Alternative formulations of paclitaxel.

Abstract:

:Paclitaxel, a novel antitumour agent, is active clinically against advanced ovarian and breast cancer and under investigation for various other cancers. One of the problems associated with the intravenous administration of paclitaxel is its low solubility in water. The current pharmaceutical formulation consists of a 1:1 (v/v) mixture of ethanol and Cremophor EL. This formulation, however, has been demonstrated to cause some severe hypersensitivity reactions. Therefore the development of a safer intravenous formulation devoid of Cremophor EL is an important investigational issue. This review deals with some of the most promising formulation alternatives.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Terwogt JM,Nuijen B,Huinink WW,Beijnen JH

doi

10.1016/s0305-7372(97)90022-0

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

87-95

issue

2

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(97)90022-0

journal_volume

23

pub_type

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