Abstract：
:Gabapentin, a GABA analogue, is a nonopioid prescribed for seizure control and neuralgic pain. Its abuse for recreational purposes has been increasing in recent years as the number of prescriptions also increases. In our series, we review 104 cases of decedents who tested positive for gabapentin in postmortem blood samples and an additional 53 nonfatal cases of motor vehicle drivers suspected of driving under the influence. In 47.1% of the fatality cases, gabapentin was directly involved in death. Most gabapentin fatalities had several other intoxicants present (opioids, over-the-counter medications, antianxiety, and antidepressant medications). In cases in which gabapentin was determined to be a cause of death, the blood concentrations ranged from 1.1 to 134.0 mg/L. Persons who died of a gabapentin-related drug death were prescribed the drug legitimately 91.4% of the time, with 84.2% of those also having a known prior history of abuse or misuse of prescription medications.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Tharp AM,Hobron K,Wright Tdoi
10.1111/1556-4029.14021subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1105-1111issue
4eissn
0022-1198issn
1556-4029journal_volume
64pub_type
杂志文章abstract：:Estimation of the time since death (postmortem interval [PMI]) is one of the most difficult problems in forensic investigations, and many methods currently are utilized to estimate the PMI. The goal of this study was to investigate the changes of attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectr...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.02036.x
更新日期：2012-05-01 00:00:00
abstract：:In 2012, the Harris County Institute of Forensic Sciences began prospectively collecting injury data from pediatric autopsies. These data and associated case information from 635 pediatric cases are archived in the Infant Injury Database (IID). This paper introduces the IID to the forensic community and demonstrates i...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.14120
更新日期：2019-11-01 00:00:00
abstract：:A rapid, accurate, precise, reproducible, economical, and environmentally gentle method using capillary electrophoresis (CE) is presented for the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocaine in seized drugs. The methodology uses a 32 cm by 50 microm capillary (length to detector 23.5 ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Face recognition systems aim to recognize the identity of a person depicted in a photograph by comparing it against a gallery of prerecorded images. Current systems perform quite well in controlled scenarios, but they allow for none or little interaction in case of mistakes due to the low quality of images or to algor...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.02018.x
更新日期：2012-05-01 00:00:00
abstract：:A rapid, semiautomated radioimmunoassay system for detection of morphine, barbiturates, and amphetamines is described. The assays are applicable to large drug abuse screening programs. The heart of the system is the automatic pipetting station which can accomplish 600 pipetting operations per hour. The method uses 15 ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
abstract：:This paper reports the case of a 22-year-old white male who was found dead in a storage room as a result of a fatal ingestion of cyclopropane. Cyclopropane is a sweet-smelling, irritating gas. Autopsy findings revealed congestion and hemorrhagic edema of the lungs, congestion of the trachea, and early autolysis. Cyclo...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Four individuals died as the result of a propane explosion. As with many propane explosions, the question was raised as to the adequacy of the product's odorization after the autopsy studies had been conducted. In most cases, this question leads to litigation. Ethyl mercaptan is a widely used odorant for propane and w...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Two groups of offenders, one charged with sex crimes as well as with crimes of larceny, and the other charged with sex crimes only, are compared with respect to their demographic characteristics and their intelligence and diagnostic classification as determined via psychological testing. ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The paper describes the use of the Polilight, a light source based on a xenon arc lamp, to exploit the fluorescence properties of semen as an aid to searching fabrics for stains in sexual assault cases. The broad excitation spectrum of semen allows the fluorescence to be generated at a range of wavelengths. This permi...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:The scientific community and the judicial system are different components of society with different structures and functions. Nevertheless, science can contribute relevant and useful information to judicial deliberations if the inherent limitations of that information are understood. These limitations stem from the wa...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Teeth development is widely used for age estimation in forensic science. The aims of this study were as follows: first, to establish Indian data on canine and first premolar development for age estimation and second, to investigate population differences in teeth development. Orthopantomograms of 340 Indian children a...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2012.02111.x
更新日期：2012-07-01 00:00:00
abstract：:Measurements of the type and concentration of propellant and stabilizer additives in smokeless gunpowder are used by forensic scientists investigating the source of explosives and by military laboratories assuring the safety and efficacy of munitions. The National Institute of Standards and Technology recently assesse...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:Identification of sex from skeleton parts is of paramount importance to medicolegal investigations. The present study makes an attempt to assess sex from the ulna by devising new measurements for fragmentary bones. Dry and adult ulnae (100 male and 60 female) of Madhya Pradesh, India were subjected to three measuremen...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:A case is presented where phentermine, a sympathomimetic amine used as an anorectic drug, is believed to have significantly contributed to the death of an individual in whom other drugs were also found. Blood, urine, and tissue concentrations of phentermine are reported and compared to other cases in the literature. ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:The recent use of the postal system as a means of delivering anthrax spores via several contaminated envelopes has led to the selective irradiation of mail. These as yet unsolved attacks and the U.S. Postal Service's decision to irradiate certain types of mail has led to some unexpected complications. The high doses o...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:DNA profiling using STRs on the 310 and 3100 Genetic Analyzers routinely generates electropherograms that are analyzed with the GeneScan software available from the instrument's manufacturer, Applied Biosystems. Users have been able to choose from three different smoothing options that have been known to result in sig...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Erythrocyte acid phosphatase is a useful system for the crime laboratory for both fresh and degraded blood and bloodstains, provided the inherent problems of phenotyping this particular enzyme system are recognized. Because of the great number of variables affecting this enzyme system in vitro, phenotyping should not ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1978-07-01 00:00:00
abstract：:Inks from seven black and eight blue ballpoint pens were separated by a high-performance liquid chromatography (HPLC) method utilizing a photodiode array detection (PDA). A classifier flowchart was designed for the chromatographic data based on the presence or absence of certain peaks at different wavelengths to quali...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Over the past decade, there has been a growing openness about the importance of human factors in forensic work. However, most of it focused on cognitive bias, and neglected issues of workplace wellness and stress. Forensic scientists work in a dynamic environment that includes common workplace pressures such as worklo...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13533
更新日期：2018-01-01 00:00:00
abstract：:Haptoglobin typing by vertical electrophoresis in a discontinuous polyacrylamide gel was conducted on 47 dog blood samples, of which 19 were from Doberman pinschers, 20 from German shepherds, and 8 from pit bullterriers. Two phenotypes were common in the three breeds and could not be used to differentiate between them...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:Age estimation methods are often based on the age-related morphological changes of the auricular surface and the pubic bone. In this study, a mathematical approach to quantify these changes has been tested analyzing the curvature variation on 3D models from CT and laser scans. The sample consisted of the 24 Suchey-Bro...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12689
更新日期：2015-05-01 00:00:00
abstract：:Owing to the scanty evidence on usefulness of information of appearance of gray hair for age estimation, this study was conducted to estimate age based on the appearance of gray hair on different body sites in a sample of autopsy cases in Sri Lanka. A descriptive cross-sectional study was conducted in Teaching Hospita...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13375
更新日期：2017-07-01 00:00:00
abstract：:Compositional analysis of the organic additives in smokeless handgun powder can provide forensic information to associate known and questioned samples. A reliable method for the quantitative extraction of smokeless powder additives would strengthen these measurements. To achieve quantitative recovery, both supercritic...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:The purpose of this paper is to investigate the utility of digital dental radiographic superimposition in the various stages of development of the human dentition. Digital, computer assisted dental identification is a means of identification which allows the spatial relationships of the root and support structures of ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:An improved gas chromatographic/mass spectrometric (GC/MS) assay is described for the quantitation of codeine and morphine as trimethylsyl (TMS) derivatives. The TMS derivatization of ketone-containing opiates results in the formation of multiple derivatives. Some of these products have retention times close to those ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:This paper's objective is to describe two cases of fatal commotio cordis resulting from the deliberate striking of children's chests by adults with their fists. These deaths involve two male children, ages 3 years and 14 months. The clinical histories, events in the households prior to the deaths, behaviors of the chi...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:A 26-year-old woman committed suicide by ingestion of a large quantity of tocainide, a recently developed oral antiarrhythmic agent with chemical similarities to lidocaine. Blood and bodily fluid analysis by thin-layer chromatography, high pressure liquid chromatography, and mass spectroscopy confirmed the presence of...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Four cases of in-custody or unlawful death are presented as examples of increased bone fragility with an associated increase in fracture rates due to ethanol-induced osteopenia. In addition, one of the individuals suffered fractures several weeks premortem, allowing some healing to take place. Using radiographs and ph...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12150
更新日期：2013-07-01 00:00:00
abstract：:In postmortem drug analysis, the most commonly used sample matrix is whole blood. However, postmortem changes can denature this matrix, resulting in a loss or degradation of drugs, thus biasing analytical findings. Vitreous humor is thought to be less affected by these changes and should, therefore, have the potential...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Gunshot backspatter comprises biological material expelled backward through bullet entry holes. Crime scene investigators analyze backspatter patterns to infer wounding circumstances. An understanding of the mechanism of backspatter generation, and the relationship between spatter patterns and bullet and tissue charac...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2012.02143.x
更新日期：2012-09-01 00:00:00
