Abstract：
:Malignant Pleural Mesothelioma (MPM) is an aggressive tumour with poor prognosis and increasing incidence in industrialized countries because of the previous widespread exposure to asbestos fibres and to the long lag period from time of exposure and the diagnosis of the disease. MPM shows high refractoriety to systemic treatment, single-modality treatment was generally ineffective and did not achieve higher results than supportive care. The incidence of local and distant recurrences after surgery remains high and that was the reason for many centres to perform combined treatments. In the attempt of reducing the incidence of local recurrences, a multimodality approach with surgery followed by adjuvant radiotherapy was explored. Extrapleural pneumonectomy (EPP) allows higher doses of radiotherapy to the whole hemithorax by avoiding pulmonary toxicity and the results of this approach is a significant reduction of loco-regional relapses; although, extrathoracic metastasis represent a major problem in the management of the disease because of the impact on overall survival. The success with surgical resection after neoadjuvant chemotherapy in stage IIIA lung cancer has been the impetus for several groups to apply this strategy in MPM aiming at reducing the incidence of distant relapse after surgery. Platinum-based chemotherapy plus gemcitabine or pemetrexed for 3-4 cycles followed by surgery and postoperative high-dose radiotherapy showed the best results in terms of overall and progression free survival. This review will focus on the main clinical studies and overview the results of different chemotherapy regimens in the neoadjuvant treatment of MPM.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Pasello G,Ceresoli GL,Favaretto Adoi
10.1016/j.ctrv.2012.03.001subject
Has Abstractpub_date
2013-02-01 00:00:00pages
10-7issue
1eissn
0305-7372issn
1532-1967pii
S0305-7372(12)00052-7journal_volume
39pub_type
杂志文章,评审abstract：BACKGROUND:Data on the comparative efficacy of fulvestrant and other endocrine treatments are inconsistent. Clinical markers predictive of greater benefit from fulvestrant compared to the alternate endocrine agents have not been identified. METHODS:We searched the literature from inception to May 2015, using MEDLINE, ...
journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ctrv.2016.02.004
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,meta分析,评审
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
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doi：10.1016/j.ctrv.2012.12.006
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2008.09.007
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journal_title：Cancer treatment reviews
pub_type： 杂志文章,评审
doi：10.1016/j.ctrv.2007.01.009
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journal_title：Cancer treatment reviews
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pub_type： 杂志文章,评审
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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journal_title：Cancer treatment reviews
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章,评审
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