Targeting uPA/uPAR in prostate cancer.


:Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases). The invasive ability of tumour cells plays a key role in CaP metastasis and is a major cause of treatment failure. Urokinase plasminogen activator (uPA) and its receptor (uPAR)-mediated signalling have been implicated in tumour cell invasion, survival, and metastasis in a variety of cancers including CaP. Both uPA and uPAR are expressed at much higher levels in CaP tissues than in benign and normal prostate tissues. They are used as diagnostic markers as well as therapeutic targets due to their aberrant and unique expression pattern during cancer progression. Current therapeutic options for patients with metastatic hormone-refractory CaP (HRPC) are very limited. Therefore, much effort is currently being directed toward targeting aberrant uPA or uPAR activity in CaP. This review summarizes some important new findings supporting the role of uPA/uPAR in CaP progression and establishing the potential therapeutic efficacy of uPA/uPAR-targeted therapies in CaP.


Cancer Treat Rev


Cancer treatment reviews


Li Y,Cozzi PJ




Has Abstract


2007-10-01 00:00:00














  • Pediatric sarcomas and related tumors of the head and neck.

    abstract::Sarcomas of the head and neck region are a rare group of tumors in children and present challenges with regard to evaluation and treatment. Rhabdomyosarcomas are the most common sarcomas of the head and neck in children. Presence of metastases and complete surgical resectability continue to be the most relevant clinic...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Huh WW,Fitzgerald N,Mahajan A,Sturgis EM,Beverly Raney R,Anderson PM

    更新日期:2011-10-01 00:00:00

  • The promise of selective MET inhibitors in non-small cell lung cancer with MET exon 14 skipping.

    abstract::Dysregulated activation of the MET tyrosine kinase receptor is implicated in the development of solid tumors and can arise through several mechanisms, including gene amplification, overexpression of the receptor and/or its ligand hepatocyte growth factor (HGF), and the acquisition of activating mutations. The most com...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Salgia R,Sattler M,Scheele J,Stroh C,Felip E

    更新日期:2020-07-01 00:00:00

  • Practical management of tyrosine kinase inhibitor-associated side effects in GIST.

    abstract::Patients diagnosed with advanced gastrointestinal stromal tumor (GIST) are currently treated with oral tyrosine kinase inhibitors (TKIs). Imatinib mesylate is the standard first-line treatment, and sunitinib malate is administered second-line for patients who are intolerant or progress on imatinib. Imatinib has recent...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Joensuu H,Trent JC,Reichardt P

    更新日期:2011-02-01 00:00:00

  • Second-line therapy for advanced pancreatic cancer: a review of the literature and future directions.

    abstract::Whereas first-line chemotherapy (CT) with single-agent gemcitabine or gemcitabine-based combinations provides a proven benefit in patients with locally advanced or metastatic pancreatic cancer (PC), the role of salvage CT after gemcitabine-failure is not well-established and to date no regimen has emerged as preferred...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Custodio A,Puente J,Sastre J,Díaz-Rubio E

    更新日期:2009-12-01 00:00:00

  • Immunomodulation therapy in colorectal carcinoma.

    abstract::There has been much progress in the understanding of the relationship between the immune system and colorectal cancer. This has led to the use of immunomodulatory therapy in the adjuvant and palliative treatment of the condition. Although attempts at the use of non-specific immunomodulation with agents such as levamis...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Yip D,Strickland AH,Karapetis CS,Hawkins CA,Harper PG

    更新日期:2000-06-01 00:00:00

  • Participation of adolescents with cancer in clinical trials.

    abstract::Adolescent patients with cancer reside in a "no-man's land" between the world of pediatric oncology and that of "adult" medical oncology. As compared to younger and older patients, adolescents and young adults are under-represented on clinical trials. This relative lack of participation in clinical protocols has been ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Ferrari A,Bleyer A

    更新日期:2007-11-01 00:00:00

  • Evidence-based use of taxanes in the adjuvant setting of breast cancer. A review of randomized phase III trials.

    abstract::Six major randomized clinical trials evaluating the role of taxanes in the adjuvant setting of breast cancer have demonstrated significant improvements in terms of efficacy in favour of the taxane treatment arm. In all cases, different anthracycline-based regimens were used as the control arm. Nevertheless, many clini...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Estévez LG,Muñoz M,Alvarez I,Fernández Y,García-Mata J,Ruiz-Borrego M,Tusquets I,Seguí MA,Rodríguez-Lescure A,Adrover E,Lluch A

    更新日期:2007-08-01 00:00:00

  • Alternative formulations of paclitaxel.

    abstract::Paclitaxel, a novel antitumour agent, is active clinically against advanced ovarian and breast cancer and under investigation for various other cancers. One of the problems associated with the intravenous administration of paclitaxel is its low solubility in water. The current pharmaceutical formulation consists of a ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Terwogt JM,Nuijen B,Huinink WW,Beijnen JH

    更新日期:1997-03-01 00:00:00

  • Prophylactic colony-stimulating factors in children receiving myelosuppressive chemotherapy: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The colony-stimulating factors (CSFs) are widely utilized to prevent neutropenic complications in both adults and children, but randomized controlled trials in the pediatric setting have reported varied results. A systematic review of the literature and meta-analysis were conducted to definitively assess the...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wittman B,Horan J,Lyman GH

    更新日期:2006-06-01 00:00:00

  • Estrogen receptor-negative progesterone receptor-positive breast cancer - "Nobody's land" or just an artifact?

    abstract::The estrogen receptor α (ER) and the progesterone receptor (PgR) are one of the most important prognostic and predictive immunohistochemical markers in breast cancer. Breast cancers may express various profiles of hormone receptors: ER(+)/PgR(+), ER(-)/PgR(-), ER(+)/PgR(-) and ER(-)/PgR(+). The existence of the latter...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Kunc M,Biernat W,Senkus-Konefka E

    更新日期:2018-06-01 00:00:00

  • Management of brain metastases in non-small cell lung cancer in the era of tyrosine kinase inhibitors.

    abstract::Lung cancer represents the most common cause of brain dissemination. Oncogene-addicted (EGFR- and ALK-positive) non-small cell lung cancers (NSCLCs) are characterized by a unique metastatic neurotropism resulting in a particularly high incidence of brain metastases. The goal of optimal brain metastases management is t...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Wrona A,Dziadziuszko R,Jassem J

    更新日期:2018-12-01 00:00:00

  • Swallowing dysfunction in head and neck cancer patients treated by radiotherapy: review and recommendations of the supportive task group of the Italian Association of Radiation Oncology.

    abstract:PURPOSE:Dysphagia is a debilitating complication in head and neck cancer patients (HNCPs) that may cause a high mortality rate for aspiration pneumonia. The aims of this paper were to summarize the normal swallowing mechanism focusing on its anatomo-physiology, to review the relevant literature in order to identify the...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Russi EG,Corvò R,Merlotti A,Alterio D,Franco P,Pergolizzi S,De Sanctis V,Ruo Redda MG,Ricardi U,Paiar F,Bonomo P,Merlano MC,Zurlo V,Chiesa F,Sanguineti G,Bernier J

    更新日期:2012-12-01 00:00:00

  • To what extent is alcohol consumption associated with breast cancer recurrence and second primary breast cancer?: A systematic review.

    abstract:BACKGROUND:The association between alcohol intake and breast cancer recurrence or development of second primary breast cancer in the survivor population is unclear. The aim of this systematic review was to evaluate the existing evidence to assess the extent to which alcohol consumption is associated with breast cancer ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Simapivapan P,Boltong A,Hodge A

    更新日期:2016-11-01 00:00:00

  • Personalizing therapy for older adults with acute myeloid leukemia: Role of geriatric assessment and genetic profiling.

    abstract::Acute myeloid leukemia (AML) presents therapeutic challenges in older adults because of high-risk leukemia biology conferring chemoresistance, and poor functional status resulting in increased therapy-related toxicities. Recent FDA approval of 8 new drugs for AML has increased therapeutic armamentarium and also provid...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Bhatt VR

    更新日期:2019-05-01 00:00:00

  • A systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy for localised and locally advanced prostate carcinoma.

    abstract:BACKGROUND:We performed a systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy (NHT) in localised and locally advanced prostate cancer to assess the effectiveness of this therapy. METHODS:We searched MEDLINE, The Cochrane Library, Science Citation Index, LILACS and SIGLE for randomi...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shelley MD,Kumar S,Wilt T,Staffurth J,Coles B,Mason MD

    更新日期:2009-02-01 00:00:00

  • Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.

    abstract::Cancer cells exhibit deregulation in multiple cellular signaling pathways. Therefore, treatments using specific agents that target only one pathway usually fail in cancer therapy. The combination treatments using chemotherapeutic agents with distinct molecular mechanisms are considered more promising for higher effica...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Sarkar FH,Li Y

    更新日期:2009-11-01 00:00:00

  • Gender and survival in malignant tumours.

    abstract:BACKGROUND:Epidemiological evidence supports the existence of a survival advantage for female patients with melanoma. This survival advantage often persists when other prognostic variables are taken into account. The basis for this female advantage or male disadvantage is not established although female sex steroids ca...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Molife R,Lorigan P,MacNeil S

    更新日期:2001-08-01 00:00:00

  • Opioid switching: a systematic and critical review.

    abstract::Cancer patients with pain may not respond to increasing doses of opioids because they develop adverse effects before achieving an acceptable analgesia, or the analgesic response is poor, despite a rapid dose escalation. Opioid switching may significantly improve the balance between analgesia and adverse effects. We co...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mercadante S,Bruera E

    更新日期:2006-06-01 00:00:00

  • Chemo-immunotherapy and chemo-adoptive immunotherapy of cancer.

    abstract::The chemo-immunotherapy (CIT) and chemo-adoptive immunotherapy (CAIT) regimens tested in the past decade are summarized. From them we have learned a great deal about the interactions between various chemotherapeutic agents, immune modulating agents and effector cells. The most commonly reported result in multi-modalit...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Gomez GG,Hutchison RB,Kruse CA

    更新日期:2001-12-01 00:00:00

  • The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target.

    abstract::Gastric cancer (GC) represents the fifth cause of cancer-related death worldwide. Molecular biology has become a central area of research in GC and there are currently at least three major classifications available to elucidate the mechanisms that drive GC oncogenesis. Further, tumor microenvironment seems to play a c...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Gambardella V,Castillo J,Tarazona N,Gimeno-Valiente F,Martínez-Ciarpaglini C,Cabeza-Segura M,Roselló S,Roda D,Huerta M,Cervantes A,Fleitas T

    更新日期:2020-06-01 00:00:00

  • Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review.

    abstract:BACKGROUND AND AIMS:The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients' own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Verbrugghe M,Verhaeghe S,Lauwaert K,Beeckman D,Van Hecke A

    更新日期:2013-10-01 00:00:00

  • Markers of bone turnover in prostate cancer.

    abstract::Prostate cancer is the most common malignancy in elderly men and is often associated with bone metastases. Although bone metastases are osteosclerotic, histological and biochemical studies clearly indicate an increase of both bone formation and bone resorption, providing the rational for using bisphosphonate as a pall...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Garnero P

    更新日期:2001-06-01 00:00:00

  • Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms.

    abstract::Targeted therapies have unique toxicity profiles. Common adverse events include rash, diarrhea, hypertension, hypothyroidism, proteinuria, depigmentation, and hepatotoxicity. Some of these toxicities are caused by on-target, mechanism-associated effects, which can be stratified as to whether or not the targets are rel...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Liu S,Kurzrock R

    更新日期:2014-08-01 00:00:00

  • Combating melanoma: the use of photodynamic therapy as a novel, adjuvant therapeutic tool.

    abstract::Metastatic malignant melanoma remains one of the most dreaded skin cancers worldwide. Numerous factors contribute to its resistance to hosts of treatment regimes and despite significant scientific advances over the last decade in the field of chemotherapeutics and melanocytic targets, there still remains the need for ...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Davids LM,Kleemann B

    更新日期:2011-10-01 00:00:00

  • Cellular immunotherapy in breast cancer: The quest for consistent biomarkers.

    abstract::Breast cancer is the most common malignancy in women worldwide, with a relatively high proportion of patients experiencing resistance to standard treatments. Cellular immunotherapy (CI), which is based on the extraction, modification, and re-infusion of the patient's immune cells, is showing promising results in these...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Venetis K,Invernizzi M,Sajjadi E,Curigliano G,Fusco N

    更新日期:2020-11-01 00:00:00

  • Finding the right dose of fulvestrant in breast cancer.

    abstract::Fulvestrant is a selective estrogen receptor downregulator, behaving as a complete antagonist. It was initially approved, at a dose of 250 mg, to treat hormone dependant breast cancer in second line setting. However, a series of pharmacological and pre-clinical studies have suggested that a higher dose of 500 mg may b...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Estévez L,Alvarez I,Tusquets I,Seguí MA,Muñoz M,Fernández Y,Lluch A

    更新日期:2013-04-01 00:00:00

  • Oncological implications of hypoxia inducible factor-1alpha (HIF-1alpha) expression.

    abstract::Solid tumours contain regions of hypoxia, which may be a prognostic indicator and determinant of malignant progression, metastatic development and chemoradio-resistance. The degree of intra-tumoural hypoxia has been shown to be positively correlated with the expression of the transcription factor hypoxia-inducible fac...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: O'Donnell JL,Joyce MR,Shannon AM,Harmey J,Geraghty J,Bouchier-Hayes D

    更新日期:2006-10-01 00:00:00

  • Developments in the systemic treatment of metastatic cervical cancer.

    abstract::Despite the available prevention and early detection strategies, advanced squamous-cell carcinoma of the uterine cervix remains a major concern for public health. Systemic treatment with cisplatin, either in combination with external beam irradiation for locally advanced disease, or as monotherapy for recurrent/metast...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Mountzios G,Soultati A,Pectasides D,Pectasides E,Dimopoulos MA,Papadimitriou CA

    更新日期:2013-08-01 00:00:00

  • Megestrol acetate: clinical experience.

    abstract::The use of megestrol acetate in treatment of malignancy (endometrial carcinoma, ovarian cancer, prostate cancer, breast cancer, renal cell carcinoma, malignant melanoma), endometrial hyperplasia, benign prostatic hypertrophy, contraception, anorexia, cachexia and weight loss is reviewed, concluding with a toxicity pro...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Schacter L,Rozencweig M,Canetta R,Kelley S,Nicaise C,Smaldone L

    更新日期:1989-03-01 00:00:00

  • PD-1 and PD-L1 blockade in gastrointestinal malignancies.

    abstract::Immunotherapy represents a major breakthrough in cancer therapy in recent years. Immune-checkpoint blockade using PD-1 and PD-L1 antibodies appears to be one of the most promising immunotherapy approaches. Immunotherapy differs from conventional cancer treatment because of its ability to produce durable responses in s...

    journal_title:Cancer treatment reviews

    pub_type: 杂志文章,评审


    authors: Lote H,Cafferkey C,Chau I

    更新日期:2015-12-01 00:00:00