Abstract:
:Men with hypertension often develop erectile dysfunction (ED). The present study aimed to examine the effects of sodium hydrosulphide (NaHS), a hydrogen (H2 S) donor, treatment on ED in nitric oxide synthase (NOS) inhibitor (L-NAME)-induced hypertensive rats. Forty adult Sprague-Dawley rats were divided into four groups: control, NaHS (0.037 mg kg day-1 )-treated control, L-NAME-induced hypertension (40 mg kg day-1 ) and NaHS-treated L-NAME-induced hypertension. The ratio of intracavernosal pressure to mean arterial pressure and isometric tension of corpus cavernosum (CC) were measured. The penile expression of endothelial and neuronal NOS (eNOS and nNOS), inflammation markers [nuclear factor kappa B (NF-κB) and inhibitor kappa B alpha (IκBα)], H2 S-producing enzymes[cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)], the smooth muscle/collagen ratio and H2 S concentrations were determined. The blood pressure was significantly increased in the hypertensive group, but not reversed by NaHS. The erectile response in hypertensive rats was partially prevented by NaHS. The relaxation response to electrical field stimulation was increased in CC from NaHS-treated hypertensive rats. NaHS treatment restored decreased protein expression of eNOS, nNOS and CSE as well as smooth muscle/collagen ratio and H2 S levels and increased NF-κB and IκBα protein expression in the penile tissue of hypertensive rats. NaHS promoted the recovery of erectile responses in hypertensive rats by improvement of neuronal function and downregulation of fibrosis and NF-κB signalling.
journal_name
Andrologiajournal_title
Andrologiaauthors
Yilmaz E,Kaya-Sezginer E,Yilmaz-Oral D,Cengiz T,Bayatli N,Gur Sdoi
10.1111/and.13240subject
Has Abstractpub_date
2019-06-01 00:00:00pages
e13240issue
5eissn
0303-4569issn
1439-0272journal_volume
51pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::The sex chromosome-discordant chimerism 46,XX/46,XY is rarely found in humans with a phenotypically normal appearance, and this lack of phenotypic changes and the rarity of chimerism make it difficult to identify its exact incidence. Here, we report a case of this sex chromosome-discordant chimerism diagnosed by cytog...
journal_title:Andrologia
pub_type:
doi:10.1111/and.13215
更新日期:2019-04-01 00:00:00
abstract::Incubation of human sperm from semen with counts below 20 x 10(6)/ml with peanut agglutinin (PNA) resulted in agglutination of about 70% of sperm. An inverse correlation was found between non-agglutinating (PNA) sperm and sperm density (r = 0.48, p less than 0.01) and a direct correlation with acrosome-damaged sperm (...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb01970.x
更新日期:1990-05-01 00:00:00
abstract::The aim of this study was to investigate the relationship between sulphur dioxide (SO2 ) signalling pathway and the changes in erectile function under low androgen levels. Thirty-six healthy male Sprague Dawley (SD) rats aged eight weeks were randomly divided into androgen replacement group, castration group and sham ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13167
更新日期:2019-02-01 00:00:00
abstract::Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01043.x
更新日期:2011-10-01 00:00:00
abstract::Previous studies showed that exposure to stress or nicotine induced reproductive impairment in male rats. Here, we assessed the effect of an antioxidant (vitamin E) on nicotine-, stress- and nicotine + stress-induced reproductive impairment in male rats. Forty-eight male albino Wistar rats were divided into eight grou...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13050
更新日期:2018-09-01 00:00:00
abstract::This study was performed to investigate the effect of propylthiouracil (PTU) on rat testis, and to compare the results of the different treatment regimens of levothyroxine and zinc. Twenty sexually mature Wistar albino rats were subjected to PTU for 14 days intraperitoneally to make them hypothyroidic. The effect of P...
journal_title:Andrologia
pub_type: 杂志文章,收录出版
doi:10.1046/j.1439-0272.2000.00324.x
更新日期:2000-03-01 00:00:00
abstract::Definition of chronic male genital tract inflammation and its impact on male infertility is still a matter of debate. In particular, DNA integrity has been reported to be disturbed in subfertile men. Thus, the aim of this study was to investigate an association of DNA integrity to altered standard semen parameters as ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12408
更新日期:2015-05-01 00:00:00
abstract::A global increase in the incidence of subfertility is observed, and research suggests strong genetic influences that might restrict fertility directly or indirectly. It therefore becomes important to rule out the existence of genetic causes and counsel infertile couples before offering "Advanced Infertility Treatment ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13434
更新日期:2019-11-01 00:00:00
abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01281.x
更新日期:2012-10-01 00:00:00
abstract::Approximately between 9 and 19 years of age 28 adolescents with one and 26 with both retractile testicles were andrologically examined and followed up. Retractile gonads during puberty often remained of subnormal size with the long axis shorter than 34 mm. In both groups in 50 to 60% of cases low sperm values were asc...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::Testicular torsion is a urology urgent disease which causes testicular injury and potential sterility. In this study, we explored the protective influence of rosiglitazone on testicular ischaemia-reperfusion damage. There were 28 male Sprague Dawley rats in total, which were assigned randomly to four groups. Group A w...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12947
更新日期:2018-01-09 00:00:00
abstract::Structural heterozygosities of the karyotype have detrimental effects on the meiotic process, resulting very often in impairment of fertility in the carriers. Both male and female germ cell development are affected by chromosomal variability although spermatogenesis seems particularly prone to be affected, probably be...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1992.tb02601.x
更新日期:1992-01-01 00:00:00
abstract::The aim of this study was to comprise the effect of catalase on sperm parameters and chromatin in normospermic persons. Semen samples were obtained from fertile men. A certain amount of different concentrations of catalase (0.1, 1, 10, 50, 100, 150 and 200 IU.ml) was added to each vial containing semen. Control group ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13231
更新日期:2019-05-01 00:00:00
abstract::Based on the synchronization between a periodic vibration and flashing light, we designed a device to determine the flagellar beating frequency of human sperm. The head of a spermatozoon was either held by the tip of a micropipette operated with a micromanipulator or adhered by itself on the surface of a glass slide w...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1998.tb01382.x
更新日期:1998-02-01 00:00:00
abstract::The new electronic spermcounter was developed to make andrological routine work easier. The apparatus is a complete microcomputer and has three main functions: The counter function allows to determine the number of spermatozoa and round cells at the same time. The morphological function allows the detailed morphologic...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Anatomical endoscopic enucleation of the prostate (AEEP) differs from other surgical techniques for benign prostatic obstruction (BPO) in that it removes the entire benign prostatic hyperplasia (BPH) component of the prostate. We summarise the main advantages of AEEP compared to other surgical techniques for BPO. Thes...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13643
更新日期:2020-09-01 00:00:00
abstract::Sex hormones have been proposed as a possible risk factor for the development and growth of meningiomas. Hormonal therapy plays a fundamental role in the treatment of male-to-female transgenders and needs to be continued after sex reassignment surgery. Usually, this treatment leads to no adverse events; however, its i...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.12550
更新日期:2016-12-01 00:00:00
abstract::Open and double-blind therapeutic studies were carried out on the effects of tamoxifen in oligozoospermia. The examinations involved 74 patients. The first group (n = 20) received tamoxifen 20 mg/day; the second group (n = 54) got tamoxifen or placebo for 3 months. In the open study, tamoxifen treatment led to signifi...
journal_title:Andrologia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1439-0272.1985.tb01048.x
更新日期:1985-09-01 00:00:00
abstract::Bisphenol A (BPA), an organic synthetic compound and endocrine disruptor, which majorly cause deleterious effects on male reproductory system. Fenugreek (Trigonella foenum-graecum), associated with Leguminosae family is used as a herbal medicine with potent antioxidant properties. The present study was aimed to scruti...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13492
更新日期:2020-03-01 00:00:00
abstract::The present study summarizes a four-year follow-up of 20 production workers with D.B.C.P.-induced testicular dysfunction. In 4 of the 13 initially azoospermic men, sperm density increased to 1.5 to 48.0 millions/ml. Five of the seven initially oligozoospermic workers showed a marked increase in sperm count. In all the...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1983.tb00132.x
更新日期:1983-03-01 00:00:00
abstract::Sperm cell plasma membrane and the outer acrosomal membrane fuse profusely during the acrosome reaction. The process is triggered by extracellular signals that elicit several intracellular events leading ultimately to membrane fusion. We have developed a streptolysin O permeabilizing protocol that selectively affects ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02753.x
更新日期:1996-01-01 00:00:00
abstract::Penile amputation is an uncommon condition for which immediate surgical replantation is warranted. This work aimed to represent intervention and management for an amputated penis by replantation and reconstruction. A 23-year-old man presented with traumatic penile amputation for 2 h where the penile proximal part was ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2009.00925.x
更新日期:2009-08-01 00:00:00
abstract::This investigation was carried out to study the correlation of sperm quality parameters with antioxidant and oxidant status of buffalo bull semen during various stages of cryopreservation. Semen samples were evaluated for sperm parameters (mass motility [MM], concentration [CON], progressive motility [PM], viability [...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12970
更新日期:2018-02-11 00:00:00
abstract::Nonorganic erectile dysfunction is a problem with unknown central mechanisms. Changes in brain activity in the amygdala have been observed in human patients. This study aimed to investigate the dopamine system in the basolateral amygdala of male rats with nonorganic erectile dysfunction. We applied chronic mild stress...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13160
更新日期:2019-02-01 00:00:00
abstract::The role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the control of FSH and LH secretion was analysed in prepubertal male rats. In the first experiment 4, 8, 12, 16, 20 and 30-day-old males were decapitated 15 min after vehicle, NMDA or kainic acid (KA) administration. In the second experiment, 23-day-old...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02776.x
更新日期:1996-05-01 00:00:00
abstract::Linear mucus penetration of spermatozoa from 75 arbitrary selected men was evaluated using a non-commercial bovine cervix mucus preparation in the same way as Penetrak, but using round glass capillary tubes instead of flat plastic tubes. The mean penetration value was 28.7 +/- 7.10 mm in 90 min and the mean sperm dens...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Studies assessing the efficacy of intralesional verapamil injection in the treatment of Peyronie's disease have yielded mixed results. The purpose of this meta-analysis is to systematise the existing literature on the efficacy of intralesional verapamil injection when used in the treatment of Peyronie's disease. The t...
journal_title:Andrologia
pub_type: 杂志文章,meta分析
doi:10.1111/and.13388
更新日期:2019-11-01 00:00:00
abstract::Epididymal sperm reserve was determined in 6 sexually mature fertile buffalo-bulls having normal process of spermatogenesis. The relative distribution of spermatozoa in the caput, corpus and cauda epididymidis averaged 5.42, 0.75 and 11.45 billion respectively. Total epididymal sperm reserve per bull averaged 36.2 bil...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1978.tb03076.x
更新日期:1978-11-01 00:00:00
abstract::Chronic inflammatory conditions of the genital tract are still unsatisfactorily recognised in the workup of male infertility due to inappropriate definitions and inconsistent diagnostic criteria. The most popular term used for description of both, infections and inflammation in the genital tract is MAGI (male accessor...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13207
更新日期:2019-04-01 00:00:00
abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with glutamate carboxypeptidase activity. However, its precise function in the prostate, prostasomes and seminal plasma with regard to male fertility remains unknown. This study was conducted to investigate the seminal plasma PSMA levels in fert...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13840
更新日期:2021-02-01 00:00:00