Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives.

abstract：:Anthropogenic climate change is a significant global driver of species distribution change. Although many species have undergone range expansion at their poleward limits, data on several taxonomic groups are still lacking. A common method for studying range shifts is using species distribution models to evaluate curre...

journal_title：PeerJ

authors： Archis JN,Akcali C,Stuart BL,Kikuchi D,Chunco AJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic approach. Serine-rich Entamoeba histolyticaprotein (SREHP...

journal_title：PeerJ

authors： Manochitra K,Parija SC

更新日期：2017-06-28 00:00:00

abstract：:As more and more prokaryotic sequencing takes place, a method to quickly and accurately analyze this data is needed. Previous tools are mainly designed for metagenomic analysis and have limitations; such as long runtimes and significant false positive error rates. The online tool GenomePeek (edwards.sdsu.edu/GenomePee...

journal_title：PeerJ

authors： McNair K,Edwards RA

更新日期：2015-06-16 00:00:00

abstract：:The Osmundales (Royal Fern order) originated in the late Paleozoic and is the most ancient surviving lineage of leptosporangiate ferns. In contrast to its low diversity today (less than 20 species in six genera), it has the richest fossil record of any extant group of ferns. The structurally preserved trunks and rhizo...

journal_title：PeerJ

authors： Bomfleur B,Grimm GW,McLoughlin S

更新日期：2017-07-11 00:00:00

abstract：:On the purpose of enhancing the forensic efficiency of CODIS STR loci, new STR loci have been gradually discovered and developed into some commercial multiplex systems. Recently, 22 STR loci including 18 non-CODIS STR loci and four CODIS STR loci were investigated in 501 unrelated healthy individuals of Kazakh ethnic ...

journal_title：PeerJ

authors： Chen C,Guo Y,Jin X,Cui W,Wei Y,Fang Y,Lan Q,Kong T,Xie T,Zhu B

更新日期：2019-04-25 00:00:00

abstract：:Recent improvements in next-generation sequencing (NGS) technologies can facilitate the obtainment of mitochondrial genomes. However, it is not clear whether NGS could be effectively used to reconstruct the mitogenome with high gene rearrangement. These high rearrangements would cause amplification failure, and/or ass...

journal_title：PeerJ

authors： Yuan S,Xia Y,Zheng Y,Zeng X

更新日期：2016-12-15 00:00:00

abstract：:Background/Aim. Exercise designed to condition the lumbar extensor musculature is often included in resistance training (RT) programs. It is suggested that deconditioning of this musculature may be linked to low back pain. Thus effective means of conditioning these muscles are of interest to pursue. Evidence suggests ...

journal_title：PeerJ

authors： Steele J,Fitzpatrick A,Bruce-Low S,Fisher J

更新日期：2015-03-31 00:00:00

abstract：Background:Maize (Zea mays L.) is a principal cereal crop cultivated worldwide for human food, animal feed, and more recently as a source of biofuel. However, as a direct consequence of water insufficiency and climate change, frequent occurrences of both biotic and abiotic stresses have been reported in various regions...

journal_title：PeerJ

authors： Kimotho RN,Baillo EH,Zhang Z

更新日期：2019-07-08 00:00:00

abstract：Background:Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification in EMs. However, the relationship between EMT and demethylation modification unde...

journal_title：PeerJ

authors： Wu J,Li X,Huang H,Xia X,Zhang M,Fang X

更新日期：2020-09-15 00:00:00

abstract：:Background. Caesarean birth rates in North America continue to rise, in the absence of benefit for mothers and babies. One reason may be that hospitalized labouring women spend most of their labours in recumbent or semi-recumbent positions. Although hands-and-knees position has theoretical advantages, efforts to encou...

journal_title：PeerJ

authors： Hodnett ED,Stremler R,Halpern SH,Weston J,Windrim R

更新日期：2013-02-12 00:00:00

abstract：Background:This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods:We retrospectively analyzed consecutive ischemic stroke patients who wer...

journal_title：PeerJ

authors： Lin TC,Lin YK,Chen CI,Chan L,Chi NF,Yuan RY,Sheu JJ,Wei CR,Tsai JP,Yeh TH

更新日期：2018-11-23 00:00:00

abstract：Background:Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system and alteration in interaction molecules. Therefore, various thera...

journal_title：PeerJ

authors： Winnicki W,Pichler P,Mechtler K,Imre R,Steinmacher I,Sengölge G,Knafl D,Beilhack G,Wagner L

更新日期：2019-12-16 00:00:00

abstract：Background:Variation in management across elephant camps likely has differential effects on the well-being of elephants. Methods:This study calculated body condition, foot health and skin wound scores (WSs) for 122 elephants from 15 elephant camps in Chiang Mai province, and examined relationships to management factor...

journal_title：PeerJ

authors： Bansiddhi P,Nganvongpanit K,Brown JL,Punyapornwithaya V,Pongsopawijit P,Thitaram C

更新日期：2019-04-25 00:00:00

abstract：:Sanderlings (Calidris alba) are long-distance migratory shorebirds with a non-breeding range that spans temperate and tropical coastal habitats. Breeding in the High Arctic combined with non-breeding seasons in the tropics necessitate long migrations, which are energetically demanding. On an annual basis, the higher e...

journal_title：PeerJ

authors： Grond K,Ntiamoa-Baidu Y,Piersma T,Reneerkens J

更新日期：2015-08-11 00:00:00

abstract：:Pantoea stewartii subsp. stewartii is a bacterial phytopathogen that causes Stewart's wilt disease in corn. It uses quorum sensing to regulate expression of some genes involved in virulence in a cell density-dependent manner as the bacterial population grows from small numbers at the initial infection site in the leaf...

journal_title：PeerJ

authors： Packard H,Kernell Burke A,Jensen RV,Stevens AM

更新日期：2017-04-27 00:00:00

abstract：:The currently-accepted dogma when analysing human Alu transposable elements is that 'young' Alu elements are found in low GC regions and 'old' Alus in high GC regions. The correlation between high GC regions and high gene frequency regions make this observation particularly difficult to explain. Although a number of s...

journal_title：PeerJ

authors： Hellen EH,Brookfield JF

更新日期：2013-05-21 00:00:00

abstract：:The vibrating reed frequency meter, originally employed by Békésy and later by Wilson as a cochlear model, uses a set of tuned reeds to represent the cochlea's graded bank of resonant elements and an elastic band threaded between them to provide nearest-neighbour coupling. Here the system, constructed of 21 reeds prog...

journal_title：PeerJ

authors： Bell A,Wit HP

更新日期：2015-10-13 00:00:00

abstract：:Changes in soil bacterial communities, which are crucial for the assessment of ecological restoration in Chinese plantations, have never been studied in the "Three North Shelterbelt" project in the semi-arid areas. We used high-throughput sequencing of the 16S rDNA gene to investigate the soil bacterial community dive...

journal_title：PeerJ

authors： Deng J,Zhang Y,Yin Y,Zhu X,Zhu W,Zhou Y

更新日期：2019-06-25 00:00:00

abstract：:Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed to one round of phototoxic treatment with adult zebr...

journal_title：PeerJ

authors： Ranski AH,Kramer AC,Morgan GW,Perez JL,Thummel R

更新日期：2018-09-20 00:00:00

abstract：:The structural and material properties of insect cuticle remain largely unexplored, even though they comprise the majority (approximately 80%) of animals. Insect cuticle serves many functions, including protection against predatory attacks, which is especially beneficial to species failing to employ effective running ...

journal_title：PeerJ

authors： Clark AJ,Triblehorn JD

更新日期：2014-07-31 00:00:00

abstract：:The expansion of moose into southern British Columbia caused the decline and extirpation of woodland caribou due to their shared predators, a process commonly referred to as apparent competition. Using an adaptive management experiment, we tested the hypothesis that reducing moose to historic levels would reduce appar...

journal_title：PeerJ

authors： Serrouya R,McLellan BN,van Oort H,Mowat G,Boutin S

更新日期：2017-08-29 00:00:00

abstract：:Conservation initiatives to protect and restore valued species communities in human-dominated landscapes face challenges linked to their potential costs. Conservation easements on private land may represent a cost-effective alternative to land purchase, but long-term costs to monitor and enforce easements, or defend l...

journal_title：PeerJ

authors： Schuster R,Arcese P

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) transmission has been reported in 67 countries/territories in the Oceania region and the Americas since 2015, prompting the World Health Organization (WHO) to declare ZIKV as a Public Health Emergency of International Concern in February 2016, due to its strong association with medical comp...

journal_title：PeerJ

authors： Hsieh YH

更新日期：2017-03-21 00:00:00

abstract：:We describe a new iguanodontian ornithopod, Choyrodon barsboldi gen. et sp. nov. from the Albian-aged Khuren Dukh Formation of Mongolia based on several partial skeletons interpreted to represent a subadult growth stage based on osteohistological features. This new taxon is diagnosed by many autapomorphies of the maxi...

journal_title：PeerJ

authors： Gates TA,Tsogtbaatar K,Zanno LE,Chinzorig T,Watabe M

更新日期：2018-08-03 00:00:00

abstract：:As coral reefs continue to decline globally, coral restoration practitioners have explored various approaches to return coral cover and diversity to decimated reefs. While branching coral species have long been the focus of restoration efforts, the recent development of the microfragmentation coral propagation techniq...

journal_title：PeerJ

authors： Koval G,Rivas N,D'Alessandro M,Hesley D,Santos R,Lirman D

更新日期：2020-10-02 00:00:00

abstract：:Neem (Azadirachta indica A. Juss) is one of the most versatile tropical evergreen tree species known in India since the Vedic period (1500 BC-600 BC). Neem tree is a rich source of limonoids, having a wide spectrum of activity against insect pests and microbial pathogens. Complex tetranortriterpenoids such as azadirac...

journal_title：PeerJ

authors： Kuravadi NA,Yenagi V,Rangiah K,Mahesh HB,Rajamani A,Shirke MD,Russiachand H,Loganathan RM,Shankara Lingu C,Siddappa S,Ramamurthy A,Sathyanarayana BN,Gowda M

更新日期：2015-08-06 00:00:00

abstract：BACKGROUND:Mycobacterium avium subsp. hominissuis (MAH) is an emerging opportunistic human pathogen. It can cause pulmonary infections, lymphadenitis and disseminated infections in immuno-compromised patients. In addition, MAH is widespread in the environment, since it has been isolated from water, soil or dust. In rec...

journal_title：PeerJ

authors： Sanchini A,Dematheis F,Semmler T,Lewin A

更新日期：2017-01-03 00:00:00

abstract：:The common bottlenose dolphin, Tursiops truncatus, is widely distributed along the western coast of South America. In Ecuador, a resident population of bottlenose dolphins inhabits the inner estuarine area of the Gulf of Guayaquil located in the southwestern part of the country and is under threat from different human...

journal_title：PeerJ

authors： Bayas-Rea RLÁ,Félix F,Montufar R

更新日期：2018-04-09 00:00:00

abstract：Background:Morphological differentiation between populations resulting from local adaptations to environmental conditions is likely to be more pronounced in populations with increasing genetic isolation. In a previous study a positive clinal variation in body size was observed in isolated Roesel's bush-cricket, Metriop...

journal_title：PeerJ

authors： Kaňuch P,Kiehl B,Cassel-Lundhagen A,Laugen AT,Low M,Berggren Å

更新日期：2020-10-22 00:00:00

abstract：:To understand the mechanism of photosynthetic inhibition and generation of reactive oxygen species (ROS) in Symbiodinium types under stress, chemicals such as dichlorophenyl dimethylurea (DCMU) are widely used. Moreover, DCMU and recently menthol were used to generate aposymbiotic cnidarian hosts. While the effects of...

journal_title：PeerJ

authors： Wang JT,Keshavmurthy S,Chu TY,Chen CA

更新日期：2017-10-02 00:00:00