Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area.

Abstract:

:Context (Background): Imiquimod (IMQ) 5% cream is an immunomodulatory and antitumorigenic agent, which was used as a topical treatment regimen, who had periocular basal cell carcinoma (BCC). AIM:This study aims to present three cases with large BCC at the medial canthal area treated with IMQ 5% cream. MATERIALS AND METHODS:IMQ 5% cream was used in three patients with ages 45, 49, and 73 who preferred medical treatment over surgery. Following incisional biopsy IMQ cream was used once a day, 5 times a week and the patients were followed up weekly during 12 week treatment period and monthly after the clearance of the lesion. RESULTS:Erythema and erosion on the surface of the lesion, injection of conjunctiva, burning and itching sensation, epiphora and punctate keratitis were seen in all patients during the treatment period. The ophthalmic side effects could be managed by topical lubricating eye drops and the inflammatory reactions resolved within 1 month after cessation of therapy. The patients were followed up for at least 3 years without tumor recurrence and the biopsies taken from the suspected area were found to be tumor free. CONCLUSION:Surgical excision of carcinoma of the eyelid at medial canthal area can be difficult without causing damage to the lacrimal system and reconstruction of the defect may need grafts or flaps. IMQ may provide an alternative therapy to surgery in certain cases.

journal_name

Indian J Ophthalmol

authors

Karabulut GO,Kaynak P,Ozturker C,Fazil K,Ocak OB,Taskapılı M

doi

10.4103/ijo.IJO_958_16

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

48-51

issue

1

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2017_65_1_48_202318

journal_volume

65

pub_type

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