PARP inhibitors in ovarian cancer.

abstract：:Biliary tract cancer is a quite rare disease; despite recent significant advances in imaging modalities, most of the patients have advanced disease at presentation thus making radical surgery not feasible. Many different chemotherapeutic regimens have been investigated in small uncontrolled studies, with generally dis...

journal_title：Cancer treatment reviews

authors： Berardi R,Scartozzi M,Freddari F,Squadroni M,Santinelli A,Bearzi I,Fabris G,Cascinu S

更新日期：2006-08-01 00:00:00

abstract：:Recent advances in RNA delivery and target selection provide unprecedented opportunities for cancer treatment, especially for cancers that are particularly hard to treat with existing drugs. Small interfering RNAs, microRNAs, and antisense oligonucleotides are the most widely used strategies for silencing gene express...

journal_title：Cancer treatment reviews

authors： Barata P,Sood AK,Hong DS

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Surgery is the only curative treatment for primary cutaneous melanoma, therefore it is important to determine excision margins that minimise risk of local recurrence, distant recurrence and death. METHODS:MEDLINE, EMBASE and Cochrane CENTRAL were searched from 2009 to 2015. Inclusion criteria were: populati...

journal_title：Cancer treatment reviews

authors： Wheatley K,Wilson JS,Gaunt P,Marsden JR

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To summarize and define the methodological quality of primary research findings obtained in exercise interventions, aimed at improving physical function or psychological well-being in patients treated for haematological malignancies. METHODS:Relevant trials were identified through a computerized Mesh-search in...

journal_title：Cancer treatment reviews

authors： Liu RD,Chinapaw MJ,Huijgens PC,van Mechelen W

更新日期：2009-04-01 00:00:00

abstract：:Biliary tract cancers (BTCs) are a group of invasive neoplasms, with increasing incidence and dismal prognosis. In advanced disease, the standard of care is represented by first-line chemotherapy with cisplatin and gemcitabine. In subsequent lines, no clear recommendations are currently available, highlighting the nee...

journal_title：Cancer treatment reviews

authors： Corti F,Nichetti F,Raimondi A,Niger M,Prinzi N,Torchio M,Tamborini E,Perrone F,Pruneri G,Di Bartolomeo M,de Braud F,Pusceddu S

更新日期：2019-01-01 00:00:00

abstract：:Approximately 5-10% of breast cancer cases might be inheritable, up to 30% of which are due to BRCA1/2 mutations. During the past few years and thanks to technology evolution, we have been witnesses of an intensive search of additional genes with similar characteristics, under the premise that successful gene discover...

journal_title：Cancer treatment reviews

authors： Economopoulou P,Dimitriadis G,Psyrri A

更新日期：2015-01-01 00:00:00

abstract：:Attribution of adverse events (AEs) is critical to oncology drug development and the regulatory process. However, processes for determining the causality of AEs are often sub-optimal, unreliable, and inefficient. Thus, we conducted a toxicity-attribution workshop in Silver Springs MD to develop guidance for improving ...

journal_title：Cancer treatment reviews

authors： George GC,Barata PC,Campbell A,Chen A,Cortes JE,Hyman DM,Jones L,Karagiannis T,Klaar S,Le-Rademacher JG,LoRusso P,Mandrekar SJ,Merino DM,Minasian LM,Mitchell SA,Montez S,O'Connor DJ,Pettit S,Silk E,Sloan JA,Stewar

更新日期：2019-06-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a non-receptor intracellular kinase that belongs to the TEC-family tyrosine kinases together with bone marrow-expressed kinase (BMX), redundant-resting lymphocyte kinase (RLK), and IL-2 inducible T-Cell kinase (ITK). All these proteins play a key role in the intracellular signaling of...

journal_title：Cancer treatment reviews

authors： Molina-Cerrillo J,Alonso-Gordoa T,Gajate P,Grande E

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The immune system plays an important role in cancer pathogenesis. A low lymphocyte-to-monocyte ratio (LMR), as a simple biomarker of host immune system, has been suggested to be related to poor prognosis in various cancers. We performed a systematic review and meta-analysis to quantify the prognostic value o...

journal_title：Cancer treatment reviews

authors： Nishijima TF,Muss HB,Shachar SS,Tamura K,Takamatsu Y

更新日期：2015-12-01 00:00:00

abstract：:Immunotherapy represents a major breakthrough in cancer therapy in recent years. Immune-checkpoint blockade using PD-1 and PD-L1 antibodies appears to be one of the most promising immunotherapy approaches. Immunotherapy differs from conventional cancer treatment because of its ability to produce durable responses in s...

journal_title：Cancer treatment reviews

authors： Lote H,Cafferkey C,Chau I

更新日期：2015-12-01 00:00:00

abstract：:Vinorelbine is a semi-synthetic vinca alkaloid that has been shown active in many tumour types and is currently registered for the treatment of advanced breast cancer (ABC) and non-small cell lung cancer (NSCLC). This agent has a generally favourable safety profile, and may be suitable for use in special populations s...

journal_title：Cancer treatment reviews

authors： Mano M

更新日期：2006-04-01 00:00:00

abstract：:Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of oxygen, due to exponential cellular proliferation and an inefficient vascular supply. It is an adverse prognostic indicator in cancer as it is associated with ...

journal_title：Cancer treatment reviews

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2003-08-01 00:00:00

abstract：:Bone-seeking radionuclides, such as Sr-89, Sm-153, and Re-186, have been shown to have an effect on pain from bone metastasis in prostate cancer. The effect on bone pain in other cancer types, including breast cancer, remains unclear. The purpose of the study was to perform a systematic review of the use of radioisoto...

journal_title：Cancer treatment reviews

authors： Christensen MH,Petersen LJ

更新日期：2012-04-01 00:00:00

abstract：:The estrogen receptor α (ER) and the progesterone receptor (PgR) are one of the most important prognostic and predictive immunohistochemical markers in breast cancer. Breast cancers may express various profiles of hormone receptors: ER(+)/PgR(+), ER(-)/PgR(-), ER(+)/PgR(-) and ER(-)/PgR(+). The existence of the latter...

journal_title：Cancer treatment reviews

authors： Kunc M,Biernat W,Senkus-Konefka E

更新日期：2018-06-01 00:00:00

abstract：:Despite the available prevention and early detection strategies, advanced squamous-cell carcinoma of the uterine cervix remains a major concern for public health. Systemic treatment with cisplatin, either in combination with external beam irradiation for locally advanced disease, or as monotherapy for recurrent/metast...

journal_title：Cancer treatment reviews

authors： Mountzios G,Soultati A,Pectasides D,Pectasides E,Dimopoulos MA,Papadimitriou CA

更新日期：2013-08-01 00:00:00

abstract：:The availability of sensitive methods has allowed the detailed study of circulating tumor cells only recently. Evolving evidence support the prognostic and predictive role of these cells in patients affected by several solid tumors, including colorectal cancer. Ongoing studies are aimed at confirming that the molecula...

journal_title：Cancer treatment reviews

authors： Torino F,Bonmassar E,Bonmassar L,De Vecchis L,Barnabei A,Zuppi C,Capoluongo E,Aquino A

更新日期：2013-11-01 00:00:00

abstract：:Metastatic breast cancer is ultimately an incurable disease, although recent data have shown that its incidence is decreasing and that patients with metastatic breast cancer live longer. This improvement in survival seems to be linked with the introduction of new therapeutic agents, novel combinations of existing ther...

journal_title：Cancer treatment reviews

authors： Fernández Y,Cueva J,Palomo AG,Ramos M,de Juan A,Calvo L,García-Mata J,García-Teijido P,Peláez I,García-Estévez L

更新日期：2010-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most common gynaecological malignancy in the Western world and a leading cause of death. Patients with relapsed EOC are incurable and therefore the toxicity of palliative chemotherapy and effects on health-related Quality of Life are important factors. Several newer cytotoxic age...

journal_title：Cancer treatment reviews

authors： Stebbing J,Gaya A

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients' own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have ...

journal_title：Cancer treatment reviews

authors： Verbrugghe M,Verhaeghe S,Lauwaert K,Beeckman D,Van Hecke A

更新日期：2013-10-01 00:00:00

abstract：:The chemo-immunotherapy (CIT) and chemo-adoptive immunotherapy (CAIT) regimens tested in the past decade are summarized. From them we have learned a great deal about the interactions between various chemotherapeutic agents, immune modulating agents and effector cells. The most commonly reported result in multi-modalit...

journal_title：Cancer treatment reviews

authors： Gomez GG,Hutchison RB,Kruse CA

更新日期：2001-12-01 00:00:00

abstract：:Cancer treatment is the most frequent cause of reduced fertility in cancer patients, with up to 80% of survivors affected. None of the established or experimental fertility preservation methods can assure parenthood, rather they may provide a future opportunity to overcome treatment induced sterility. Around 70-75% of...

journal_title：Cancer treatment reviews

authors： Linkeviciute A,Boniolo G,Chiavari L,Peccatori FA

更新日期：2014-09-01 00:00:00

abstract：:This review summarizes emerging information regarding the Hedgehog (Hh) signaling pathway during neoplastic transformation in the gastrointestinal tract. Although there is a role for the well-established canonical pathway in which Hedgehog ligands interact with their receptor Patched, there is sufficient evidence that...

journal_title：Cancer treatment reviews

authors： Merchant JL,Saqui-Salces M

更新日期：2014-02-01 00:00:00

abstract：:The existence of branchiogenic carcinoma remains controversial. According to some authors, this malignancy is more conceptual than a true clinicopathologic entity. The originally proposed diagnostic criteria of branchiogenic carcinoma have been subsequently challenged. Many reports regarding primary branchiogenic carc...

journal_title：Cancer treatment reviews

authors： Jereczek-Fossa BA,Casadio C,Jassem J,Luzzatto F,Viale G,Bruschini R,Chiesa F,Orecchia R

更新日期：2005-04-01 00:00:00

abstract：:Despite the initially high response rate to standard front-line debulking surgery followed by platinum-based chemotherapy, the relapse rate in ovarian cancer is high and many patients will recur within 6 months of completing platinum based treatment. These patients may still require further chemotherapy despite being ...

journal_title：Cancer treatment reviews

authors： Pinato DJ,Graham J,Gabra H,Sharma R

更新日期：2013-04-01 00:00:00

abstract：:The present study describes a female child, who had a primary defect in the ability of her T-cells to secrete interleukin-2. Numbers of B- and T-cells were normal, but their functions were severely deficient. The patient had decreased immunoglobulins and poor ability to mount antibody responses. Phytohemagglutinin (PH...

journal_title：Cancer treatment reviews

authors： Pahwa R,Paradise C,Good RA

更新日期：1989-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the biggest cancer killer in the United States and worldwide. In 2011, there are estimated to be 221,130 new cases of lung cancer in the United States. Over a million people will die of lung cancer worldwide this year alone. When possible, surgery to remove the tumor is the best t...

journal_title：Cancer treatment reviews

authors： Tucker ZC,Laguna BA,Moon E,Singhal S

更新日期：2012-10-01 00:00:00

abstract：:Sarcomas of the head and neck region are a rare group of tumors in children and present challenges with regard to evaluation and treatment. Rhabdomyosarcomas are the most common sarcomas of the head and neck in children. Presence of metastases and complete surgical resectability continue to be the most relevant clinic...

journal_title：Cancer treatment reviews

authors： Huh WW,Fitzgerald N,Mahajan A,Sturgis EM,Beverly Raney R,Anderson PM

更新日期：2011-10-01 00:00:00

abstract：:The use of megestrol acetate in treatment of malignancy (endometrial carcinoma, ovarian cancer, prostate cancer, breast cancer, renal cell carcinoma, malignant melanoma), endometrial hyperplasia, benign prostatic hypertrophy, contraception, anorexia, cachexia and weight loss is reviewed, concluding with a toxicity pro...

journal_title：Cancer treatment reviews

authors： Schacter L,Rozencweig M,Canetta R,Kelley S,Nicaise C,Smaldone L

更新日期：1989-03-01 00:00:00

abstract：:Two regimens were tested, CHAP I and CHAP II, the latter, a hexamethylmelamine dosage-intensive regimen, first as second line (salvage) therapy and then as primary therapy. Both produced the most successful results achieved in the Mount Sinai series up to the time of their introduction, when compared to their predeces...

journal_title：Cancer treatment reviews

authors： Bruckner HW,Cohen C,Mandeli J,Chesser MR,Kabakow B,Wallach R,Holland J

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To conduct a systematic review and meta-analysis of all phase III randomized controlled trials comparing efficacy of early versus late first-line or initial treatments for cancer. METHODS:A comprehensive literature search of MEDLINE and Cochrane library databases was performed (1966-2008). Data was extracted a...

journal_title：Cancer treatment reviews

authors： Mhaskar AR,Quinn G,Vadaparampil S,Djulbegovic B,Gwede CK,Kumar A

更新日期：2010-12-01 00:00:00