Targeting uPA/uPAR in prostate cancer.

Abstract:

:Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases). The invasive ability of tumour cells plays a key role in CaP metastasis and is a major cause of treatment failure. Urokinase plasminogen activator (uPA) and its receptor (uPAR)-mediated signalling have been implicated in tumour cell invasion, survival, and metastasis in a variety of cancers including CaP. Both uPA and uPAR are expressed at much higher levels in CaP tissues than in benign and normal prostate tissues. They are used as diagnostic markers as well as therapeutic targets due to their aberrant and unique expression pattern during cancer progression. Current therapeutic options for patients with metastatic hormone-refractory CaP (HRPC) are very limited. Therefore, much effort is currently being directed toward targeting aberrant uPA or uPAR activity in CaP. This review summarizes some important new findings supporting the role of uPA/uPAR in CaP progression and establishing the potential therapeutic efficacy of uPA/uPAR-targeted therapies in CaP.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Li Y,Cozzi PJ

doi

10.1016/j.ctrv.2007.06.003

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

521-7

issue

6

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(07)00076-X

journal_volume

33

pub_type

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