Abstract:
Purpose:Refractory or recurrent vitreous seeds account for a large proportion of failure of eye salvage in retinoblastoma. The purpose of this study is to evaluate the efficacy of periocular topotecan (POT) in the management of vitreous seeds in retinoblastoma. Methods:Retrospective, interventional study of patients with retinoblastoma with vitreous seeds who received POT concurrent with intravenous chemotherapy (IVC). Results:Thirty-eight eyes of 35 patients received POT. Five eyes (13%) belonged to International Classification of Retinoblastoma group C, 23 eyes (61%) belonged to group D, and 10 eyes (26%) belonged to group E. Primary treatment included IVC with a combination of carboplatin, etoposide, and vincristine for a mean of 6 cycles (median 6; range 6-9). Concurrent to IVC from the fourth cycle onward, all patients received POT. Focal vitreous seeds were present in 20 eyes (53%) which received a mean of 3 injections (median 3; range 1-7). Diffuse vitreous seeds were present in 18 eyes (47%) which received a mean of 4 injections (median 5; range 1-7). At a mean follow-up of 8.5 months (median 5 months; range 1-15 months), regression of focal and diffuse vitreous seeds was achieved in 16 eyes (80%) and 8 eyes (44%), respectively. In all, 24 eyes (63%) had complete remission of vitreous seeds with POT given concurrently with IVC. Eye salvage was possible in 19 eyes (95%) with focal vitreous seeds and 12 eyes (68%) with diffuse VS. Enucleation was necessary for persistent vitreous seeds and viable tumor in five eyes (13%), viable tumor alone in one eye (0.02%), and recurrent vitreous seeds in one eye (0.02%). None of the patients developed systemic metastasis. Conclusion:POT administered concurrent with IVC is safe and effective in the initial management of vitreous seeds.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Sthapit PR,Rao R,Honavar SGdoi
10.4103/ijo.IJO_737_18subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1833-1838issue
12eissn
0301-4738issn
1998-3689pii
IndianJOphthalmol_2018_66_12_1833_245637journal_volume
66pub_type
杂志文章abstract:Purpose:To determine the changes in central corneal thickness (CCT) during the menstrual cycle in Indian women. Methods:A prospective observational clinical study at a tertiary care center between December 2015 and December 2018. One hundred and twenty sixty women between 18 and 45 years were included. The CCT was mea...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1207_20
更新日期:2020-12-01 00:00:00
abstract::Corneal collagen cross-linking has become the preferred modality of treatment for corneal ectasia since its inception in late 1990s. Numerous studies have demonstrated the safety and efficacy of the conventional protocol. Our understanding of the cross-linking process is ever evolving, with its wide implications in th...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/ijo.IJO_648_17
更新日期:2017-09-01 00:00:00
abstract:Purpose:Pseudoexfoliation syndrome (PXS) is an age related microfibrillopathy characterized by deposition of whitish flaky material over various ocular tissues. PXS eyes are known to have thinner corneas and thus can lead to an underestimation in intraocular pressure measurement. The purpose of this study was to find i...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1899_18
更新日期:2019-10-01 00:00:00
abstract::A, 46-year-old Indian male, known hypertensive presented with left esotropia of 25 prism diopters (PD) after head injury in a roadside accident 9 months back. The deviation was constant in nature and was associated with complaints of diplopia in left lateral gaze. Traumatic sixth nerve palsy was diagnosed. The patien...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.162619
更新日期:2015-06-01 00:00:00
abstract::Globe luxation is a rare clinical event. Most of the cases are usually traumatic, although spontaneous globe luxation has also been reported. The majority of the posttraumatic cases are usually associated with the injury or fracture of the bony orbit. We report here a case of globe luxation that occurred per se withou...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.169795
更新日期:2015-08-01 00:00:00
abstract::In this case report, we describe the rare occurrence of bilateral conjunctival retention cysts in a child with Stevens-Johnson syndrome. The case was managed conservatively as there were no functional or cosmetic problems. ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.37603
更新日期:2008-01-01 00:00:00
abstract::Penetrating orbitocranial injuries can present with foreign body/bodies (FBs) lodged in eye, orbit, and/or brain. But limited literatures are available about FBs lodged partly in orbit and partly intracranially. Here, we present a rare case of orbitocranial wooden FB impacted in right palpebral aperture extending intr...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_569_19
更新日期:2020-01-01 00:00:00
abstract::110 cases of keratomycosis were treated with itraconazole administered either orally or topically or by both routes. Excellent or moderate response was obtained in 69 percent of the patients. Ulcers due to Aspergillus and dematiaceous fungi and non-sevee ulcers responded better than did severe ulcers and ulcers due to...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:Purpose:To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma. Methods:A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better th...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1039_17
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_157_17
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND AIM:Central corneal thickness (CCT) of term and preterm infants in Indian population is not known. We did a prospective noninterventional study to measure the CCT in term and preterm infants. MATERIALS AND METHODS:An ultrasonic pachymeter was used. The data regarding the date of birth, expected date of ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.162601
更新日期:2015-06-01 00:00:00
abstract::Hantavirus infections are an emerging infectious disease that is beginning to be recognized both worldwide and in India as a cause of hemorrhagic fever that may present as a pulmonary syndrome or as a renal syndrome. Reports of ocular involvement are rare and include transient myopia, low intraocular pressure, conjunc...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.33827
更新日期:2007-09-01 00:00:00
abstract::Context (Background): Imiquimod (IMQ) 5% cream is an immunomodulatory and antitumorigenic agent, which was used as a topical treatment regimen, who had periocular basal cell carcinoma (BCC). AIM:This study aims to present three cases with large BCC at the medial canthal area treated with IMQ 5% cream. MATERIALS AND ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_958_16
更新日期:2017-01-01 00:00:00
abstract::"There are many classifications of xerophthalmia in existence. In the present study all these classification have been exhaustively reviewed. Many objections to previous classifications have been raised following experiences with these classifications for over six years. Based on these objections a self explanatory, e...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To report the management outcomes of diplopia in patients with blowout fracture. MATERIALS AND METHODS:Data for 39 patients with diplopia due to orbital blowout fracture were analyzed retrospectively. The inferior wall alone was involved in 22 (56.4%) patients, medial wall alone was involved in 14 (35.8%) pati...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.86313
更新日期:2011-11-01 00:00:00
abstract::Digital fundus imaging is being used in diagnosis, documentation, and sharing of many retinal diseases and hence forms an essential part of ophthalmology. The use of smartphones for the same has been ever increasing. There is a need for simpler devices to couple the 20D lens and smartphone so as to take fundus photogr...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1524_18
更新日期:2019-04-01 00:00:00
abstract::Wet labs are an extremely important training tool, especially in times of a global COVID-19 pandemic, where surgical training can be minimal. They help the trainee learn and practice in a risk-free environment, without an imminent of a complication or failure, also allowing them the chance to execute the steps of a su...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_3298_20
更新日期:2021-02-01 00:00:00
abstract::A 63-year-old female patient complained of dimness in the central field of vision in the left eye after viewing an annular partial eclipse without adequate eye protection on 22 July 2009. Fundoscopy showed a wrinkled macular surface. Fundus autofluorescence study revealed well-demarcated hyperautofluorescence at the f...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.103799
更新日期:2012-11-01 00:00:00
abstract::Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. The treatment of choice is excision biopsy. Histopath...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_1185_17
更新日期:2018-05-01 00:00:00
abstract::Thirty-three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative or postoperative 5-Fluorouracil (5-FU) use. Twelve eyes serving as controls underwent trabeculectomy withou...
journal_title:Indian journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-09-01 00:00:00
abstract::In this report we describe nongranulomatous uveitis followed by bilateral retinal vasculitis and much later by the loss of accommodation as initial presentations of demyelinating disease in a 42-year-old female with no other neurologic manifestations. The absence of demyelinating plaques in the initial magneric resona...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_2017_19
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The thesis is an integral part of postgraduate medical education in India. Publication of the results of the thesis in an indexed journal is desirable; it validates the research and makes results available to researchers worldwide. AIMS:To determine publication rates in indexed journals, of works derived fr...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.60070
更新日期:2010-03-01 00:00:00
abstract:Purpose:To compare and study the clinical outcome of tarsorrhaphy and amniotic membrane transplant in the healing of persistent corneal epithelial defects in terms of clinical improvement and symptomatic relief. Methods:This was an interventional, prospective study in which a total of 60 patients with persistent epith...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_617_19
更新日期:2020-01-01 00:00:00
abstract::Since the year 2000, the amount written about the economics of blindness and visual impairment has increased substantially. In some cases, the studies listed under this heading are calculations of the costs related to vision impairment and blindness at a national or global level; in other cases the studies examine the...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/0301-4738.100535
更新日期:2012-09-01 00:00:00
abstract::An unusual case of cyclic pupillary movements in an otherwise complete oculomotor nerve palsy in a five year-old girl is reported. This is considered to be due to destruction of somatic and visceral nuclei of the oculomotor nerve following injury to its fascicular part. Pupillary automatism has been explained on the b...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:It has been frequently stated that the orbital decompression, in patients with thyroid ophthalmopathy, does not usually improve extraocular muscles function and that after the operation there is often a deterioration of these functions. The purpose of this article is evaluation of extraocular muscles function a...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.120206
更新日期:2014-03-01 00:00:00
abstract:: ...
journal_title:Indian journal of ophthalmology
pub_type: 社论
doi:10.4103/ijo.IJO_2074_18
更新日期:2019-01-01 00:00:00
abstract::The incidence of the craniofacial cleft is rare ranging between 1.43 and 4.85/100,000 births. Tessier number nine cleft being the rarest, there are a few reports of detailed ophthalmologic examinations performed in them. In this study, 1-day-old female neonate delivered by normal vaginal delivery at term, weighing 148...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_914_16
更新日期:2017-07-01 00:00:00
abstract::The present study analyses the precorneal teat film using schirmer's test and tear film breakup time (BKUT) in 400 eyes of patients with various types of leprosy. An abnormal tear film BKUT (47.2%) was observed to be much more informative in the present series than the study of schirmer's test alone (25.4%). In patien...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Glaucoma care is more an art than science. The introduction of several new classes of glaucoma medications and the completion of many large randomized clinical trials have not changed this fact. While we now have better choices when initiating glaucoma therapy relative to our predecessors, the principles of glaucoma t...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.73691
更新日期:2011-01-01 00:00:00