Abstract：
:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing the sixth leading cause of cancer and the third leading cause of cancer-related mortality. Patient stratification and treatment allocation are based on tumor stage, liver function, and performance status. According to the Barcelona Clinic Liver Cancer (BCLC) staging system, transarterial chemoembolization (TACE) is the first-line treatment for patients with intermediate stage HCC, including those with large or multinodular HCC, well-preserved liver function, and no cancer-related symptoms or evidence of vascular invasion or extrahepatic spread. Two TACE techniques have been used since 2004, conventional TACE (cTACE) and TACE with drug-eluting beads (DEB-TACE). cTACE was evidenced first to treat intermediate stage HCC patients. It combines the transcatheter delivery of chemotherapy using Lipiodol-based emulsion plus an embolizing agent to achieve strong cytotoxic and ischemic effects. Drug-eluting beads (DEBs) were developed in order to slowly release chemotherapeutic agents, and to increase ischemia intensity and duration. Recent advances allow TACE treatment of both early stage patients (i.e. those with a solitary nodule or up to 3 nodules under 3 cm) and some advanced stage patients. Here we review recent clinical evidence related to TACE treatment of patients with early, intermediate, and advanced stage HCC. Based on the 2014 TACE algorithm of Raoul et al., this international expert panel proposes an updated TACE algorithm and provides insights into TACE use for patients at any HCC stage.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Raoul JL,Forner A,Bolondi L,Cheung TT,Kloeckner R,de Baere Tdoi
10.1016/j.ctrv.2018.11.002subject
Has Abstractpub_date
2019-01-01 00:00:00pages
28-36eissn
0305-7372issn
1532-1967pii
S0305-7372(18)30194-4journal_volume
72pub_type
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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更新日期：2006-10-01 00:00:00
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journal_title：Cancer treatment reviews
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更新日期：2011-11-01 00:00:00
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2011.01.003
更新日期：2011-10-01 00:00:00
abstract：:Metastatic cervical carcinoma from unknown primary is a metastatic disease in the lymph nodes of the neck without any evidence of a primary tumour after appropriate investigation. The condition is rare and definite evidence is lacking for both diagnosis and treatment. In this review of the literature, we tried to draw...
journal_title：Cancer treatment reviews
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更新日期：2017-02-01 00:00:00
