A comprehensive review of circRNA: from purification and identification to disease marker potential.

abstract：Background:Type 2 diabetes mellitus (T2DM) had been reported to be associated with tendinopathy. However, the underlying mechanisms of diabetic tendinopathy still remain largely to be discovered. The purpose of this study was to develop insulin resistance (IR) model on primary human tenocytes (hTeno) culture with tumou...

journal_title：PeerJ

authors： Tan HY,Tan SL,Teo SH,Roebuck MM,Frostick SP,Kamarul T

更新日期：2020-06-08 00:00:00

abstract：:Grouping large genomic fragments assembled from shotgun metagenomic sequences to deconvolute complex microbial communities, or metagenome binning, enables the study of individual organisms and their interactions. Because of the complex nature of these communities, existing metagenome binning methods often miss a large...

journal_title：PeerJ

authors： Kang DD,Froula J,Egan R,Wang Z

更新日期：2015-08-27 00:00:00

abstract：:A range of diseases is associated with amyloid fibril formation. Despite different proteins being responsible for each disease, all of them share similar features including beta-sheet-rich secondary structure and fibril-like protein aggregates. A number of proteins can form amyloid-like fibrils in vitro, resembling st...

journal_title：PeerJ

authors： Šneideris T,Baranauskienė L,Cannon JG,Rutkienė R,Meškys R,Smirnovas V

更新日期：2015-09-24 00:00:00

abstract：:Background. A large proportion of natural grasslands around the world is exposed to overgrazing resulting in land degradation and biodiversity loss. Although there is an increasing effort in the promotion of sustainable livestock management, rangeland degradation still occurs because animals' foraging behaviour is hig...

journal_title：PeerJ

authors： di Virgilio A,Morales JM

更新日期：2016-06-21 00:00:00

abstract：Background:The mangrove crab Ucides cordatus is considered a key species for the ecological balance of mangrove forests and a major source of employment and income for traditional crab collectors in Brazil. Several studies evidenced weak genetic variation among populations due to an efficient larval transport. However,...

journal_title：PeerJ

authors： Britto FB,Schmidt AJ,Carvalho AMF,Vasconcelos CCMP,Farias AM,Bentzen P,Diniz FM

更新日期：2018-04-30 00:00:00

abstract：:According to the intelligence-creativity threshold hypothesis, there should be a positive association between intelligence and creative potential up to a certain point, the threshold, after which a further increase in intelligence should have no association with creativity. In the present simulation study, the measure...

journal_title：PeerJ

authors： Sorjonen K,Ingre M,Melin B

更新日期：2019-10-21 00:00:00

abstract：:Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum. This toxin is haemolytic, highly lethal and necrotizing activities...

journal_title：PeerJ

authors： Vázquez-Iglesias L,Estefanell-Ucha B,Barcia-Castro L,Páez de la Cadena M,Álvarez-Chaver P,Ayude-Vázquez D,Rodríguez-Berrocal FJ

更新日期：2017-06-22 00:00:00

abstract：:We investigated population dynamics, breeding pairs, breeding habitat selection, nest density, distance between neighboring nests, nest survival, reproductive success, and recruitment rate for Black-necked Cranes (BNC, Grus nigricollis) during 2013-2015 in Yanchiwan National Nature Reserve (YCW), Gansu, China. Numbers...

journal_title：PeerJ

authors： Zhang L,An B,Shu M,Yang X

更新日期：2017-01-31 00:00:00

abstract：:Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20-40 amino acids, are required for a wide array of biological functions. Despite their diverse and fundamental functions, there has been no comprehensive assessment of their taxonomic distribution, incidence, and associations with org...

journal_title：PeerJ

authors： Jernigan KK,Bordenstein SR

更新日期：2015-01-13 00:00:00

abstract：Background:Methylenetetrahydrofolate reductase (MTHFR) is indispensable for the conversion of homocysteine (Hcy) to methionine. The single nucleotide polymorphism (SNP) of MTHFR gene (rs1801133, C667T) is correlated with decreased enzyme activity that eventually results in elevated plasma Hcy levels. Hyperhomocysteinem...

journal_title：PeerJ

authors： Yuan H,Fu M,Yang X,Huang K,Ren X

更新日期：2020-02-20 00:00:00

abstract：:The marine gastropod, Coralliophila abbreviata, is an obligate corallivore that causes substantial mortality in Caribbean Acropora spp. Considering the imperiled status of Acropora cervicornis and A. palmata, a better understanding of ecological interactions resulting in tissue loss may enable more effective conservat...

journal_title：PeerJ

authors： Bright AJ,Cameron CM,Miller MW

更新日期：2015-09-10 00:00:00

abstract：:This article aimed to give the visibility of Latin American researchers' contributions to the comprehension of COVID-19; our method was a literature review. Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus, SARS-CoV-2, and its disease COVID-19. Therefore, in less than 4 ...

journal_title：PeerJ

authors： Fiesco-Sepúlveda KY,Serrano-Bermúdez LM

更新日期：2020-06-04 00:00:00

abstract：:Climate change will significantly affect plant distribution as well as the quality of medicinal plants. Although numerous studies have analyzed the effect of climate change on future habitats of plants through species distribution models (SDMs), few of them have incorporated the change of effective content of medicina...

journal_title：PeerJ

authors： Guo Y,Wei H,Lu C,Gao B,Gu W

更新日期：2016-10-20 00:00:00

abstract：:We describe a new species of Oligodon from the highlands of the Langbian Plateau, southern Truong Son Mountains, Vietnam, based on morphological and molecular phylogenetic analyses. The new species, Oligodon rostralissp. nov is distinguished from its congeners by the following morphological characters: medium size in ...

journal_title：PeerJ

authors： Nguyen HN,Tran BV,Nguyen LH,Neang T,Yushchenko PV,Poyarkov NA

更新日期：2020-01-06 00:00:00

abstract：:Background. Hand function is essential to a person's self-efficacy and greatly affects quality of life. Adapted utensils with handles of increased diameters have historically been used to assist individuals with arthritis or other hand disabilities for feeding, and other related activities of daily living. To date, mi...

journal_title：PeerJ

authors： McDonald SS,Levine D,Richards J,Aguilar L

更新日期：2016-02-15 00:00:00

abstract：:Recent field trips to Member III of the Naobaogou Formation, Nei Mongol, China yielded new fossil discoveries, increasing our knowledge of the late Permian continental fauna from China. We present here a new large therocephalian, Jiufengia jiai gen. et sp. nov., represented by a partial skull with mandibles and part o...

journal_title：PeerJ

authors： Liu J,Abdala F

更新日期：2019-02-22 00:00:00

abstract：:Sexual differences in size and shape are common across the animal kingdom. The study of sexual dimorphism (SD) can provide insight into the sexual- and natural-selection pressures experienced by males and females in different species. Arachnids are diverse, comprising over 100,000 species, and exhibit some of the more...

journal_title：PeerJ

authors： McLean CJ,Garwood RJ,Brassey CA

更新日期：2018-11-06 00:00:00

abstract：:I used radio-telemetry to track the movements of Mangrove Cuckoos (Coccyzus minor) captured in southwest Florida. Relatively little is known about the natural history of Mangrove Cuckoos, and my goal was to provide an initial description of how individuals use space, with a focus on the size and placement of home rang...

journal_title：PeerJ

authors： Lloyd JD

更新日期：2017-06-30 00:00:00

abstract：:The shifting baseline syndrome describes a gradual lowering of human cognitive baselines, as each generation accepts a lower standard of resource abundance or size as the new norm. There is strong empirical evidence of declining trends of abundance and body sizes of marine fish species reported from docks and markets....

journal_title：PeerJ

authors： Francis FT,Howard BR,Berchtold AE,Branch TA,Chaves LCT,Dunic JC,Favaro B,Jeffrey KM,Malpica-Cruz L,Maslowski N,Schultz JA,Smith NS,Côté IM

更新日期：2019-02-15 00:00:00

abstract：Background:Many fish taxa produce sound in voluntary and in disturbance contexts but information on the full acoustic repertoire is lacking for most species. Yet, this knowledge is critical to enable monitoring fish populations in nature through acoustic monitoring. Methods:In this study we characterized the sounds em...

journal_title：PeerJ

authors： Pereira BP,Vieira M,Pousão-Ferreira P,Candeias-Mendes A,Barata M,Fonseca PJ,Amorim MCP

更新日期：2020-02-24 00:00:00

abstract：:Alzheimer's disease is a multifactorial disorder caused by the interaction of genetic, epigenetic and environmental factors. The formation of cytotoxic oligomers consisting of Aβ peptide is widely accepted as being one of the main key events triggering the development of Alzheimer's disease. Aβ peptide production resu...

journal_title：PeerJ

authors： Parenti N,Del Grosso A,Antoni C,Cecchini M,Corradetti R,Pavone FS,Calamai M

更新日期：2017-04-12 00:00:00

abstract：:Aedes aegypti is the major vector of dengue, yellow fever and chikungunya viruses that put millions of people in endemic countries at risk. Mass rearing of this mosquito is crucial for strategies that use modified insects to reduce vector populations and transmission of pathogens, such as sterile insect technique or p...

journal_title：PeerJ

authors： Gonzales KK,Tsujimoto H,Hansen IA

更新日期：2015-05-05 00:00:00

abstract：:Climatic variables have been the main predictors employed in ecological niche modeling and species distribution modeling, although biotic interactions are known to affect species' spatial distributions via mechanisms such as predation, competition, and mutualism. Biotic interactions can affect species' responses to ab...

journal_title：PeerJ

authors： Simões MVP,Peterson AT

更新日期：2018-12-05 00:00:00

abstract：:N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute liver failure; numerous scientific reports ...

journal_title：PeerJ

authors： Karthivashan G,Kura AU,Arulselvan P,Md Isa N,Fakurazi S

更新日期：2016-07-07 00:00:00

abstract：Background:In this study cull dairy cows from six California dairy herds were sampled seasonally over the course of a year. The objectives were to determine the prevalence of antimicrobial resistant (AMR) Salmonella spp. shed in cull cow feces, and the factors associated with fecal shedding of AMR and multidrug resista...

journal_title：PeerJ

authors： Pereira R,Williams DR,Rossitto P,Adaska J,Okello E,Champagne J,Lehenbauer TW,Li X,Chase J,Nguyen T,Pires AFA,Atwill ER,Aly SS

更新日期：2019-03-21 00:00:00

abstract：Background:Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to resuscitation are very important. The main aim of this study was to analyse whether the level of theoreti...

journal_title：PeerJ

authors： Tíscar-González V,Blanco-Blanco J,Gea-Sánchez M,Rodriguez Molinuevo A,Moreno-Casbas T

更新日期：2019-02-07 00:00:00

abstract：:Myocardial infarction has been carefully studied in numerous experimental models. Most of these models are based on electrophysiological and functional data, and pay less attention to histological discoveries. During the last decade, treatment using advanced therapies, mainly cell therapy, has prevailed from among all...

journal_title：PeerJ

authors： García Gómez-Heras S,Largo C,Larrea JL,Vega-Clemente L,Calderón Flores M,Ruiz-Pérez D,García-Olmo D,García-Arranz M

更新日期：2019-07-22 00:00:00

abstract：:In species that live in one-male groups, resident males monopolize access to a group of females and are assumed to have higher reproductive success than bachelors. We tested this assumption using genetic, demographic, and behavioral data from 8 groups of wild blue monkeys observed over 10 years to quantify reproductio...

journal_title：PeerJ

authors： Roberts SJ,Cords M

更新日期：2015-06-23 00:00:00

abstract：:Insect pollinators provide an essential ecosystem service by transferring pollen to crops and native vegetation. The extent to which pollinator communities vary both spatially and temporally has important implications for ecology, conservation and agricultural production. However, understanding the complex interaction...

journal_title：PeerJ

authors： Willcox BK,Robson AJ,Howlett BG,Rader R

更新日期：2018-10-19 00:00:00

abstract：Background:Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use. Objective:The aim of this study was to evaluate the effect of different doses of amygdalin...

journal_title：PeerJ

authors： Albogami S,Hassan A,Ahmed N,Alnefaie A,Alattas A,Alquthami L,Alharbi A

更新日期：2020-05-21 00:00:00