Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.


:Nonorganic erectile dysfunction is a problem with unknown central mechanisms. Changes in brain activity in the amygdala have been observed in human patients. This study aimed to investigate the dopamine system in the basolateral amygdala of male rats with nonorganic erectile dysfunction. We applied chronic mild stress to induce nonorganic erectile dysfunction. After exposure to chronic mild stress, the sucrose consumption test, sexual behaviour test and apomorphine test were used to select depression-like rats with erectile dysfunction as nonorganic erectile dysfunction model rats. The sexual behaviour of these rats after central infusion of a dopamine D1/D2 receptor agonist/antagonist was observed. The expression levels of dopamine D1/D2 receptors and tyrosine hydroxylase in the basolateral amygdala were also measured. The result of the sucrose consumption test, sexual behaviour test and apomorphine test indicated a successful nonorganic erectile dysfunction model. Central infusion of a dopamine D2 receptor agonist increased intromission ratio in model rats. Lower expression levels of tyrosine hydroxylase and the dopamine D2 receptor in the basolateral amygdala were observed in rats with nonorganic erectile dysfunction. These results suggest that impairment of the dopamine D2 receptor pathway in the basolateral amygdala may contribute to the development of nonorganic erectile dysfunction.






Chen G,Chen J,Yang B,Yu W,Chen Y,Dai Y




Has Abstract


2019-02-01 00:00:00












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    pub_type: 杂志文章


    authors: Bhardwaj N,Rastogi P,Attri VS,Bora GS,Gorsi U

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Acute bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: andrological implications.

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    pub_type: 杂志文章,评审


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    更新日期:2008-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1975-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Dhabuwala CB,Kumar A,Pierce JM

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    pub_type: 杂志文章


    authors: Gholami Jourabi F,Yari S,Amiri P,Heidarianpour A,Hashemi H

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  • Separation of sub-populations of sperm with higher fertility potential from normal and pathological semen by peanut agglutinin.

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    pub_type: 杂志文章


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    更新日期:1990-05-01 00:00:00

  • Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility.

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    pub_type: 杂志文章


    authors: El-Maddawy ZK,Abd El Naby WSH

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    authors: Khayamabed R,Tavalaee M,Taherian SS,Nasr-Esfahani MH

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  • Efficacy and safety of testosterone replacement gel for treating hypogonadism in men: Phase III open-label studies.

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    pub_type: 杂志文章,多中心研究


    authors: Belkoff L,Brock G,Carrara D,Neijber A,Ando M,Mitchel J

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  • Serum prolactin concentration in impotent African males.

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    pub_type: 杂志文章


    authors: Modebe O

    更新日期:1989-01-01 00:00:00

  • Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men.

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    pub_type: 杂志文章


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    authors: Laurentino SS,Pinto PI,Tomás J,Cavaco JE,Sousa M,Barros A,Power DM,Canário AV,Socorro S

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,meta分析


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    pub_type: 杂志文章


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