Detection and variability analyses of CRISPR-like loci in the H. pylori genome.

Abstract:

:Helicobacter pylori is a human pathogenic bacterium with a high genomic plasticity. Although the functional CRISPR-Cas system has not been found in its genome, CRISPR-like loci have been recently identified. In this work, 53 genomes from different geographical areas are analyzed for the search and analysis of variability of this type of structure. We confirm the presence of a locus that was previously described in the VlpC gene in al lgenomes, and we characterize new CRISPR-like loci in other genomic locations. By studying the variability and gene location of these loci, the evolution and the possible roles of these sequences are discussed. Additionally, the usefulness of this type of sequences as a phylogenetic marker has been demonstrated, associating the different strains by geographical area.

journal_name

PeerJ

journal_title

PeerJ

authors

García-Zea JA,de la Herrán R,Robles Rodríguez F,Navajas-Pérez R,Ruiz Rejón C

doi

10.7717/peerj.6221

subject

Has Abstract

pub_date

2019-01-11 00:00:00

pages

e6221

issn

2167-8359

pii

6221

journal_volume

7

pub_type

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