment in patients with COPD during and after an admission to hospital with an exacerbation of the disease. METHODS:Patients admitted to hospital with an exacerbation of COPD between October 2013 and November 2014 were administered the Montreal Cognitive Assessment tool, COPD assessment test and modified Borg dyspnoea scale at three points in time: within 24 h of admission, between 48 and 72 h after admission and 6 weeks post discharge. RESULTS:Twenty-five patients agreed to participate. Four withdrew from the study after the initial evaluation. The mean (range) COPD assessment test score 24 h after admission was 26 (18-37). Cognitive impairment was found in 19/25 (76%) patients at the initial evaluation, 16/21 (76%) patients at the second evaluation. Overall, 22/25 (88%) showed cognitive impairment within 72 h of an exacerbation of COPD. Fourteen out of 21 (66%) patients showed cognitive impairment at the final evaluation. The mean Montreal Cognitive Assessment scores improved from admission (22.6) to the second evaluation (23.3) to the final evaluation 3 (24.4), but this change was not statistically significant. CONCLUSION:Cognitive impairment is highly prevalent during hospital admissions with an exacerbation of COPD. This impairment does improve with time, but only a minority recover within a normal range. This will affect patients' abilities to understand and remember information given to them in hospital and adhere to medication regimens.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Poot B,Travers J,Weatherall M,McGinty Mdoi
10.1111/imj.14259subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1307-1312issue
10eissn
1444-0903issn
1445-5994journal_volume
49pub_type
杂志文章abstract:BACKGROUND:The role of brentuximab peri-allogeneic transplantation in patients with relapsed and/or refractory CD30 positive lymphomas remains poorly defined. AIM:To assess the outcome of use of brentuximab as a bridge to allogeneic stem cell transplantation (SCT) in patient with relapsed/refractory CD30+ classic Hodg...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13415
更新日期:2017-05-01 00:00:00
abstract::Diabetes mellitus (DM) has been found to be associated with cardiovascular disease. The goal of this study is to evaluate the prevalence of asthma in patients with type II DM after adjusting for other comorbid conditions. We used patient treatment files of inpatients' admissions containing discharge diagnosis (Classif...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01976.x
更新日期:2009-10-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a rare disease affecting women, classically involving the lungs. However, extrapulmonary manifestations also occur, including renal angiomyolipomas, retroperitoneal lymphangioleiomyomas and extrathoracic lymphadenopathy. The lung disease is hormone-responsive, but no information exist...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2011.02593.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Timely administration of intravenous tissue plasminogen activator (IVtPA) for acute ischaemic stroke is associated with better clinical outcomes. Therefore, a coordinated hospital system of acute clinical assessment and neuroimaging will likely avoid delays in IV-tPA administration. AIM:In July 2007, we imp...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2011.02709.x
更新日期:2012-12-01 00:00:00
abstract::Neuroimaging in dementia has focused on documenting any burden of vascular disease or excluding any reversible intracranial pathology. We review the use of computed tomography to examine for medial temporal lobe atrophy in dementia and compare this with a case series of such measurements from our memory clinic. Measur...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2007.01598.x
更新日期:2008-02-01 00:00:00
abstract::This article reports the findings of a survey developed to assess the current use of antifungal prophylaxis among haematology and infectious disease clinicians across Australia and New Zealand, and their alignment with existing consensus guidelines for the use of antifungal agents in the haematology/oncology setting (...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12594
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:A generalized epidemic of HIV infection has been evolving in Papua New Guinea over the last decade, whereas in other Pacific Island countries and territories (PICT) HIV transmission has generally been less widespread. Programmes to detect HIV infection in pregnant women and to prevent mother to child trans...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01309.x
更新日期:2007-04-01 00:00:00
abstract::The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1046/j.1445-5994.2001.00068.x
更新日期:2001-08-01 00:00:00
abstract::As life expectancy for people living with human immunodeficiency virus (HIV) (PLWHIV) increases, management models for HIV infection are changing. To understand approaches to practice within this shifting climate and across different medical settings, in 2017 we conducted a baseline survey among the main medical pract...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15129
更新日期:2020-12-01 00:00:00
abstract:AIM:To evaluate New Zealand media articles on their coverage of key issues regarding health interventions and whether it is consistent with available evidence. METHODS:A retrospective analysis was carried out of all articles published in five New Zealand media sources over a 6-week period between 15 October and 26 Nov...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13936
更新日期:2018-08-01 00:00:00
abstract::Growth hormone (GH) replacement therapy was recently recommended by the Pharmaceutical Benefits Advisory Committee (PBAC) for listing on the Pharmaceutical Benefits Scheme for adults with severe GH deficiency and impaired quality of life. This approval was significant for two reasons. First, the application was initia...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13943
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Eosinophilic esophagitis (EoE) is a newly recognised condition that is apparently increasing in prevalence, and the aetiology is poorly understood. The role of aeroallergens in EoE is controversial, given the success of dietary therapy. Massive aeroallergen exposure leading to food bolus obstruction events (...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究
doi:10.1111/imj.12790
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Anticipating the prospect of specific treatment, we studied a large group of Australians with Fabry's disease. AIMS:We aimed to: (i) document the clinical features of Fabry's disease in Australian patients, (ii) test the hypothesis that clinical features vary with specific mutation and blood group and (iii)...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2002.00291.x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The current results on the diagnostic accuracy of multidetector computed tomography (MDCT) in the detection of left atrial/left atrial appendage (LA/LAA) thrombus are conflicting. AIM:The aim of the present study was to determine the diagnostic accuracy of MDCT in LA/LAA thrombus with meta-ana...
journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析
doi:10.1111/j.1445-5994.2012.02932.x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The cost of diabetes is high for both the individual and society. Future health-care planning requires patient-level diabetes-attributable health-care cost data that have not previously been available for Australia. AIM:To determine Australian national direct diabetes-attributable health-care costs for know...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01014.x
更新日期:2006-03-01 00:00:00
abstract::Chronic lead exposure is recognized as a potential cause of hyperuricaemia, kidney damage and hypertension. The fascinating story of lead poisoning and nephrotoxicity illustrates the utility of descriptive studies in the early elucidation of a new disease entity. The pursuit towards understanding lead nephropathy is p...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1111/j.1445-5994.2006.01181.x
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Informed consent is a mainstay of clinical practice, with both moral and legal forces. Material disclosure about extreme treatments, however, is unlikely to convey the full impact of the experience of treatment. Informed consent may be flawed under such circumstances. The aims of this study were to compare e...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2008.01700.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The short Synacthen test is widely used to assess the hypothalamus pituitary adrenal axis in the outpatient setting. In the inpatient setting however, technical difficulties to adhere to the protocol may pose a challenge for using this test. AIMS:In this study we attempted to find the most suitable basal se...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15033
更新日期:2020-08-24 00:00:00
abstract:INTRODUCTION:In patients with chronic idiopathic thrombocytopenic purpura (cITP), the platelet count tends to be quite variable and, in the majority of cases, specific therapy is not warranted on a regular basis. However, patients with low platelet count (<30 nL) or with bleeding complications would require therapy, su...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12794
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the structural and functional effects of autologous stem cell transplantation (ASCT) on scleroderma finger clawing. METHODS:Using photocopies of hands of five scleroderma patients who underwent ASCT using photocopies of hands. Functional assessments used a standardized que...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01593.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Rhabdomyolysis (RB) is a syndrome characterised by decomposition of skeletal muscle that could be life threatening, so the identification of biomarkers of its severity could help us in its treatment. Creatine kinase (CK) is usually taken as a reference in patients with RB in order to stratify prognosis, howe...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12815
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Trends in the incidence of acute myocardial infarction (AMI) provide important information for healthcare providers and can allow for accurate planning of future health needs and targeted interventions in areas with an excess burden of cardiovascular disease. AIM:To investigate the regional variations in AM...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13399
更新日期:2017-05-01 00:00:00
abstract::An acute pulmonary embolism (aPE) is characterised by occlusion of one or more pulmonary arteries. Physiological disturbance may be minimal, but often cardiac output decreases as the right ventricle attempts to overcome increased afterload. Additionally, ventilation-perfusion mismatches can develop in affected vascula...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.14145
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Several epidemiological studies have suggested a positive association of coronary heart disease with both Helicobacter pylori and Chlamydia pneumoniae infection. The issue has been difficult to resolve because of the potential impact of several confounding factors, in particular, socioeconomic status for H. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00349.x
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Quick Sepsis-related Organ Failure Assessment (qSOFA) is recommended for use by the most recent international sepsis definition taskforce to identify suspected sepsis in patients outside the Intensive Care Unit (ICU) at risk of adverse outcomes. Evidence of its comparative effectiveness with existing sepsis ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14746
更新日期:2020-01-06 00:00:00
abstract::A prospective study of non-invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory f...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13632
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND: Alcoholic liver disease (ALD) is an important contributor to the total burden of alcohol-related harm; however, the morbidity of different types of ALD in Australia has not been described. The aim of this study was to investigate recent trends in hospital admission rates among alcoholic liver cirrhosis, al...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02279.x
更新日期:2011-01-01 00:00:00
abstract::5-aminosalicylates (5-ASA) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12240
更新日期:2013-10-01 00:00:00
abstract::This paper uses a case example to review the current legal status of advance directives, as well as their ethical rationale. We draw attention to ongoing efforts to institutionalize advance directives, and to some of the tractable and intractable reasons why advance directives are ineffective. We then introduce the co...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2005.00915.x
更新日期:2005-09-01 00:00:00
abstract::The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13611
更新日期:2017-11-01 00:00:00