Human immunodeficiency virus-related cerebral white matter disease in children.

Abstract:

:The human immunodeficiency virus (HIV) epidemic seems largely controlled by anti-retroviral treatment with resultant large numbers of children growing up with the disease on long-term treatment, placing them at higher risk to develop HIV-related brain injury, ongoing cognitive impairment and treatment-related neurological complications. Cerebral white matter involvement is a common radiologic finding in HIV infection and the causes of this have overlapping appearances, ranging from diffuse widespread involvement to focal lesions. The varied pathophysiology is broadly grouped into primary effects of HIV, opportunistic infection, vascular disease and neoplasms. White matter changes in children can be different from those in adults. This review provides guidance to radiologists with the diagnostic dilemma of nonspecific cerebral white matter lesions in children with HIV. The authors discuss common causes of HIV-related cerebral white matter disease as well as the role of neuroimaging in the management of these children.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Ackermann C,van Toorn R,Andronikou S

doi

10.1007/s00247-018-4310-x

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

652-662

issue

5

eissn

0301-0449

issn

1432-1998

pii

10.1007/s00247-018-4310-x

journal_volume

49

pub_type

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