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Pulmonary infections following bone marrow transplantation: high-resolution CT findings in 35 paediatric patients.

Abstract：

PURPOSE:The purpose of this study was to assess the high-resolution CT findings of paediatric patients who had pulmonary infections following bone marrow transplantation (BMT), and to evaluate the differential diagnosis through high-resolution CT of the various pathogens responsible for pulmonary infections after BMT. PATIENTS AND METHODS:The study included 35 consecutive patients who had documented pulmonary infection, high-resolution CT of the chest performed within 24h of the beginning of symptoms, and proven diagnosis within 1 week of the onset of symptoms. The pulmonary infections were due to viruses (n=16), bacteria (n=9), fungi (n=9), and protozoa (n=1). Two radiologists analyzed the CT scans and reached final decisions regarding the findings by consensus. RESULTS:Four patients with confirmed pneumonia had normal high-resolution CT scans. Regarding the viral infections, the most frequent features were areas of ground-glass attenuation (43.7%) and small centrilobular nodules (31.2%). Airspace consolidation (88.9%), small centrilobular nodules (22.2%) and ground-glass attenuation (22.2%) were the most frequent findings in patients with bacterial pneumonia following BMT. Large nodules were seen in 66.7% of the patients with fungal pneumonia, and in only one case of virus infection. The "halo sign" (n=5) was seen only in patients with fungal pneumonia. CONCLUSION:In conclusion, the main causes of pulmonary infection in paediatric patients following BMT share similar high-resolution CT findings. Large nodules and "halo sign" are more common in patients with fungal infections.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Gasparetto TD,Escuissato DL,Marchiori E

doi

10.1016/j.ejrad.2007.05.021

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

117-21

issue

1

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(07)00265-3

journal_volume

66

pub_type

杂志文章

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