Abstract：
:With increasing numbers of cancer survivors, attention has been drawn to long-term complications of curative cancer treatment, including a range of metabolic disorders. These metabolic disorders often resemble the components of the so-called metabolic syndrome, or syndrome X, which is an important risk factor for the development of cardiovascular disease. The mechanisms behind the development of metabolic disorders in cancer survivors have not been fully elucidated. However, association studies in the general population have demonstrated correlations between the components of the metabolic syndrome on the one hand and hormonal deficiencies, hypomagnesaemia, and endothelial dysfunction on the other. These latter disorders are regularly reported following curative cancer treatment and could, therefore, be important aetiologic factors in the development of the metabolic syndrome in cancer survivors. This review discusses data on the associations between the metabolic syndrome and treatment-related complications in cancer survivors and possibilities for preventive measures.
journal_name
Cancer Treat Revjournal_title
Cancer treatment reviewsauthors
Nuver J,Smit AJ,Postma A,Sleijfer DT,Gietema JAdoi
10.1016/s0305-7372(02)00038-5keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
195-214issue
4eissn
0305-7372issn
1532-1967pii
S0305737202000385journal_volume
28pub_type
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