Abstract:
:The present study describes a female child, who had a primary defect in the ability of her T-cells to secrete interleukin-2. Numbers of B- and T-cells were normal, but their functions were severely deficient. The patient had decreased immunoglobulins and poor ability to mount antibody responses. Phytohemagglutinin (PHA) and antigen-driven lymphoproliferative responses were diminished and were correctable in vitro with exogenous IL-2. Upon stimulation with PHA the patient's lymphocytes expressed IL-2 receptors normally, but were grossly deficient in endogenous IL-2 production. The patient was diagnosed as having a form of severe combined immunodeficiency disease at 6 months of age. Two attempts at immune reconstitution by haploidentical bone marrow transplantation failed to result in sustained engraftment. At age 18 months, treatment was initiated with rIL-2 10,000 units/kg i.v. daily and gradually increased to 30,000 units/kg. A marked improvement was noted, clinically as well as in T-cell immune functions. The child has been maintained on rIL-2 treatment at home for the past year without significant adverse effects, and she is currently receiving 30,000 units/kg of rIL-2 three times a week. This case illustrates that IL-2 is a potentially useful therapeutic modality which can be safely administered for prolonged periods to children with primary immunodeficiency diseases.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Pahwa R,Paradise C,Good RAdoi
10.1016/0305-7372(89)90034-0subject
Has Abstractpub_date
1989-06-01 00:00:00pages
143-9eissn
0305-7372issn
1532-1967pii
0305-7372(89)90034-0journal_volume
16 Suppl Apub_type
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2019.05.003
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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doi:10.1016/j.ctrv.2010.08.007
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
pub_type: 杂志文章
doi:10.1016/0305-7372(90)90012-5
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2007.06.003
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2013.10.001
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.ctrv.2016.11.014
更新日期:2017-02-01 00:00:00
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
pub_type: 临床试验,杂志文章,随机对照试验,评审
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journal_title:Cancer treatment reviews
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
pub_type: 杂志文章,评审
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journal_title:Cancer treatment reviews
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pub_type: 杂志文章,评审
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