Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English language literature.

Abstract:

BACKGROUND:Different modalities of treatment in early laryngeal cancer lead to equivalent oncological outcomes. Hence this systematic review was undertaken to synthesise the key oncological outcomes following primary open partial laryngectomy for laryngeal cancer. METHODS:A systematic review of the English literature with statistical pooling of outcomes, the main outcome measure being local control at 24 months. RESULTS:A total of 53 articles satisfied inclusion criteria and were included in the review. The pooled local control rate at 24 months from 5061 patients was 89.8% (95% CI 88.3-91.2), pooled overall survival was 79.7% (n = 3967; 95% CI 76.5-782.8) and pooled mean disease free survival was 84.8% (n = 2344; 95% CI 80.6-88.7). The pooled mean operative mortality, laryngectomy for function, tracheostomy decannulation and permanent gastrostomy rates were 0.7%, 1.7%, 96.3%, and 2.0%, respectively. CONCLUSIONS:Open conservation laryngectomy is a good option in selected primary laryngeal cancers with excellent oncological outcomes.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Thomas L,Drinnan M,Natesh B,Mehanna H,Jones T,Paleri V

doi

10.1016/j.ctrv.2011.05.010

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

203-11

issue

3

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(11)00103-4

journal_volume

38

pub_type

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