Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy.

Abstract:

:The prognosis of advanced pancreatic adenocarcinoma is still poor nowadays. Gemcitabine in monotherapy (30-min infusion) has been the standard of treatment during the last decade, and many clinical trials have failed to demonstrate an improvement in overall survival (OS) with the addition of different drugs to gemcitabine, including cetuximab and bevacizumab. Nevertheless, some modest but interesting advances have been provided by combinations such as gemcitabine-erlotinib, gemcitabine-capecitabine and gemcitabine plus a platinum salt. In spite of this, survival results remain disappointing. Further research focused on new combinations, incorporating the new targeted therapies and identifying potential predictive factors of response are required to be able to offer effective tailored therapies to these patients.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Rivera F,López-Tarruella S,Vega-Villegas ME,Salcedo M

doi

10.1016/j.ctrv.2008.11.007

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

335-9

issue

4

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(08)00322-8

journal_volume

35

pub_type

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