A nomogram for individual prediction of vascular invasion in primary breast cancer.


OBJECTIVES:To explore the feasibility of preoperative prediction of vascular invasion (VI) in breast cancer patients using nomogram based on multiparametric MRI and pathological reports. METHODS:We retrospectively collected 200 patients with confirmed breast cancer between January 2016 and January 2018. All patients underwent MRI examinations before the surgery. VI was identified by postoperative pathology. The 200 patients were randomly divided into training (n = 100) and validation datasets (n = 100) at a ratio of 1:1. Least absolute shrinkage and selection operator (LASSO) regression was used to select predictors most associated with VI of breast cancer. A nomogram was constructed to calculate the area under the curve (AUC) of receiver operating characteristics, sensitivity, specificity, accuracy, positive prediction value (PPV) and negative prediction value (NPV). We bootstrapped the data for 2000 times without setting the random seed to obtain corrected results. RESULTS:VI was observed in 79 patients (39.5%). LASSO selected 10 predictors associated with VI. In the training dataset, the AUC for nomogram was 0.94 (95% confidence interval [CI]: 0.89-0.99, the sensitivity was 78.9% (95%CI: 72.4%-89.1%), the specificity was 95.3% (95%CI: 89.1%-100.0%), the accuracy was 86.0% (95%CI: 82.0%-92.0%), the PPV was 95.7% (95%CI: 90.0%-100.0%), and the NPV was 77.4% (95%CI: 67.8%-87.0%). In the validation dataset, the AUC for nomogram was 0.89 (95%CI: 0.83-0.95), the sensitivity was 70.3% (95%CI: 60.7%-79.2%), the specificity was 88.9% (95%CI: 80.0%-97.1%), the accuracy was 77.0% (95%CI: 70.0%-83.0%), the PPV was 91.8% (95%CI: 85.3%-98.0%), and the NPV was 62.7% (95%CI: 51.7%-74.0%). The nomogram calibration curve shows good agreement between the predicted probability and the actual probability. CONCLUSION:The proposed nomogram could be used to predict VI in breast cancer patients, which was helpful for clinical decision-making.


Eur J Radiol


Ouyang FS,Guo BL,Huang XY,Ouyang LZ,Zhou CR,Zhang R,Wu ML,Yang ZS,Wu SK,Guo TD,Yang SM,Hu QG




Has Abstract


2019-01-01 00:00:00












  • CT and MR imaging of the normal and pathologic conditions of the facial nerve.

    abstract::Computed tomography (CT) and magnetic resonance imaging (MRI) are well established imaging modalities to examine the facial nerve as well as the course of the facial nerve itself. High spatial resolution is guaranteed not only in the x- and y-axis, but also in the z-axis using multislice spiral CT. With this technique...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Jäger L,Reiser M

    更新日期:2001-11-01 00:00:00

  • Image-guided tumor ablation for the treatment of recurrent non-small cell lung cancer within the radiation field.

    abstract:PURPOSE:The treatment options for non-small-cell lung cancer (NSCLC) that recurs after irradiation are limited. Image-guided percutaneous thermal ablation is an effective option in treating NSCLC that may provide an alternative to reirradiation. The purpose of this paper is to determine the survival and palliative bene...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Leung VA,DiPetrillo TA,Dupuy DE

    更新日期:2011-12-01 00:00:00

  • The effective and collective dose to patients undergoing abdominopelvic and trunk computed tomography examinations: A Belgian multicentre study.

    abstract:OBJECTIVES:This study aims to evaluate the radiation exposure to patients undergoing an abdominopelvic or a chest and abdominopelvic (trunk) CT examination and to assess compliance to imaging referral guidelines. METHODS:To this end, 357 standard abdominopelvic and trunk CT scans were collected from 8 Belgian institut...

    journal_title:European journal of radiology

    pub_type: 杂志文章,多中心研究


    authors: De Roo B,Stichelbaut N,Hoste P,Verstraete K,Bacher K

    更新日期:2019-02-01 00:00:00

  • Superb microvascular imaging for the detection of parenchymal perfusion in normal and undescended testes in young children.

    abstract:OBJECTIVES:To compare the detectability of perfusion difference between normal and undescended testes (UDT) in young children using conventional Power Doppler Imaging (PDI) and Superb Microvascular Imaging (SMI). METHODS:We prospectively performed testicular ultrasonography including PDI and SMI for the evaluation of ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Lee YS,Kim MJ,Han SW,Lee HS,Im YJ,Shin HJ,Lee MJ

    更新日期:2016-03-01 00:00:00

  • The use of coronary stent in hepatic artery stenosis after orthotopic liver transplantation.

    abstract:PURPOSE:This retrospective study was undertaken to evaluate the effectiveness of coronary stent placement in hepatic artery stenosis after orthotopic liver transplantation (OLT). MATERIALS AND METHODS:Of 430 consecutive adult orthotopic liver transplant recipients between November 2003 and September 2005, 17 had hepat...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Huang M,Shan H,Jiang Z,Li Z,Zhu K,Guan S,Qian J,Chen G,Lu M,Yang Y

    更新日期:2006-12-01 00:00:00

  • PET-CT offers accurate assessment of tumour length in oesophageal malignancy.

    abstract:INTRODUCTION:Radiotherapy is increasingly used for both curative and palliative treatment of oesophageal malignancy. Accurate treatment depends on determining tumour location and length. This study assessed the value of PET-CT versus other staging modalities in determining tumour length. MATERIALS AND METHODS:Oesophag...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Rollins KE,Lucas E,Tewari N,James E,Hughes S,Catton JA

    更新日期:2015-02-01 00:00:00

  • Computed tomography in maple syrup urine disease.

    abstract::Maple Syrup Urine Disease (MSUD) is an inherited metabolic disorder characterized by a severe, usually lethal, neonatal course in the early stages with pseudotumor cerebri and pathologically documented increased cerebral water content. CT and MRI studies in MSUD are few and the data are overlapping. This study reports...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Taccone A,Schiaffino MC,Cerone R,Fondelli MP,Romano C

    更新日期:1992-05-01 00:00:00

  • Reducing CT radiation exposure with organ effective modulation: A retrospective clinical study.

    abstract:OBJECTIVE:To evaluate the effect of Organ Effective Modulation (OEM) on objective and subjective image quality as well as the radiation dose needed for thoracoabdominal computed tomography (CT). METHOD:This retrospective study included 196 consecutive patients who were referred to our institution for enhanced thoracoa...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Akai H,Kiryu S,Shibata E,Maeda E,Sato J,Tomizawa N,Nojima M,Ohtomo K

    更新日期:2016-09-01 00:00:00

  • Quantitative synthetic MRI for evaluation of the lumbar intervertebral disk degeneration in patients with chronic low back pain.

    abstract:PURPOSE:To verify the feasibility of synthetic MRI in quantitative evaluation of lumbar intervertebral disk (IVD) degeneration, as compared to the conventional CarrPurcell-Meiboom-Gill (CPMG) T2 mapping approach. METHODS:Twenty-four patients with chronic low back pain participated in this study. Patients underwent rou...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Jiang Y,Yu L,Luo X,Lin Y,He B,Wu B,Qu J,Wu T,Pu-Yeh W,Zhang C,Li C,Chen M

    更新日期:2020-03-01 00:00:00

  • Measurement of single kidney contrast media clearance by multiphasic spiral computed tomography: preliminary results.

    abstract:OBJECTIVE:We present preliminary results of a new method (hereinafter called 'CT-clearance') to measure single kidney contrast media clearance by performing multiphasic helical CT of the kidneys. CT-clearance was calculated according to an extension of the Patlak-Plot. In contrast to prior investigators, who repeatedly...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Hackstein N,Puille MF,Bak BH,Scharwat O,Rau WS

    更新日期:2001-09-01 00:00:00

  • Assessment of anemia during CT pulmonary angiography.

    abstract:OBJECTIVES:Anemia is associated with increased mortality in patients with acute symptomatic pulmonary embolism (PE). The purpose of this study was to evaluate the feasibility of Hounsfield unit (HU) measurements on the single unenhanced trigger slice of pulmonary CT angiography scans for diagnosis of anemia. MATERIAL ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Jung C,Groth M,Bley TA,Henes FO,Treszl A,Adam G,Bannas P

    更新日期:2012-12-01 00:00:00

  • Convolutional neural network-automated hepatobiliary phase adequacy evaluation may optimize examination time.

    abstract:PURPOSE:To develop and evaluate the performance of a fully-automated convolutional neural network (CNN)-based algorithm to evaluate hepatobiliary phase (HBP) adequacy of gadoxetate disodium (EOB)-enhanced MRI. Secondarily, we explored the potential of the proposed CNN algorithm to reduce examination length by applying ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Cunha GM,Hasenstab KA,Higaki A,Wang K,Delgado T,Brunsing RL,Schlein A,Schwartzman A,Hsiao A,Sirlin CB,Fowler KJ

    更新日期:2020-03-01 00:00:00

  • Diagnosing acute pancreatitis-Clinical and radiological characterisation of patients without threefold increase of serum lipase.

    abstract:OBJECTIVES:Diagnosing acute pancreatitis (AP) may be challenging in patients with acute abdominal pain but missing threefold increased serum lipase levels (Lip-). This studyaims both to characterize these patients using clinical, radiological and mortality data, and to assess the group of patients who need contrast-enh...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Avanesov M,Löser A,Keller S,Weinrich JM,Laqmani A,Adam G,Karul M,Yamamura J

    更新日期:2017-10-01 00:00:00

  • Value of conventional chest radiography for the detection of coronary calcifications: comparison with MSCT.

    abstract:PURPOSE:To evaluate if computed tomography (CT) coronary calcium scoring is needed after detection of coronary calcifications on conventional chest radiographs. MATERIALS AND METHODS:One hundred and five patients (67 men; 57.2+/-12.8 years) with suspected coronary artery disease underwent conventional chest radiograph...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Mahnken AH,Wein BB,Sinha AM,Günther RW,Wildberger JE

    更新日期:2009-03-01 00:00:00

  • Improving the prediction of lung adenocarcinoma invasive component on CT: Value of a vessel removal algorithm during software segmentation of subsolid nodules.

    abstract:PURPOSE:To evaluate the value of a vessel removal algorithm in segmentation of subsolid nodules by comparing the software solid component measurement on CT, before and after vessel removal, with the measurement of the invasive component on pathology in lung adenocarcinomas manifesting as subsolid nodules. MATERIALS AN...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Garzelli L,Goo JM,Ahn SY,Chae KJ,Park CM,Jung J,Hong H

    更新日期:2018-03-01 00:00:00

  • Smartphones, tablets and mobile applications for radiology.

    abstract:BACKGROUND:Smartphones are phone devices that may also be used for browsing, navigation and running smaller computer programs called applications. One may consider them as compact personal computers which are primarily to be used for making phone calls. Tablets or "tablet PCs" are fully functioning standalone computers...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Székely A,Talanow R,Bágyi P

    更新日期:2013-05-01 00:00:00

  • Prediction of molecular subtypes of breast cancer using BI-RADS features based on a "white box" machine learning approach in a multi-modal imaging setting.

    abstract:PURPOSE:To develop and validate an interpretable and repeatable machine learning model approach to predict molecular subtypes of breast cancer from clinical metainformation together with mammography and MRI images. METHODS:We retrospectively assessed 363 breast cancer cases (Luminal A 151, Luminal B 96, HER2 76, and B...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Wu M,Zhong X,Peng Q,Xu M,Huang S,Yuan J,Ma J,Tan T

    更新日期:2019-05-01 00:00:00

  • Detection of lung cancer on the chest radiograph: a study on observer performance.

    abstract:STUDY OBJECTIVES:to study the validity and observers consistency in the detection of lung cancer on the chest radiograph. MATERIALS AND METHODS:the chest radiographs of 100 clinical cases were interpreted by 14 observers. The radiographs were obtained from 30 patients with initially missed but histopathologically prov...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Quekel LG,Kessels AG,Goei R,van Engelshoven JM

    更新日期:2001-08-01 00:00:00

  • Imaging of tendons--adaptation, degeneration, rupture.

    abstract::Tendon imaging is mainly performed with ultrasonography (US) and magnetic resonance imaging (MRI) and has been improved within the last years because of technical advancements and a better understanding of tendon pathology. Several concepts concerning the etiology and the course of tendon diseases have influenced imag...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Kainberger F,Mittermaier F,Seidl G,Parth E,Weinstabl R

    更新日期:1997-11-01 00:00:00

  • High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores.

    abstract:OBJECTIVE:To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. METHODS:HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Demirkazik FB,Ariyürek OM,Ozçelik U,Göçmen A,Hassanabad HK,Kiper N

    更新日期:2001-01-01 00:00:00

  • Pulmonary involvement in angio-immunoblastic lymphadenopathy (A.I.L.D.). Case report and review of literature.

    abstract::A.I.L.D. is a hyperimmune disorder of the B-cell system of unknown etiology. Although it is distinguished morphologically from Hodgkin's disease, the clinical manifestations may be similar. Pulmonary localisation of A.I.L.D. is infrequently seen. We report the radiologic and pathologic findings of a pulmonary localisa...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Kuijpers TJ,Shaw MP,Croonen AM

    更新日期:1983-05-01 00:00:00

  • Baseline screening mammography with one versus two views.

    abstract::Two-view baseline screening mammograms (oblique and cranial views) of 303 women recalled for further studies from among 7,245 women screened were reviewed by four experienced radiologists separately to evaluate the importance of the number of views taken for screening. As compared with the oblique view only, two views...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Anttinen I,Pamilo M,Roiha M,Soiva M,Suramo I

    更新日期:1989-11-01 00:00:00

  • F-18 FDG PET-CT in patients with recurrent glioma: comparison with contrast enhanced MRI.

    abstract:PURPOSE:The purpose of the study was to compare the efficacies of FDG PET-CT and contrast enhanced MRI in detection of recurrent gliomas. METHODS:Ninety histopathologically proven glioma patients with clinical suspicion of recurrence were evaluated. All patients underwent FDG PET-CT scan and contrast enhanced MRI. Com...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Santra A,Kumar R,Sharma P,Bal C,Kumar A,Julka PK,Malhotra A

    更新日期:2012-03-01 00:00:00

  • Selective archiving of radiologic images.

    abstract::The increasing number of radiographic images is a problem in most radiology departments. The problem will be emphasized with the introduction of digital acquisition and storage of radiographs. Changes in image management strategies will therefore become necessary. Such strategies will have great technologic and financ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Geijer M,Altmann P,Sigstedt B,Schlossman D

    更新日期:1992-05-01 00:00:00

  • Imaging of spontaneous intracerebral hemorrhages by means of transcranial color-coded sonography.

    abstract:BACKGROUND:Transcranial color-coded sonography (TCCS) allows the visualization of cerebral structures and enables monitoring of circulatory disorders occurring within the circle of Willis. OBJECTIVE:To verify whether TCCS is a reliable method in imaging intracerebral hemorrhages (ICHs) and to what degree its results a...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Kukulska-Pawluczuk B,Książkiewicz B,Nowaczewska M

    更新日期:2012-06-01 00:00:00

  • Peripheral DSA with automated stepping.

    abstract::Peripheral digital angiography can be applied with automated stepping and in digital subtracted technique to evaluate the complete lower extremities angiographically with one single injection of contrast medium. Altogether 25 DSA-examinations were compared with non-substracted technique. By DSA-technique additional se...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Fink U,Heywang SH,Hilbertz T,Fischer K,Jenner E,Buchsteiner W

    更新日期:1991-07-01 00:00:00

  • Use of rapid prototyping and three-dimensional reconstruction modeling in the management of complex fractures.

    abstract:BACKGROUND:The production of a copy of the fracture or a deformity in a bone with a complex geometry can be one of the important applications of the integration between two modern computer-based technologies, reverse engineering (RE) and rapid prototyping (RP). METHODS:This article reviews recent development in this f...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Bagaria V,Deshpande S,Rasalkar DD,Kuthe A,Paunipagar BK

    更新日期:2011-12-01 00:00:00

  • Optimal sequence timing of CT angiography and perfusion CT in patients with stroke.

    abstract:OBJECTIVE:Standard stroke CT protocols start with non-enhanced CT followed by perfusion-CT (PCT) and end with CTA. We aimed to evaluate the influence of the sequence of PCT and CTA on quantitative perfusion parameters, venous contrast enhancement and examination time to save critical time in the therapeutic window in s...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Morhard D,Wirth CD,Reiser MF,Schulte-Altedorneburg G,Ertl-Wagner B

    更新日期:2013-06-01 00:00:00

  • Radiation dose of CT coronary angiography in clinical practice: objective evaluation of strategies for dose optimization.

    abstract:BACKGROUND:CT coronary angiography (CTCA) is an evolving modality for the diagnosis of coronary artery disease. Radiation burden associated with CTCA has been a major concern in the wider application of this technique. It is important to reduce the radiation dose without compromising the image quality. OBJECTIVES:To e...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Yerramasu A,Venuraju S,Atwal S,Goodman D,Lipkin D,Lahiri A

    更新日期:2012-07-01 00:00:00

  • Peri-aortic fluid after surgery on the ascending aorta: Worrisome indicator of complications or innocent postoperative finding?

    abstract:OBJECTIVE:The Bentall procedure is associated with several complications often accompanied by accumulation of fluid around the aortic graft. CT is the imaging modality of choice to detect these complications. Since these early complications are, however, not easily distinguished from physiological postoperative changes...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Boccalini S,Swart LE,Bekkers JA,Nieman K,Krestin GP,Bogers AJJC,Budde RPJ

    更新日期:2017-10-01 00:00:00