Estrogen receptor-negative progesterone receptor-positive breast cancer - "Nobody's land" or just an artifact?

Abstract:

:The estrogen receptor α (ER) and the progesterone receptor (PgR) are one of the most important prognostic and predictive immunohistochemical markers in breast cancer. Breast cancers may express various profiles of hormone receptors: ER(+)/PgR(+), ER(-)/PgR(-), ER(+)/PgR(-) and ER(-)/PgR(+). The existence of the latter profile is a matter of controversy since PgR expressions is induced by ER-dependent pathways in breast cancer cells. One of the most extensively propagated hypotheses trying to explain the origin of ER(-)/PgR(+) breast cancers claims that they are technical artifacts dependent on the immunohistochemical procedure. On the other hand, in recent years there is a growing body of evidence, suggesting that such cancers create a unique group with distinct molecular and clinical features. In the following review, we present background theories on the ER(-)/PgR(+) breast cancer origin and their epidemiological and clinicopathological characteristics, including the predictive and prognostic significance of these rare tumors.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Kunc M,Biernat W,Senkus-Konefka E

doi

10.1016/j.ctrv.2018.05.005

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

78-87

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(18)30068-9

journal_volume

67

pub_type

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