Abstract：
:Sarcomas of the head and neck region are a rare group of tumors in children and present challenges with regard to evaluation and treatment. Rhabdomyosarcomas are the most common sarcomas of the head and neck in children. Presence of metastases and complete surgical resectability continue to be the most relevant clinical prognostic factors in patients with sarcomas. However, many patients present with unresectable tumors; these require radiation therapy, which is associated with concerns about immediate and long-term side effects. New technologies, including proton beam therapy (PBT), appear very promising in terms of reducing acute and long-term toxic effects. A multi-disciplinary approach is required for best long-term outcomes in children with head and neck sarcomas.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Huh WW,Fitzgerald N,Mahajan A,Sturgis EM,Beverly Raney R,Anderson PMdoi
10.1016/j.ctrv.2011.04.005subject
Has Abstractpub_date
2011-10-01 00:00:00pages
431-9issue
6eissn
0305-7372issn
1532-1967pii
S0305-7372(11)00067-3journal_volume
37pub_type
杂志文章,评审abstract：:Fulvestrant is a selective estrogen receptor downregulator, behaving as a complete antagonist. It was initially approved, at a dose of 250 mg, to treat hormone dependant breast cancer in second line setting. However, a series of pharmacological and pre-clinical studies have suggested that a higher dose of 500 mg may b...
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