Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review.

Abstract:

BACKGROUND AND AIMS:The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients' own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have been reported. A systematic literature review was conducted to gain insight into determinants and associated factors of non-adherence and non-persistence in patients taking oral anticancer therapy. REVIEW METHODS:PubMed, Cochrane, Web of Science and Cinahl were systematically searched for studies focusing on determinants and associated factors of medication non-adherence and non-persistence to oral anticancer drugs. The methodological quality of the included studies was assessed by two independent reviewers. No studies were excluded based on the quality assessment. RESULTS:Twenty-five studies were included and systematically reviewed. The quality of the studies was moderate. Associated factors influencing medication non-adherence and non-persistence to oral anticancer drugs are multifactorial and interrelated. Older and younger age, and the influence of therapy related side effects were found to be predominant factors. CONCLUSION:Non-adherence and non-persistence to oral anticancer drug therapy are complex phenomena. More qualitative research is needed to facilitate the development of patient tailored complex interventions by exploring patients' needs and underlying processes influencing medication non-adherence and non-persistence to oral anticancer drugs.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Verbrugghe M,Verhaeghe S,Lauwaert K,Beeckman D,Van Hecke A

doi

10.1016/j.ctrv.2012.12.014

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

610-21

issue

6

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(13)00010-8

journal_volume

39

pub_type

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