Update on capecitabine alone and in combination regimens in colorectal cancer patients.

abstract：:In the last few years, several drugs targeting signalling proteins critical for melanoma entered clinical evaluation. In 2011 vemurafenib (Zelboraf®, F. Hoffman-La Roche Ltd.) was approved for BRAF V600-positive melanoma and showed high overall response rates (48-53%). However recent results from a phase II clinical t...

journal_title：Cancer treatment reviews

authors： Nijenhuis CM,Haanen JB,Schellens JH,Beijnen JH

更新日期：2013-06-01 00:00:00

abstract：:Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers and remains a challenge in oncology. In 1997, gemcitabine became the standard of care in metastatic setting. In the last decades, despite a number of clinical trials assessing novel cytotoxic agents and cell signaling inhibitors, overall sur...

journal_title：Cancer treatment reviews

authors： El Maalouf G,Le Tourneau C,Batty GN,Faivre S,Raymond E

更新日期：2009-04-01 00:00:00

abstract：:Although surgery provides excellent control for localized prostate cancer, pathologic examination of more than one-third of specimens will reveal positive surgical margins, seminal vesicle invasion, and/or extracapsular extension, thus putting these patients at increased risk of cancer recurrence. "Adjuvant" radiother...

journal_title：Cancer treatment reviews

authors： Raldow A,Hamstra DA,Kim SN,Yu JB

更新日期：2011-04-01 00:00:00

abstract：:Aflibercept, also known as vascular endothelial growth factor (VEGF)-Trap, is a recombinant, decoy receptor fusion protein, rationally designed to block angiogenesis by targeting not only all forms of VEGF-A, but also VEGF-B and placental growth factor. It inhibits VEGF-induced angiogenesis in preclinical models. In t...

journal_title：Cancer treatment reviews

authors： Gaya A,Tse V

更新日期：2012-08-01 00:00:00

abstract：:Metastatic colorectal cancer (CRC) is most frequently seen in the liver. Resection of metastases remains the treatment of choice; however, the majority of patients are ineligible for surgery due to unfavorable location, size, or number of metastases; insufficient liver reserve; or extrahepatic disease. The activity of...

journal_title：Cancer treatment reviews

authors： Pozzo C,Barone C,Kemeny NE

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Surgery is the only curative treatment for primary cutaneous melanoma, therefore it is important to determine excision margins that minimise risk of local recurrence, distant recurrence and death. METHODS:MEDLINE, EMBASE and Cochrane CENTRAL were searched from 2009 to 2015. Inclusion criteria were: populati...

journal_title：Cancer treatment reviews

authors： Wheatley K,Wilson JS,Gaunt P,Marsden JR

更新日期：2016-01-01 00:00:00

abstract：:Whereas first-line chemotherapy (CT) with single-agent gemcitabine or gemcitabine-based combinations provides a proven benefit in patients with locally advanced or metastatic pancreatic cancer (PC), the role of salvage CT after gemcitabine-failure is not well-established and to date no regimen has emerged as preferred...

journal_title：Cancer treatment reviews

authors： Custodio A,Puente J,Sastre J,Díaz-Rubio E

更新日期：2009-12-01 00:00:00

abstract：:Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with "cisplatin-resistant" cancer. We identified 25 pre-clinical cell models ...

journal_title：Cancer treatment reviews

authors： Stordal B,Pavlakis N,Davey R

更新日期：2007-06-01 00:00:00

abstract：:Approximately 5-10% of breast cancer cases might be inheritable, up to 30% of which are due to BRCA1/2 mutations. During the past few years and thanks to technology evolution, we have been witnesses of an intensive search of additional genes with similar characteristics, under the premise that successful gene discover...

journal_title：Cancer treatment reviews

authors： Economopoulou P,Dimitriadis G,Psyrri A

更新日期：2015-01-01 00:00:00

abstract：:Glioblastomas are the most common malignant primary intrinsic brain tumors. Their incidence increases with age, and males are more often affected. First-line management includes maximum safe surgical resection followed by involved-field radiotherapy plus concomitant and six cycles of maintenance temozolomide chemother...

journal_title：Cancer treatment reviews

authors： Weller M,Le Rhun E

更新日期：2020-07-01 00:00:00

abstract：:Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other pa...

journal_title：Cancer treatment reviews

authors： Tokunaga R,Zhang W,Naseem M,Puccini A,Berger MD,Soni S,McSkane M,Baba H,Lenz HJ

更新日期：2018-02-01 00:00:00

abstract：:Infertility is a common and distressing late-effect of cancer treatment. Whist sperm banking for post-pubertal males and embryo freezing for women (who are in a stable relationship at the time of treatment) are highly successful fertility preservation strategies, for females without a partner (including young and pre-...

journal_title：Cancer treatment reviews

authors： Pacey AA

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Different modalities of treatment in early laryngeal cancer lead to equivalent oncological outcomes. Hence this systematic review was undertaken to synthesise the key oncological outcomes following primary open partial laryngectomy for laryngeal cancer. METHODS:A systematic review of the English literature ...

journal_title：Cancer treatment reviews

authors： Thomas L,Drinnan M,Natesh B,Mehanna H,Jones T,Paleri V

更新日期：2012-05-01 00:00:00

abstract：:While chemotherapy has been the standard of care for patients with advanced non-small cell lung cancer (NSCLC), efforts have shifted toward evaluating novel targeted agents in an attempt to improve outcome. These targeted agents are directed toward key components in several signalling pathways such as vascular endothe...

journal_title：Cancer treatment reviews

authors： Belani CP,Goss G,Blumenschein G Jr

更新日期：2012-05-01 00:00:00

abstract：:During the last decade, important progress has been made in the surgical treatment of malignant liver tumors in children. For hepatoblastoma, there is a general consensus for combining surgical resection with neoadjuvant (and adjuvant) chemotherapy. Long-term disease-free survival of around 85-90% can be achieved for ...

journal_title：Cancer treatment reviews

authors： Otte JB

更新日期：2010-06-01 00:00:00

abstract：:The term Unfit refers to older cancer patients not amenable with standard treatment and needing therefore a modified or attenuated treatment or also not deserving an active therapeutic approach. To determine whether an old patient is Unfit a Multidimensional Geriatric Evaluation is needed, but to spare time, shortened...

journal_title：Cancer treatment reviews

authors： Monfardini S

更新日期：2009-10-01 00:00:00

abstract：:Haplo-identical transplant is being increasingly used in patients who do not have a readily available matched related or unrelated donor. Post-transplant cyclophosphamide's use due to its simplicity and documented efficacy has made this approach readily employable across diverse transplant centres across the globe. Th...

journal_title：Cancer treatment reviews

authors： Patil S,Potter V,Mohty M

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Neoadjuvant chemotherapy followed by surgery (NACT + S) has been compared with definitive chemoradiothherapy (CRT) in randomized clinical trials (RCTs) in stage IB2, IIA and IIB cervical cancer (1994 Figo stage). Our aim was to evaluate efficacy and toxicity of NACT + S and CRT and identify differences in clini...

journal_title：Cancer treatment reviews

authors： Marchetti C,Fagotti A,Tombolini V,Scambia G,De Felice F

更新日期：2020-02-01 00:00:00

abstract：:Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues and displays a wide range of biological activities. In oncology, galectin-1 plays a pivotal role in tumor growth and in the multistep proces...

journal_title：Cancer treatment reviews

authors： Astorgues-Xerri L,Riveiro ME,Tijeras-Raballand A,Serova M,Neuzillet C,Albert S,Raymond E,Faivre S

更新日期：2014-03-01 00:00:00

abstract：:Despite recent progress in the diagnostic and therapeutic approaches to the management of women with breast cancer, at least one third of these women will ultimately die from their disease. This resulted in a new focus on breast cancer prevention, especially for the woman designed as "high-risk". The continuing challe...

journal_title：Cancer treatment reviews

authors： Sakorafas GH

更新日期：2003-04-01 00:00:00

abstract：:Tumour budding reflects a detachment of tumour cells at the invasive front of carcinomas and is presumed to be an early step in the metastatic process. Tumour budding has received some attention in colorectal cancer as it has been proposed as an additional prognostic factor in colorectal cancer that may stratify patie...

journal_title：Cancer treatment reviews

authors： van Wyk HC,Park J,Roxburgh C,Horgan P,Foulis A,McMillan DC

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To evaluate the existing evidence regarding the long-term risk of cardiovascular disease (CVD) after radiotherapy for childhood cancer. PATIENTS AND METHODS:MEDLINE and EMBASE were searched for articles reporting on radiation-induced CVD after childhood cancer published between 1966 and October 2002. Informati...

journal_title：Cancer treatment reviews

authors： van der Pal HJ,van Dalen EC,Kremer LC,Bakker PJ,van Leeuwen FE

更新日期：2005-05-01 00:00:00

abstract：:Antiangiogenic agents (AAs) have reported grater efficacy compared to interferon. Despite these advances, radiological complete response to therapy is rare. We meta-analyzed the incidence of complete response in patients treated with AAs and in controls in main randomized clinical trials for first-line therapy in meta...

journal_title：Cancer treatment reviews

authors： Iacovelli R,Alesini D,Palazzo A,Trenta P,Santoni M,De Marchis L,Cascinu S,Naso G,Cortesi E

更新日期：2014-03-01 00:00:00

abstract：:Vinorelbine is a semi-synthetic vinca alkaloid that has been shown active in many tumour types and is currently registered for the treatment of advanced breast cancer (ABC) and non-small cell lung cancer (NSCLC). This agent has a generally favourable safety profile, and may be suitable for use in special populations s...

journal_title：Cancer treatment reviews

authors： Mano M

更新日期：2006-04-01 00:00:00

abstract：:There has been much progress in the understanding of the relationship between the immune system and colorectal cancer. This has led to the use of immunomodulatory therapy in the adjuvant and palliative treatment of the condition. Although attempts at the use of non-specific immunomodulation with agents such as levamis...

journal_title：Cancer treatment reviews

authors： Yip D,Strickland AH,Karapetis CS,Hawkins CA,Harper PG

更新日期：2000-06-01 00:00:00

abstract：:From a theoretical viewpoint, intraperitoneal therapy (IP) in patients with ovarian cancer, a malignancy which remains mainly confined to the peritoneal cavity, is logical. Over the past decades this approach has evolved into a therapeutic strategy for a selected group of patients. Data available at present suggest a ...

journal_title：Cancer treatment reviews

authors： Hofstra LS,de Vries EG,Mulder NH,Willemse PH

更新日期：2000-04-01 00:00:00

abstract：:Peptide receptor radionuclide therapy (PRRT) is an important therapeutic option for somatostatin receptor (SSTR) positive metastatic and/or inoperable neuroendocrine tumours (NETs). However, in patients with poorly controlled carcinoid syndrome, it may lead to an acute flare of carcinoid symptoms or even carcinoid cri...

journal_title：Cancer treatment reviews

authors： Tapia Rico G,Li M,Pavlakis N,Cehic G,Price TJ

更新日期：2018-05-01 00:00:00

abstract：:Despite the initially high response rate to standard front-line debulking surgery followed by platinum-based chemotherapy, the relapse rate in ovarian cancer is high and many patients will recur within 6 months of completing platinum based treatment. These patients may still require further chemotherapy despite being ...

journal_title：Cancer treatment reviews

authors： Pinato DJ,Graham J,Gabra H,Sharma R

更新日期：2013-04-01 00:00:00

abstract：:The estrogen receptor α (ER) and the progesterone receptor (PgR) are one of the most important prognostic and predictive immunohistochemical markers in breast cancer. Breast cancers may express various profiles of hormone receptors: ER(+)/PgR(+), ER(-)/PgR(-), ER(+)/PgR(-) and ER(-)/PgR(+). The existence of the latter...

journal_title：Cancer treatment reviews

authors： Kunc M,Biernat W,Senkus-Konefka E

更新日期：2018-06-01 00:00:00

abstract：:Pancreatic cancer is a disease with a high mortality rate and short survival, as a result of the high incidence of metastatic disease at diagnosis, the fulminant clinical course and the lack of successful therapeutic strategies. The administration of chemotherapeutic agents for the treatment of advanced disease has fa...

journal_title：Cancer treatment reviews

authors： Pliarchopoulou K,Pectasides D

更新日期：2009-08-01 00:00:00