Abstract：
:Differentiated thyroid cancer is the most common endocrine malignancy, and its incidence has been rising rapidly over the past 10 years. Although most patients with this disease have an excellent prognosis, a subset develops a more aggressive disease phenotype refractory to conventional therapies. Until recently, there was no effective therapy for these patients. With increasing knowledge of the molecular pathogenesis of thyroid cancer, novel targeted therapies are being developed for this group of patients. Sorafenib and lenvatinib, small-molecule multikinase inhibitors, were approved for the treatment of progressive, symptomatic, radioactive iodine refractory, advanced differentiated thyroid cancer in 2013 and 2015, respectively. This represents a major innovation in the therapy of patients with advanced thyroid cancer. However, these therapies still have many limitations and further research needs to be pursued with the ultimate goal of providing safe and effective personalized therapy for patients with advanced thyroid cancer.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Carneiro RM,Carneiro BA,Agulnik M,Kopp PA,Giles FJdoi
10.1016/j.ctrv.2015.06.002subject
Has Abstractpub_date
2015-09-01 00:00:00pages
690-8issue
8eissn
0305-7372issn
1532-1967pii
S0305-7372(15)00124-3journal_volume
41pub_type
杂志文章,评审abstract：:Borderline ovarian tumours (BOT) may occur in young women and have an excellent survival rate. Therefore, there is the obligation to put emphasis on fertility preservation in affected women. On the other hand, it has also been underlined that the disease should be managed with caution because these tumours can relapse...
journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2009.02.005
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abstract：BACKGROUND:We performed a systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy (NHT) in localised and locally advanced prostate cancer to assess the effectiveness of this therapy. METHODS:We searched MEDLINE, The Cochrane Library, Science Citation Index, LILACS and SIGLE for randomi...
journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2013.10.001
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2016.09.010
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2013.09.013
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2012.04.002
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ctrv.2013.02.001
更新日期：2013-11-01 00:00:00
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2012.09.007
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ctrv.2017.04.005
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2016.09.018
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2011.05.002
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2009.06.001
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ctrv.2006.03.001
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2005.05.007
更新日期：2005-10-01 00:00:00
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/s0305-7372(03)00003-3
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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abstract：:The use of agents able to modulate the immune system to induce or potentiate its anti-tumour activity is not a new strategy in oncology. However, the development of new agents such as immune checkpoint inhibitors has achieved unprecedented efficacy results in a wide variety of tumours, dramatically changing the landsc...
journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章
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更新日期：1983-09-01 00:00:00
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journal_title：Cancer treatment reviews
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doi：10.1016/j.ctrv.2004.12.007
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