Treatment of oligozoospermia with tamoxifen (open and controlled studies).

Abstract:

:Open and double-blind therapeutic studies were carried out on the effects of tamoxifen in oligozoospermia. The examinations involved 74 patients. The first group (n = 20) received tamoxifen 20 mg/day; the second group (n = 54) got tamoxifen or placebo for 3 months. In the open study, tamoxifen treatment led to significant increases in the spermatozoa concentration and the total sperm count, but this could not be confirmed with the double-blind set-up.

journal_name

Andrologia

journal_title

Andrologia

authors

Török L

doi

10.1111/j.1439-0272.1985.tb01048.x

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

497-501

issue

5

eissn

0303-4569

issn

1439-0272

journal_volume

17

pub_type

临床试验,杂志文章
  • Unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol and 5 alpha-androstane-3 beta, 17 beta-diol in normal and pathological human seminal plasma. Comparison with testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate.

    abstract::By means of specific RIA unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol) have been estimated for the first time in normal and pathological human seminal plasma. Testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate (T, D...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Kurniawan E,Tamm J,Volkwein U,Schirren C

    更新日期:1983-03-01 00:00:00

  • Isolation method of Leydig cells from mature male Djungarian hamsters (Phodopus sungorus) and their steroidogenic activity in vitro.

    abstract::For studies addressing the functions of Leydig cells, isolated cells are often better suited than intact animals. Here, the isolation procedure of Leydig cells from adult male Djungarian hamsters (Phodopus sungorus) is described. Cells were isolated using a procedure involving enzymatic dissociation and Percoll-gradie...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Niedziela M,Lerchl A

    更新日期:1999-05-01 00:00:00

  • Azoospermia and Sertoli-cell-only syndrome: hypoxia in the sperm production site due to impairment in venous drainage of male reproductive system.

    abstract::Sertoli-cell-only (SCO) syndrome, or germ cell aplasia, is diagnosed on testicular biopsy when germ cells are seen to be absent without histological impairment of Sertoli or Leydig cells. It is considered a situation of irreversible infertility. Recent studies have shown that varicocele, a bilateral disease, causes hy...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01047.x

    authors: Gat Y,Gornish M,Perlow A,Chakraborty J,Levinger U,Ben-Shlomo I,Pasqualotto F

    更新日期:2010-10-01 00:00:00

  • Non-Robertsonian translocation t (2;11) is associated with infertility in an oligospermic man.

    abstract::Infertility is a major health problem which affects approximately 22% of married couples in reproductive age. Chromosomal defects are the most common genetic abnormalities in infertile men, with an incidence of cytogenetic abnormalities ranging from 2.1% to 15.5%. We describe here the clinical and cytogenetic studies ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12120

    authors: Ananthapur V,Avvari S,Veena K,Sujatha M,Jyothy A

    更新日期:2014-05-01 00:00:00

  • Influence of bacteria and leukocytes on the outcome of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

    abstract::The influence of bacteria and/or leukocytes on the outcome of IVF or ICSI is influenced by three factors which have little in common with in vivo conditions: 1) The process of ejaculate preparation (swim-up, Percoll) with antibiotic buffered media; 2) The small amount of inseminated spermatozoa (100,000 per culture); ...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1998.tb02833.x

    authors: Michelmann HW

    更新日期:1998-01-01 00:00:00

  • Male reproductive health: cause for concern?

    abstract::A substantial body of evidence has accumulated in recent years that human semen quality may be deteriorating. This has been associated with evidence of other changes in male reproductive health, including increases in congenital malformations and testicular cancer in humans, and similar problems in wildlife. Unfortuna...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1046/j.1439-0272.2000.00388.x

    authors: Irvine DS

    更新日期:2000-09-01 00:00:00

  • The efficacy of combined l-carnitine and l-acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis.

    abstract::The purpose of our analysis is to identify the effect of l-carnitine (LC) and l-acetyl carnitine (LAC) on the semen parameters of men with idiopathic oligoasthenoteratozoospermia (iOAT). We performed a comprehensive search to ascertain all the trials about LC and LAC in the treatment of iOAT and compared the results, ...

    journal_title:Andrologia

    pub_type: 杂志文章,meta分析

    doi:10.1111/and.13470

    authors: Zhang X,Cui Y,Dong L,Sun M,Zhang Y

    更新日期:2020-03-01 00:00:00

  • Methylation patterns of methylenetetrahydrofolate reductase gene promoter in infertile males.

    abstract::Errors of folate/homocysteine pathways which are critical for transferring methyl groups have been suggested to affect male fertility. We aimed to evaluate the methylation patterns of the promoter of methylenetetrahydrofolate reductase (MTHFR) gene in infertile males and to investigate the association between MTHFR pr...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13942

    authors: Kulac T,Hekim N,Kocamanoglu F,Beyaz C,Gunes S,Asci R

    更新日期:2020-12-28 00:00:00

  • Aqueous and ethanol extracts of Dracaena arborea (Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats.

    abstract::Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. A...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13381

    authors: Wankeu-Nya M,Watcho P,Deeh Defo PB,Ngadjui E,Nguelefack TB,Kamtchouing P,Kamanyi A

    更新日期:2019-11-01 00:00:00

  • Implications of prostate inflammation on male fertility.

    abstract::The prostate is the seat of three major causes of morbidity: benign prostatic hyperplasia, prostate cancer and prostatitis, three conditions in which inflammation has been implicated. A state of inflammation of the prostate gland, originally incited by an infection, an autoimmune response, a neurogenic stimulus or ano...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13093

    authors: Motrich RD,Salazar FC,Breser ML,Mackern-Oberti JP,Godoy GJ,Olivera C,Paira DA,Rivero VE

    更新日期:2018-12-01 00:00:00

  • Antiapoptotic effects of dehydroepiandrosterone on testicular torsion/detorsion in rats.

    abstract::In the present study, we aimed to evaluate the effects of dehydroepiandrosterone (DHEA) on apoptosis of testicular germ cells after repair of testicular torsion in rats. Twenty-four adult male Sprague-Dawley rats were randomly divided into four groups, with six rats in each group: sham operation, torsion/detorsion (T/...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2008.00806.x

    authors: Yapanoglu T,Aksoy Y,Gursan N,Ozbey I,Ziypak T,Calik M

    更新日期:2008-02-01 00:00:00

  • Screening for bacterial pathogens in semen samples from infertile men with and without leukocytospermia.

    abstract::We aimed to study the correlation between leukocyte counts in semen and bacterial pathogens in seminal samples of infertile men, and to establish the minimum leukocyte count associated with significant bacteriospermia. A total of 116 patients who underwent evaluation of fertility were investigated using routine semen ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2008.00845.x

    authors: Gdoura R,Kchaou W,Znazen A,Chakroun N,Fourati M,Ammar-Keskes L,Hammami A

    更新日期:2008-08-01 00:00:00

  • The effects of 1,2-dibromo-3-chloropropane (DBCP) on general toxicity and gonadotoxicity in rats.

    abstract::This study was set to determine if there is a correlation between the general toxic effect and the gonadotoxic effect of DBCP on male rats. Groups of male rats were injected with a single dose of DBCP (50 mg kg-1) dissolved in dimethylsulfoxide (DMSO). Twenty four hours, one and four weeks post injection animals were ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02581.x

    authors: Kaplanski J,Shemi D,Waksman J,Potashnik G,Sod-Moriah UA

    更新日期:1991-09-01 00:00:00

  • In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat.

    abstract::An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm para...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12082

    authors: Solomon MC,Erasmus N,Henkel RR

    更新日期:2014-05-01 00:00:00

  • Evaluation of the testis function of mice exposed in utero and during lactation to Pfaffia glomerata (Brazilian ginseng).

    abstract::Pfaffia glomerata (Spreng.) Pedersen, popularly known as "Brazilian ginseng," is used as medicinal plant in Brazil to treat inflammatory diseases in general. Previous studies showed that its extract increases the nitric oxide (NO) levels. Knowing that NO downregulates steroidogenesis and that alterations in the action...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13328

    authors: Auharek SA,Carollo CA,Oliveira RJ,Cunha-Laura AL,Monreal ACD,Siqueira JM,Costa DS,de Paiva Condé TR,Wollf DIL,Aloysio Amaral E

    更新日期:2019-09-01 00:00:00

  • Use of microbeads for the detection of binding sites on the human zona pellucida: a scanning electron microscopy (SEM) assay.

    abstract::One prerequisite for fertilization is the specific binding of spermatozoa to the zona pellucida. However, the factors and mechanisms involved in this gamete contact are not well understood. Gamete recognition and binding are species-specific and are controlled by oligosaccharides of the zona and their corresponding ca...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2001.00412.x

    authors: Michelmann HW,Töpfer-Petersen E,Schwartz P,Gratz G,Magerkurth C

    更新日期:2001-09-01 00:00:00

  • Mast cells in testicular biopsies of infertile men with 'mixed atrophy' of seminiferous tubules.

    abstract::Mast cells in the bilateral testicular biopsies of 30 patients with a 'mixed atrophy' of seminiferous tubules were analysed. Seven biopsies from vasectomized patients served as controls. With regard to their characteristic location within testicular tissue, two groups of mast cells could be distinguished, in both cont...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.1999.00287.x

    authors: Jezek D,Banek L,Hittmair A,Pezerović-Panijan R,Goluza T,Schulze W

    更新日期:1999-07-01 00:00:00

  • Dietary omega-3 polyunsaturated fatty acids induce plasminogen activator activity and DNA damage in rabbit spermatozoa.

    abstract::The aim of this study was to determine the effect(s) of dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) on rabbit semen. Adult rabbit bucks were assigned to two groups that were given two diets, a standard diet (control) and a diet supplemented with ω-3 PUFA. Sperm samples were collected from all bucks with the...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12776

    authors: Kokoli AN,Lavrentiadou SN,Zervos IA,Tsantarliotou MP,Georgiadis MP,Nikolaidis EA,Botsoglou N,Boscos CM,Taitzoglou IA

    更新日期:2017-12-01 00:00:00

  • Squalene is a potential endocrine modulator in rat: A proof-of-principle study with 3-methylcholanthrene-induced toxicity.

    abstract::Oestrus urine was proved as a potential endocrine modulator in alleviating the toxicity induced by 3-methylcholanthrene (3-MC) in male rats. We, in this study, aimed to prove the attributing potential of toxicity alleviation to squalene, an oestrus-specific pheromone in rats. A single dose of 3-methylcholanthrene (25 ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13117

    authors: Suriyakalaa U,Ramachandran R,Usha K,Sankarganesh D,Praveenkumar D,Abinaya S,Tirupathi Pichiah PB,Kamalakkannan S,Achiraman S

    更新日期:2018-12-01 00:00:00

  • Enzyme levels in semen of men with different types of azoospermia.

    abstract::The levels of eight enzymes have been measured in the semen of 15 azoospermic subjects. The results indicate that the values of the enzymes Creatine kinase, and Alanine aminotransferase, just as the Aspartate aminotransferase/Alanine aminotransferase ratio are significantly different between excretory and secretory az...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1982.tb03099.x

    authors: Gonzalez Buitrago JM,Garcia Diez LC

    更新日期:1982-01-01 00:00:00

  • Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat.

    abstract::Parameters were obtained from the reproductive organs of ethanol-fed, gossypol-treated Sprague Dawley rats. The experimental animals were fed either on a normal (15.17%) or low protein (8.00%) diet. Measurements included reproductive organ weights, seminal characteristics, serum concentration of testosterone and histo...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1997.tb00317.x

    authors: Akingbemi BT,Rao PV,Aire TA

    更新日期:1997-07-01 00:00:00

  • Parameters predicting sperm retrieval rates during microscopic testicular sperm extraction in nonobstructive azoospermia.

    abstract::The aim of this study was to investigate the predictive value of the parameters that might have an effect on the success of microscopic testicular sperm extraction (micro-TESE) in infertile patients with nonobstructive azoospermia (NOA). Between 2003 and 2014, 860 patients with NOA were retrospectively analysed. The e...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13441

    authors: Kizilkan Y,Toksoz S,Turunc T,Ozkardes H

    更新日期:2019-12-01 00:00:00

  • Kruger strict morphology and post-thaw progressive motility in cryopreserved human spermatozoa.

    abstract::The purpose of this prospective study was to evaluate Kruger strict morphology and conventional semen analysis in predicting cryosurvival and the progressive motility recovery rate of frozen spermatozoa. Our study included 56 semen samples with >10 million spermatozoa per ejaculate. The main outcome measures were conv...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01141.x

    authors: Lee CY,Lee CT,Wu CH,Hsu CS,Hsu MI

    更新日期:2012-05-01 00:00:00

  • Chloroquine excretion in semen following antimalarial-drug administration.

    abstract::The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00782.x

    authors: Adeeko AO,Dada OA

    更新日期:1994-05-01 00:00:00

  • Microcinematographic analysis of the motility of human spermatozoa incubated with caffeine.

    abstract::The effects of incubation with caffeine at final concentration of 0.5 and 5.0 mM for 30 min at ambient temperature were examined in three normal semen samples and three from asthenozoospermic men. A 50 frames/s microcinematographic analysis of the sperm motility was performed and two characteristic parameters of the t...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1982.tb02295.x

    authors: Serres C,Feneux D,David G

    更新日期:1982-09-01 00:00:00

  • Evaluation of various doses of testosterone on accessory reproductive organs and plasma testosterone in intact and gonadectomized rhesus monkeys (Macaca mulatta).

    abstract::The effect of 10 days i.m. treatment of testosterone propionate (TP) on plasma testosterone and accessory reproductive organs were studied in adult (6 to 6 1/2 kg) male rhesus monkeys, housed under natural light conditions using six different dose levels. The study was scheduled in the month of September and October. ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1979.tb02237.x

    authors: Mangat HK

    更新日期:1979-01-01 00:00:00

  • The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.

    abstract::The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb02071.x

    authors: Schulz P,Wolf D,Arbusow V,Bojar H,Klobeck HG,Fittler F

    更新日期:1990-01-01 00:00:00

  • Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice.

    abstract::Pesticides can be toxic to desirable plants and animals, including humans. The aim of this study was to investigate the reproductive effects of low doses of pesticides on male offspring of exposed pregnant mice. Three groups of five female mice were treated daily by oral gavage with dimethoate (5 mg kg(-1) per day), d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01246.x

    authors: Ben Slima A,Ben Abdallah F,Keskes-Ammar L,Mallek Z,El Feki A,Gdoura R

    更新日期:2012-05-01 00:00:00

  • Semen quality in adult male survivors 5 years after the 2008 Wenchuan earthquake.

    abstract::The influence of the Wenchuan earthquake on semen quality of adult male survivors is unclear. We investigated the semen quality included 673 male survivors from the worse-affected counties in the earthquake between Aug 2008 and July 2013. Semen parameters including pH, volume, concentration, motility and morphology we...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12573

    authors: Chen XM,Chen SM,Yue HX,Lin L,Wu YB,Liu B,Jiang M,Ma YX

    更新日期:2016-12-01 00:00:00

  • Mutational effect of human CFAP43 splice-site variant causing multiple morphological abnormalities of the sperm flagella.

    abstract::Multiple morphological abnormalities of the sperm flagella (MMAF) is a rare disease associated with male infertility. In our previous study, we identified a homozygous CFAP43 splice-site variant, c.3661-2delA, in a patient with MMAF. However, the mutational effect of this variant was unknown. Here, using a minigene as...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13575

    authors: Li L,Feng F,Wang Y,Guo J,Yue W

    更新日期:2020-07-01 00:00:00