AR-V7 and prostate cancer: The watershed for treatment selection?

Abstract:

:The androgen receptor (AR) plays a key role in progression to metastatic castration-resistant prostate cancer (mCRPC). Despite the recent progress in targeting persistent AR activity with the next-generation hormonal therapies (abiraterone acetate and enzalutamide), resistance to these agents limits therapeutic efficacy for many patients. Several explanations for response and/or resistance to abiraterone acetate and enzalutamide are emerging, but growing interest is focusing on importance of AR splice variants (AR-Vs) and in particular of AR-V7. Increasing evidences highlight the concept that variant expression could be used as a potential predictive biomarker and a therapeutic target in advanced prostate cancer. Therefore, understanding the mechanisms of treatment resistance or sensitivity can help to achieve a more effective management of mCRPC, increasing clinical outcomes and representing a promising and engaging area of prostate cancer research.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Ciccarese C,Santoni M,Brunelli M,Buti S,Modena A,Nabissi M,Artibani W,Martignoni G,Montironi R,Tortora G,Massari F

doi

10.1016/j.ctrv.2015.12.003

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

27-35

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(15)00248-0

journal_volume

43

pub_type

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