Abstract:
:The first-generation epidermal growth factor receptor tyrosine kinase inhibitors erlotinib and gefitinib have been incorporated into treatment paradigms for patients with advanced non-small cell lung cancer. These agents are particularly effective in a subset of patients whose tumors harbor activating epidermal growth factor receptor mutations. However, most patients do not respond to these tyrosine kinase inhibitors, and those who do will eventually acquire resistance that typically results from a secondary epidermal growth factor receptor mutation (e.g., T790M), mesenchymal-epithelial transition factor amplification, or activation of other signaling pathways. For patients whose tumors have wild-type epidermal growth factor receptor, there are several known mechanisms of initial resistance (e.g., Kirsten rat sarcoma viral oncogene homolog mutations) but these do not account for all cases, suggesting that unknown mechanisms also contribute. To potentially overcome the issue of resistance, next-generation tyrosine kinase inhibitors are being developed, which irreversibly block multiple epidermal growth factor receptor family members (e.g., afatinib [BIBW 2992] and PF-00299804) and/or vascular endothelial growth factor receptor pathways (e.g., BMS-690514 and XL647). In addition, drugs that block parallel signaling pathways or signaling molecules downstream of the epidermal growth factor receptor, such as the insulin-like growth factor-1 receptor and the mammalian target of rapamycin, are undergoing clinical evaluation. As drug resistance appears to be pleomorphic, combinations of drugs or drugs with multiple targets may be more effective in circumventing resistance.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Giaccone G,Wang Ydoi
10.1016/j.ctrv.2011.01.003subject
Has Abstractpub_date
2011-10-01 00:00:00pages
456-64issue
6eissn
0305-7372issn
1532-1967pii
S0305-7372(11)00019-3journal_volume
37pub_type
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
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pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2008.01.004
更新日期:2008-06-01 00:00:00
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journal_title:Cancer treatment reviews
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更新日期:2003-08-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2010.08.007
更新日期:2011-06-01 00:00:00
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更新日期:1996-01-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2006.12.004
更新日期:2007-05-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2011.04.004
更新日期:2011-11-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2013.10.001
更新日期:2014-05-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2014.10.008
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2015.11.005
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pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2017.06.001
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pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2020.102022
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pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
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pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2015.03.010
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pub_type: 杂志文章,评审
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abstract::Lung cancer represents the most common cause of brain dissemination. Oncogene-addicted (EGFR- and ALK-positive) non-small cell lung cancers (NSCLCs) are characterized by a unique metastatic neurotropism resulting in a particularly high incidence of brain metastases. The goal of optimal brain metastases management is t...
journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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abstract::Metastatic colorectal cancer remains a public-health issue on a global scale. With development of a new generation of cytotoxic agents, survival has improved for patients with metastatic disease. How to maximize the benefit of chemotherapy with acceptable toxicity remains incompletely answered. Hepatic resection can p...
journal_title:Cancer treatment reviews
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更新日期:2006-11-01 00:00:00