Comparison of radiological criteria for hyperprogressive disease in response to immunotherapy.


:Hyperprogressive disease (HPD) is a concerning paradoxical acceleration of cancer growth induced by immune drugs. The lack of standard radiological criteria makes its study challenging. We reviewed the literature and compared the main criteria for HPD proposed by Ferté, Le Tourneau, Garralda and Caramella to address this relevant unmet need in Immune-oncology. Among 182 consecutive patients with advanced cancer treated with immunotherapy in early-phase clinical trials, 71 with progressive disease at the first evaluation were eligible. HPD patients were studied regarding tumor growth dynamics and clinical impact. HPD occurred in 17 (23.9%), 17 (23.9%), 23 (32.4%) and 6 (8.4%) patients, as defined by Ferté, Le Tourneau, Garralda and Caramella, respectively. The strongest association was found between the Ferté and Le Tourneau criteria (Kappa = 0.61), and the Jaccard similarity index varied from 55% (Ferté and Le Tourneau) to 21% (Le Tourneau and Caramella). The Ferté and Le Tourneau criteria showed statistically significant differences between pre-baseline and post-baseline tumor growth rate in patients with HPD, which could not be confirmed with the Caramella and Garralda criteria. Significant differences in progression-free survival were observed between non-hyperprogressors and hyperprogressors, with all criteria. The proportion of patients that could not receive additional lines of therapy was higher in the HPD group. HPD is an immunotherapy-related acceleration of tumor growth kinetics, with a consequent negative clinical impact. Pre-baseline CT scans and tumor growth rate evaluations are required to identify HPD. Our analysis favors the use of the Le Tourneau method, as it captures adequately the HPD phenomenon and is more convenient to use.


Cancer Treat Rev


Cancer treatment reviews


Gomes da Morais AL,de Miguel M,Cardenas JM,Calvo E




Has Abstract


2020-12-01 00:00:00












  • Relevance of high-dose chemotherapy in solid tumours.

    abstract::Drug resistance is a major problem in the treatment of solid tumours. Based on a steep dose-response relationship for especially alkylating agents on tumour cell survival, high-dose chemotherapy was considered of interest for the treatment of solid tumours. Results of phase 1 and 2 studies with high-dose chemotherapy ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Nieboer P,de Vries EG,Mulder NH,van der Graaf WT

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  • Surgical excision margins in primary cutaneous melanoma: A meta-analysis and Bayesian probability evaluation.

    abstract:BACKGROUND:Surgery is the only curative treatment for primary cutaneous melanoma, therefore it is important to determine excision margins that minimise risk of local recurrence, distant recurrence and death. METHODS:MEDLINE, EMBASE and Cochrane CENTRAL were searched from 2009 to 2015. Inclusion criteria were: populati...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


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  • Management of brain metastasized non-small cell lung cancer (NSCLC) - From local treatment to new systemic therapies.

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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • Comparison of outcomes and toxicities among radiation therapy treatment options for prostate cancer.

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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


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    pub_type: 杂志文章


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

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    更新日期:2016-12-01 00:00:00

  • Lymphatic spread, nodal count and the extent of lymphadenectomy in cancer of the colon.

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    journal_title:Cancer treatment reviews

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    journal_title:Cancer treatment reviews

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  • Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review.

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    journal_title:Cancer treatment reviews

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    journal_title:Cancer treatment reviews

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    更新日期:2000-06-01 00:00:00

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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


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