FLCN is a novel Rab11A-interacting protein that is involved in the Rab11A-mediated recycling transport.

abstract：:The path that RNA takes through nuclear pores was mapped using two high-resolution techniques. Unexpectedly, no RNA in HL60 cells was detected by immunogold labelling in the central axis of the pore complex on its way to the transporter at the nuclear membrane; instead, it was distributed around the sides, apparently ...

journal_title：Journal of cell science

authors： Iborra FJ,Jackson DA,Cook PR

更新日期：2000-01-01 00:00:00

abstract：:Transglutaminases (TGases) are enzymes which catalyze cross-link formation between glutamine residues and lysine residues in substrate proteins. In the present study, we report for the first time that a representative enzyme, blood coagulation factor XIIIa (FXIIIa), is capable of mediating adhesion of various cells. W...

journal_title：Journal of cell science

authors： Ueki S,Takagi J,Saito Y

更新日期：1996-11-01 00:00:00

abstract：:Sorting endosomes (SEs) are the regulatory hubs for sorting cargo to multiple organelles, including lysosome-related organelles, such as melanosomes in melanocytes. In parallel, melanosome biogenesis is initiated from SEs with the processing and sequential transport of melanocyte-specific proteins toward maturing mela...

journal_title：Journal of cell science

authors： Nag S,Rani S,Mahanty S,Bissig C,Arora P,Azevedo C,Saiardi A,van der Sluijs P,Delevoye C,van Niel G,Raposo G,Setty SRG

更新日期：2018-09-20 00:00:00

abstract：:Members of the bimC family of kinesin related proteins (KRPs) play vital roles in the formation and function of the mitotic spindle. Although they share little amino acid homology outside the highly conserved microtubule motor domain, several family members do contain a 'bimC box', a sequence motif around a p34(cdc2) ...

journal_title：Journal of cell science

authors： Drummond DR,Hagan IM

更新日期：1998-04-01 00:00:00

abstract：:Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain. Here, we identify a novel role for aquaporin-4 in astroglial cell migration, as occurs during glial scar formation. Astroglia cultured from the neocortex of aquaporin...

journal_title：Journal of cell science

authors： Saadoun S,Papadopoulos MC,Watanabe H,Yan D,Manley GT,Verkman AS

更新日期：2005-12-15 00:00:00

abstract：:Septins have been shown to play important roles in cytokinesis in diverse organisms ranging from yeast to mammals. In this study, we show that both the unc-59 and unc-61 loci encode Caenorhabditis elegans septins. Genomic database searches indicate that unc-59 and unc-61 are probably the only septin genes in the C. el...

journal_title：Journal of cell science

authors： Nguyen TQ,Sawa H,Okano H,White JG

更新日期：2000-11-01 00:00:00

abstract：:Mammalian Delta9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the endoplasmic reticulum (ER). It is a short-lived multispanning ER membrane protein, reported to be degraded by the ubiquitin-proteasome-independent pathway. We have examined SCD1 protein degradat...

journal_title：Journal of cell science

authors： Kato H,Sakaki K,Mihara K

更新日期：2006-06-01 00:00:00

abstract：:Hepatocyte growth factor, also known as scatter factor, is a pleiotropic cytokine, which stimulates cell motility, invasion, proliferation, survival and morphogenesis, and induces the expression of specific genes by activating its receptor tyrosine kinase. In this work we have isolated, characterized and used as agoni...

journal_title：Journal of cell science

authors： Prat M,Crepaldi T,Pennacchietti S,Bussolino F,Comoglio PM

更新日期：1998-01-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic human disease, with around 12.5 million people affected worldwide. ADPKD results from mutations in either PKD1 or PKD2, which encode the atypical G-protein coupled receptor polycystin-1 (PC1) and the transient receptor potential channel ...

journal_title：Journal of cell science

authors： Tilley FC,Gallon M,Luo C,Danson CM,Zhou J,Cullen PJ

更新日期：2018-06-06 00:00:00

abstract：:Vertebrate oocytes proceed through the first and the second meiotic division without an intervening S-phase to become haploid. Although DNA replication does not take place, unfertilized oocytes acquire the competence to replicate DNA one hour after the first meiotic division by accumulating an essential factor of the ...

journal_title：Journal of cell science

authors： Daldello EM,Le T,Poulhe R,Jessus C,Haccard O,Dupré A

更新日期：2015-07-15 00:00:00

abstract：:Thrombospondin-1 (TSP-1) and the highly related protein thrombospondin-2 (TSP-2) are trimeric extracellular molecules that have complex roles in wound healing, angiogenesis and matrix organisation. At the cellular level, TSP-1 supports cell adhesion and migration by the organisation of fascin spike cytoskeletal struct...

journal_title：Journal of cell science

authors： Anilkumar N,Annis DS,Mosher DF,Adams JC

更新日期：2002-06-01 00:00:00

abstract：:Blocking expression of EhCaBP1, a calmodulin-like, four EF-hand protein from the protozoan parasite Entamoeba histolytica, resulted in inhibition of cellular proliferation. In this paper we report that EhCaBP1 is involved in dynamic changes of the actin cytoskeleton. Both endocytosis and phagocytosis were severely imp...

journal_title：Journal of cell science

authors： Sahoo N,Labruyère E,Bhattacharya S,Sen P,Guillén N,Bhattacharya A

更新日期：2004-07-15 00:00:00

abstract：:Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C is more nucleoplas...

journal_title：Journal of cell science

authors： West G,Gullmets J,Virtanen L,Li SP,Keinänen A,Shimi T,Mauermann M,Heliö T,Kaartinen M,Ollila L,Kuusisto J,Eriksson JE,Goldman RD,Herrmann H,Taimen P

更新日期：2016-07-15 00:00:00

abstract：:The asparaginyl hydroxylase factor inhibiting HIF-1 (FIH-1) is an important suppressor of hypoxia-inducible factor (HIF) activity. In addition to HIF-α, FIH-1 was previously shown to hydroxylate other substrates within a highly conserved protein interaction domain, termed the ankyrin repeat domain (ARD). However, to d...

journal_title：Journal of cell science

authors： Janke K,Brockmeier U,Kuhlmann K,Eisenacher M,Nolde J,Meyer HE,Mairbäurl H,Metzen E

更新日期：2013-06-15 00:00:00

abstract：:We previously reported that integrin alpha 3 beta 1 mediates epidermal intercellular adhesion as well as cell-substrate adhesion. P1B5, an anti-alpha 3 beta 1 specific monoclonal antibody, is a potent in vitro trigger of epidermal cell-cell adhesion and an inhibitor of cell-substrate adhesion. We now show that P1B5 sp...

journal_title：Journal of cell science

authors： Symington BE,Carter WG

更新日期：1995-02-01 00:00:00

abstract：:We have reported earlier that the polyphosphoinositide messenger system may control mitosis in sea urchin eggs. Besides phospholipase C activation and its second messengers, phosphatidylinositol (PI) 3-kinase has been proposed to affect a wide variety of cellular processes in other cellular systems. Therefore, we have...

journal_title：Journal of cell science

authors： De Nadai C,Huitorel P,Chiri S,Ciapa B

更新日期：1998-09-01 00:00:00

abstract：:p97 (CDC-48 in Caenorhabditis elegans) is a ubiquitin-selective AAA (ATPases associated with diverse cellular activities) chaperone and its key function is to disassemble protein complexes. p97 functions in diverse cellular processes including endoplasmic reticulum (ER)-associated degradation, membrane fusion, and mei...

journal_title：Journal of cell science

authors： Sasagawa Y,Otani M,Higashitani N,Higashitani A,Sato K,Ogura T,Yamanaka K

更新日期：2009-10-15 00:00:00

abstract：:Mastigonemes are hair-like projections on the flagella of various kinds of lower eukaryotes. We obtained a monoclonal antibody (mAb-MAST1) to mastigonemes of Chlamydomonas reinhardtii, and found that it reacts with a single flagellar glycoprotein of about 230 kDa. Interestingly, immunofluorescence microscopy demonstra...

journal_title：Journal of cell science

authors： Nakamura S,Tanaka G,Maeda T,Kamiya R,Matsunaga T,Nikaido O

更新日期：1996-01-01 00:00:00

abstract：:Two variants (74AD and 74FL) established from rat ascites hepatoma AH7974 were examined for the production of glycosaminoglycans in culture. There was no difference between the adhesive (74AD) and the floating (74FL) variants in quantity of glycosaminoglycans produced by their cultivation in minimum essential medium s...

journal_title：Journal of cell science

authors： Kimura A,Kawaguchi T,Ono T,Sakuma A,Yokoya Y,Kochi H,Nakamura K

更新日期：1988-08-01 00:00:00

abstract：:Mutation of the p53 gene is a common occurrence in human breast cancers but is by no means universal. However, even in tumours where the gene is not mutated altered levels of p53 protein are often detected. This is also observed in cell lines derived from human breast cancers. By transfecting such cell lines containin...

journal_title：Journal of cell science

authors： Vojtĕsek B,Lane DP

更新日期：1993-07-01 00:00:00

abstract：:Epithelial cells cultured on type I collagen gels adopt a typical apical--basal polarity and undergo differentiation. We have compared the behaviour of chick embryo retinal pigmented epithelial (RPE) cells on collagen and on plastic with and without gelatin coats. RPE cell proliferation was similar on all three substr...

journal_title：Journal of cell science

authors： Docherty RJ,Forrester JV,Lackie JM

更新日期：1987-04-01 00:00:00

abstract：:Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin-dependent manner. A conserved cortical protein complex, composed of LGN (also known as GPSM2), NuMA (also known as NUMA1) and dynein-dynactin, plays a key role...

journal_title：Journal of cell science

authors： Kschonsak YT,Hoffmann I

更新日期：2018-05-21 00:00:00

abstract：:When cultured cerebellar macroneurons develop attached to a laminin-containing substrate or after the acute addition of laminin to the tissue culture medium, there is an acceleration in the rate and extent of axonal elongation. Furthermore, laminin is capable of inducing axonal formation and microtubule stabilization ...

journal_title：Journal of cell science

authors： DiTella MC,Feiguin F,Carri N,Kosik KS,Cáceres A

更新日期：1996-02-01 00:00:00

abstract：:We have isolated a fourth myosin gene (MYO4) in yeast (Saccharomyces cerevisiae). MYO4 encodes a approximately 170 kDa (1471 amino acid) class V myosin, using the classification devised by Cheney et al. (1993a; Cell Motil. Cytoskel. 24, 215-223); the motor domain is followed by a neck region containing six putative ca...

journal_title：Journal of cell science

authors： Haarer BK,Petzold A,Lillie SH,Brown SS

更新日期：1994-04-01 00:00:00

abstract：:Class-V myosins are two-headed actin-based mechanoenzymes that function in the transport and subcellular localization of organelles and possibly in the outgrowth of cellular processes. To determine which domains of myosin-V are involved in intracellular localization of this motor protein, we have expressed fusions of ...

journal_title：Journal of cell science

authors： Tsakraklides V,Krogh K,Wang L,Bizario JC,Larson RE,Espreafico EM,Wolenski JS

更新日期：1999-09-01 00:00:00

abstract：:Barrier junctions prevent pathogen invasion and restrict paracellular leakage across epithelial sheets. To understand how one barrier junction, the septate junction (SJ), is regulated in vivo, we used fluorescence recovery after photobleaching (FRAP) to examine SJ protein dynamics in Drosophila. Most SJ-associated pro...

journal_title：Journal of cell science

authors： Oshima K,Fehon RG

更新日期：2011-08-15 00:00:00

abstract：:Changes in cellular behavior that cause epithelial cells to lose adhesiveness, acquire a motile invasive phenotype and metastasize to secondary sites are complex and poorly understood. Molecules that normally function to integrate adhesive spatial information with cytoskeleton dynamics and membrane trafficking probabl...

journal_title：Journal of cell science

authors： Spiczka KS,Yeaman C

更新日期：2008-09-01 00:00:00

abstract：:The molecular mechanisms regulating skeletal muscle regeneration and differentiation are not well understood. We analyzed the expression of connexins (Cxs) 40, 43 and 45 in normal and regenerating tibialis anterior muscle and in primary cultures of differentiating myoblasts in adult and newborn mice, respectively. Cxs...

journal_title：Journal of cell science

authors： Araya R,Eckardt D,Maxeiner S,Krüger O,Theis M,Willecke K,Sáez JC

更新日期：2005-01-01 00:00:00

abstract：:Specific degradation of proteins is essential for virtually all cellular processes and is carried out predominantly by the proteasome. The proteasome is important for clearance of damaged cellular proteins. Damaged proteins accumulate over time and excess damaged proteins can aggregate and induce the death of old cell...

journal_title：Journal of cell science

authors： van Deventer S,Menendez-Benito V,van Leeuwen F,Neefjes J

更新日期：2015-01-01 00:00:00

abstract：:RAS isoforms have been proposed to exhibit differing biological outputs due to differences in their relative occupancy of cellular organelles and signalling microdomains. The membrane binding and targeting motifs of RAS are encoded by the C-terminal hypervariable region (HVR), and the precise localisation depends upon...

journal_title：Journal of cell science

authors： Laude AJ,Prior IA

更新日期：2008-02-15 00:00:00