Abstract：
OBJECTIVE:The objective of this study was to establish the cut-off value of the signal intensity drop on chemical shift magnetic resonance imaging (MRI) with appropriate sensitivity and specificity to differentiate osteoporotic from neoplastic wedging of the spine. PATIENTS AND METHODS:All patients with wedging of vertebral bodies were included consecutively between February 2006 and January 2007. A chemical shift MRI was performed and signal intensity after (in-phase and out-phase) images were obtained. A DXA was performed in all. RESULTS:A total of 40 patients were included, 20 with osteoporotic wedging (group 1) and 20 neoplastic (group 2). They were 21 males and 19 females. Acute vertebral collapse was observed in 15 patients in group 1 and subacute collapse in another 5 patients, while in group 2, 11 patients showed acute collapse and 9 patients (45%) showed subacute vertebral collapse. On the chemical shift MRI a substantial reduction in signal intensity was found in all lesions in both groups. The proportional changes observed in signal intensity of bone marrow lesions on in-phase compared with out-of-phase images showed significant differences in both groups (P<0.05). At a cut-off value of 35%, the observed sensitivity of out-of-phase images was 95%, specificity was 100%, positive predictive value was 100% and negative predictive value was 95.2%. CONCLUSION:A chemical shift MRI is useful in order to differentiate patients with vertebral collapse due to underlying osteoporosis or neoplastic process.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Ragab Y,Emad Y,Gheita T,Mansour M,Abou-Zeid A,Ferrari S,Rasker JJdoi
10.1016/j.ejrad.2008.06.019subject
Has Abstractpub_date
2009-10-01 00:00:00pages
125-33issue
1eissn
0720-048Xissn
1872-7727pii
S0720-048X(08)00351-3journal_volume
72pub_type
杂志文章abstract：BACKGROUND AND PURPOSE:Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (...
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pub_type： 临床试验,杂志文章
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journal_title：European journal of radiology
pub_type： 杂志文章,多中心研究
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journal_title：European journal of radiology
pub_type： 杂志文章,评审
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：European journal of radiology
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journal_title：European journal of radiology
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：European journal of radiology
pub_type： 杂志文章
doi：10.1016/0720-048x(94)90334-4
更新日期：1994-08-01 00:00:00
