Abstract:
:Neuronal migration is a crucial event in neuronal development for the construction of brain architecture and neuronal networks. Newborn neurons proliferate in the germinal zone and start migration toward their final destination. Migrating neurons adopt different routes, cell shapes and migratory modes depending on extracellular factors and outer physical substrates. Intracellular Ca2+ is an essential second messenger that regulates diverse cellular functions by activating Ca2+-dependent signalling molecules that underlie Ca2+-responsive cellular functions. Neuronal migration during brain architecture construction is no exception. Spontaneous Ca2+ transients are observed in several types of migrating neurons, and a series of Ca2+-dependent signalling molecules governing neuronal migration has been identified. In this review, we first summarize the molecular mechanisms that trigger intracellular Ca2+ elevation in migrating neurons. In the latter half of this review, we provide an overview of the literature on Ca2+-dependent signalling molecules underlying neuronal migration.
journal_name
J Biochemjournal_title
Journal of biochemistryauthors
Horigane SI,Ozawa Y,Yamada H,Takemoto-Kimura Sdoi
10.1093/jb/mvz012subject
Has Abstractpub_date
2019-05-01 00:00:00pages
401-409issue
5eissn
0021-924Xissn
1756-2651pii
5316037journal_volume
165pub_type
杂志文章,评审abstract::Human promyelocytic leukemia cells (HL-60) were treated with several differentiation inducers, then the changes in the activity of cytosolic protein kinase C (PKC) isoforms were examined by hydroxylapatite chromatography and the species of the isoforms were determined immunologically. In three undifferentiated HL-60 c...
journal_title:Journal of biochemistry
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1978-12-01 00:00:00
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更新日期:1988-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of biochemistry
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a021757
更新日期:1997-08-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a124579
更新日期:1994-09-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a132080
更新日期:1978-06-01 00:00:00
abstract::beta-Glycosidase from the extreme thermophilic archaeon Sulfolobus solfataricus is a tetrameric protein with a molecular mass of 240 kDa, stable in the presence of detergents, and with a maximal activity at temperatures above 95 degrees C. Understanding the structure-activity relationships of the enzyme under differen...
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a022484
更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-12-01 00:00:00
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更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00