Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease.

abstract：:GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl-] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models. However, the tem...

journal_title：Scientific reports

authors： Chen L,Wan L,Wu Z,Ren W,Huang Y,Qian B,Wang Y

更新日期：2017-03-13 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1...

journal_title：Scientific reports

authors： Bulluck H,Bryant JA,Lim MX,Tan XW,Ramlall M,Francis R,Kotecha T,Cabrera-Fuentes HA,Knight DS,Fontana M,Moon JC,Hausenloy DJ

更新日期：2017-07-07 00:00:00

abstract：:The same prebiotics have produced inconsistent effects on microbiota when evaluated in different batch fermentation studies. To understand the reasons behind these discrepancies, we compared impact of one prebiotic formula on the same inoculated fecal microbiota in two frequently used batch systems: phosphate-buffered...

journal_title：Scientific reports

authors： Long W,Xue Z,Zhang Q,Feng Z,Bridgewater L,Wang L,Zhao L,Pang X

更新日期：2015-08-25 00:00:00

abstract：:Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current ...

journal_title：Scientific reports

authors： Huang J,Huang K,Xu R,Wang M,Liao Q,Xiong H,Li C,Tang X,Shan Z,Zhang M,Rong X,Nelson K,Fu Y

更新日期：2016-08-11 00:00:00

abstract：:The present study investigates the biostimulant effects of 18 Crude Bio-Extracts (CBEs) obtained from Microalgae and Cyanobacteria on tomato plant growth, chlorophyll content, nutrient uptake and metabolite profile. Significant root and shoot length improvement (112.65%, 53.70%); was recorded at treatment with Aphanot...

journal_title：Scientific reports

authors： Mutale-Joan C,Redouane B,Najib E,Yassine K,Lyamlouli K,Laila S,Zeroual Y,Hicham EA

更新日期：2020-02-18 00:00:00

abstract：:We investigated in this paper a novel bilayer composite obtained by sol-gel and spin coating of the ferroelectric 0.92Na0.5Bi0.5TiO3-0.08BaTiO3 (abbreviated as BNT-BT0.08) and ferromagnetic CoFe2O4 phases, for miniature low-frequency magnetic sensors and piezoelectric sensors. This heterostructure, deposited on Si-Pt ...

journal_title：Scientific reports

authors： Cernea M,Vasile BS,Surdu VA,Trusca R,Bartha C,Craciun F,Galassi C

更新日期：2018-12-14 00:00:00

abstract：:Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that fully describe the spat...

journal_title：Scientific reports

authors： Denker M,Zehl L,Kilavik BE,Diesmann M,Brochier T,Riehle A,Grün S

更新日期：2018-03-26 00:00:00

abstract：:Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...

journal_title：Scientific reports

authors： Shi K,Liu L,He YJ,Li D,Yuan LX,Lash GE,Li L

更新日期：2016-11-30 00:00:00

abstract：:The detection and characterization of highly enriched uranium (HEU) presents a large challenge in the non-proliferation field. HEU has a low neutron emission rate and most gamma rays are low energy and easily shielded. To address this challenge, an instrument known as the dual-particle imager (DPI) was used with a por...

journal_title：Scientific reports

authors： Hamel MC,Polack JK,Ruch ML,Marcath MJ,Clarke SD,Pozzi SA

更新日期：2017-08-11 00:00:00

abstract：:Riverine and atmospheric inputs are often considered as the main terrestrial sources of dissolved inorganic nitrogen (DIN), phosphorus (DIP), and silicon (DSi) in the ocean. However, the fluxes of nutrients via submarine groundwater discharge (SGD) often exceed riverine inputs in different local and regional scale set...

journal_title：Scientific reports

authors： Cho HM,Kim G,Kwon EY,Moosdorf N,Garcia-Orellana J,Santos IR

更新日期：2018-02-05 00:00:00

abstract：:Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...

journal_title：Scientific reports

authors： Stevens E,Laabei M,Gardner S,Somerville GA,Massey RC

更新日期：2017-10-23 00:00:00

abstract：:The General Unified Threshold model for Survival (GUTS) integrates previously published toxicokinetic-toxicodynamic models and estimates survival with explicitly defined assumptions. Importantly, GUTS accounts for time-variable exposure to the stressor. We performed three studies to test the ability of GUTS to predict...

journal_title：Scientific reports

authors： Ashauer R,Albert C,Augustine S,Cedergreen N,Charles S,Ducrot V,Focks A,Gabsi F,Gergs A,Goussen B,Jager T,Kramer NI,Nyman AM,Poulsen V,Reichenberger S,Schäfer RB,Van den Brink PJ,Veltman K,Vogel S,Zimmer EI,Preuss

更新日期：2016-07-06 00:00:00

abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

journal_title：Scientific reports

authors： Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

更新日期：2017-06-16 00:00:00

abstract：:Most large carnivore populations currently occur in heterogeneous landscapes, with source populations embedded in a matrix of human-dominated habitats. Understanding changes in distribution of endangered carnivores is critical for prioritizing and implementing conservation strategies. We examined distribution and dyna...

journal_title：Scientific reports

authors： Srivathsa A,Karanth KU,Kumar NS,Oli MK

更新日期：2019-02-28 00:00:00

abstract：:Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry into the CNS of hamsters. NiV initially predominantly targeted the olfactory epithelium in the nasal turbinat...

journal_title：Scientific reports

authors： Munster VJ,Prescott JB,Bushmaker T,Long D,Rosenke R,Thomas T,Scott D,Fischer ER,Feldmann H,de Wit E

更新日期：2012-01-01 00:00:00

abstract：:Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is particularly sensitive to early-life influences, and plays a pivotal role in programming the conceptus. We examine the influence of suboptimal gr...

journal_title：Scientific reports

authors： Aiken CE,Tarry-Adkins JL,Ozanne SE

更新日期：2015-11-03 00:00:00

abstract：:Amino acid biosynthesis pathways observed in nature typically require enzymes that are made with the amino acids they produce. For example, Escherichia coli produces cysteine from serine via two enzymes that contain cysteine: serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). To solve this c...

journal_title：Scientific reports

authors： Fujishima K,Wang KM,Palmer JA,Abe N,Nakahigashi K,Endy D,Rothschild LJ

更新日期：2018-01-29 00:00:00

abstract：:Guanine-rich quadruplex (G-QD) are formed by conversion of nucleotides with specific sequences by stabilization of positively charged K+ or Na+. These G-QD structures differentially absorb two-directional (right- and left-handed) circularly polarized light, which can discriminate the parallel or anti-parallel structur...

journal_title：Scientific reports

authors： Kim R,Youn YS,Kang M,Kim E

更新日期：2020-11-24 00:00:00

abstract：:Geographic variation in aridity determines environmental productivity patterns, including large-scale variability in pathogens, vectors and associated diseases. If disease risk decreases with increasing aridity and is matched by immune defense, we predict a decrease in innate immune function along a gradient of increa...

journal_title：Scientific reports

authors： Nwaogu CJ,Cresswell W,Tieleman BI

更新日期：2020-04-03 00:00:00

abstract：:The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...

journal_title：Scientific reports

authors： Aubanel V,Schwartz JL

更新日期：2020-11-11 00:00:00

abstract：:Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...

journal_title：Scientific reports

authors： Subedi NR,Jung PS,Bredeweg EL,Nemati S,Baker SE,Christodoulides DN,Vasdekis AE

更新日期：2020-11-19 00:00:00

abstract：:Evidence on the association between dietary fiber intake and pancreatic cancer risk has been controversial. Therefore, we carried out this meta-analysis to summarize available evidence from epidemiologic studies on this point. Relevant studies were identified by searching PubMed, Embase and Web of Science databases as...

journal_title：Scientific reports

authors： Wang CH,Qiao C,Wang RC,Zhou WP

更新日期：2015-06-02 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Lebreton L,Egger M,Slat B

更新日期：2020-01-30 00:00:00

abstract：:Behavioral addiction (BA) is characterized by repeated, impulsive and compulsive seeking of specific behaviors, even with consequent negative outcomes. In drug addiction, alterations in biological mechanisms, such as monoamines and epigenetic processes, have been suggested, whereas whether such mechanisms are also alt...

journal_title：Scientific reports

authors： Asaoka Y,Won M,Morita T,Ishikawa E,Lee YA,Goto Y

更新日期：2020-07-16 00:00:00

abstract：:Non-Markovianity has recently attracted large interest due to significant advances in its characterization and its exploitation for quantum information processing. However, up to now, only non-Markovian regimes featuring environment to system backflow of information (strong non-Markovianity) have been experimentally s...

journal_title：Scientific reports

authors： Bernardes NK,Cuevas A,Orieux A,Monken CH,Mataloni P,Sciarrino F,Santos MF

更新日期：2015-12-02 00:00:00

abstract：:Global exponential increase in levels of Photovoltaic (PV) module waste is an increasing concern. The purpose of this study is to investigate if there is energy value in the polymers contained within first-generation crystalline silicon (c-Si) PV modules to help contribute positively to recycling rates and the circula...

journal_title：Scientific reports

authors： Farrell C,Osman AI,Zhang X,Murphy A,Doherty R,Morgan K,Rooney DW,Harrison J,Coulter R,Shen D

更新日期：2019-03-27 00:00:00

abstract：:Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarke...

journal_title：Scientific reports

authors： Kuiper JJ,Beretta L,Nierkens S,van Leeuwen R,Ten Dam-van Loon NH,Ossewaarde-van Norel J,Bartels MC,de Groot-Mijnes JD,Schellekens P,de Boer JH,Radstake TR

更新日期：2017-01-27 00:00:00

abstract：:To appraise the content and pollution level of cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni) and lead (Pb) in bus stop dusts, representative samples (n = 53) were collected from the city of Qingyang in Gansu province, NW China. The Cd, As, Hg, Ni, and Pb contents and physicochemical properties (particle size, ...

journal_title：Scientific reports

authors： Wu Y,Lu X

更新日期：2018-08-22 00:00:00

abstract：:Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...

journal_title：Scientific reports

authors： Yao J,Yuan Y,Zheng F,Zhan CG

更新日期：2016-02-29 00:00:00