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Lower follicular n-3 polyunsaturated fatty acid levels are associated with a better response to ovarian stimulation.

Abstract：

OBJECTIVES:To analyze in detail the fatty acid (FA) composition of follicular fluid (FF) from two-sized follicles at oocyte retrieval and to determine associations of the FAs from large follicles with the woman's age and the response to ovarian stimulation. DESIGN:Observational study. SETTING:University and fertility clinic. PATIENTS:Sixty-four women (age 19-46), consisting of unfertile patients and oocyte donors, undergoing controlled ovarian stimulation. INTERVENTIONS:None. MAIN OUTCOME MEASURE(S):FF from small (< 12 mm) and large (≥ 18 mm) follicles was collected at oocyte retrieval. FAs by gas chromatography-flame ionization detection. RESULT:Thirty-two FAs with chain lengths ranging from 14 to 25 carbons were identified. There was a readjustment in FA distribution as follicle size increased, raising very long-chain saturated FAs, nervonic (24:1n-9), arachidonic (20:4n-6), and n-3 polyunsaturated FAs (PUFA, P < 0.001), the latter mainly due to an increase in docosahexaenoic acid (22:6n-3, DHA). In large follicles, double bond and peroxidizability indices and total n-3 PUFA, particularly DHA, correlated positively with the woman's age and negatively with the number of total and mature oocytes, total and top-quality embryos, and fertilization rate. CONCLUSIONS:We have described 32 FAs in ovarian FF, of which 16 changed their distribution with follicle size. The results also indicate that lower n-3 PUFA levels in large follicles, which are associated with younger women, predict a better response to ovarian stimulation based on the recovery of total and mature oocytes, total and top-quality embryos, and fertilization rate per cycle. KEY MESSAGE:The fatty acid profile of ovarian FF changes as the follicle grows and lower n-3 PUFA levels in large follicles, associated with younger women, predict a better response to ovarian stimulation.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Ruiz-Sanz JI,Pérez-Ruiz I,Meijide S,Ferrando M,Larreategui Z,Ruiz-Larrea MB

doi

10.1007/s10815-018-1384-1

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

473-482

issue

eissn

1058-0468

issn

1573-7330

pii

10.1007/s10815-018-1384-1

journal_volume

pub_type

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Lower follicular n-3 polyunsaturated fatty acid levels are associated with a better response to ovarian stimulation.