Stereotactic radiosurgery and hypofractionated stereotactic radiotherapy: normal tissue dose constraints of the central nervous system.

Abstract:

:Single-fraction stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (SRT) are radiation planning and delivery techniques used for the treatment of intracranial and spine/spinal cord tumors and targets. For cranial SRS and SRT, critical normal tissues/structures include the brainstem, cranial nerves, cochlea and normal brain parenchyma. For spine SRS/SRT, critical normal tissues/structures include the spinal cord, cauda equina as well as neighboring organs. This paper reviews clinical studies investigating central nervous system dose tolerances after cranial or spinal SRS/SRT. The impact of dose, volume, fractionation, and other relevant clinic-pathologic variables are discussed, as are limitations of the published data.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Milano MT,Usuki KY,Walter KA,Clark D,Schell MC

doi

10.1016/j.ctrv.2011.04.004

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

567-78

issue

7

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(11)00066-1

journal_volume

37

pub_type

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