Effect of two periodontal treatment modalities in patients with uncontrolled type 2 diabetes mellitus: A randomized clinical trial.


AIM:To evaluate the impact of two non-surgical periodontal treatment modalities on metabolic and periodontal clinical parameters in subjects with type 2 diabetes mellitus (T2DM) and poor glycaemic control and chronic periodontitis. MATERIAL AND METHODS:A randomized controlled clinical trial was conducted. Ninety-three T2DM subjects with glycosylated haemoglobin (HbA1c) > 7% were randomly assigned to one of two groups receiving scaling with root planing in multiple sessions quadrant-by-quadrant (Q by Q) or within 24 hr (one stage). Periodontal parameters, HbA1c, glycaemia blood levels (FPG) and C-reactive protein (CRP) values were assessed at baseline and at 3 and 6 months post-therapy. RESULTS:At 6 months, HbA1c had decreased by 0.48% in the Q by Q group and by 0.18% in the one-stage group (p = 0.455). After therapy, subjects with an initial HbA1c < 9% showed an increase of 0.31% (p = 0.145), compared with a decrease of 0.88% (p = 0.006) in those with an initial HbA1c ≥ 9%. Periodontal parameters improved significantly (p < 0.0001) post-therapy, with similar results for both treatment modalities. CONCLUSION:Periodontal therapy had the greatest impact on HbA1c reduction on patients with an HbA1c > 9% regardless of treatment modality. Both modalities resulted in significant improvements in periodontal parameters.


J Clin Periodontol


Quintero AJ,Chaparro A,Quirynen M,Ramirez V,Prieto D,Morales H,Prada P,Hernández M,Sanz A




Has Abstract


2018-09-01 00:00:00












  • Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review.

    abstract:BACKGROUND:Subantimicrobial dose doxycycline (SDD--20 mg doxycycline twice daily) is indicated as an adjunctive treatment for periodontitis. Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive enzymes in periodontal disease. Current understanding of periodontal pathogenesis sugge...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Preshaw PM,Hefti AF,Jepsen S,Etienne D,Walker C,Bradshaw MH

    更新日期:2004-09-01 00:00:00

  • The periodontal health component of the Renal Impairment In Secondary Care (RIISC) cohort study: a description of the rationale, methodology and initial baseline results.

    abstract:INTRODUCTION:Chronic kidney disease (CKD) is associated with significant morbidity and mortality. There is a need to identify novel and modifiable risk factors in such patients. The periodontal component of the Renal Impairment In Secondary Care (RIISC) study aims to evaluate the association between chronic periodontit...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章


    authors: Sharma P,Dietrich T,Sidhu A,Vithlani V,Rahman M,Stringer S,Jesky M,Kaur O,Ferro C,Cockwell P,Chapple IL

    更新日期:2014-07-01 00:00:00

  • The association between missing teeth and non-alcoholic fatty liver disease in adults.

    abstract:AIMS:Long-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Qiao F,Fu K,Zhang Q,Liu L,Meng G,Wu H,Xia Y,Bao X,Gu Y,Shi H,Sun S,Wang X,Zhou M,Jia Q,Song K,Niu K

    更新日期:2018-08-01 00:00:00

  • Gingival bleeding after chlorhexidine mouthrinses.

    abstract::During a clinical trial for evaluating the antiplaque effect of two flavoured chlorhexidine rinses, the observation was made that bleeding after gentle massage of the gingival margin occurred more often after chemical than after mechanical oral hygiene measures. In order to ascertain the validity of this unexpected ob...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Ainamo J,Asikainen S,Paloheimo L

    更新日期:1982-07-01 00:00:00

  • A socio-ecologic model for periodontal diseases.

    abstract::A socio-ecologic conceptual model for periodontal diseases has been proposed. The model, which includes 4 items: health-care organization, human biology, behavioral factors, and environment, has been tested on a random-sample of 50-year-old Oslo citizens. The investigation is based on a clinical examination as well as...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Hansen BF,Bjertness E,Grønnesby JK

    更新日期:1993-09-01 00:00:00

  • In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics.

    abstract:BACKGROUND/AIMS:Periodontal infections with Actinobacillus actinomycetemcomitans seem to be refractory to conventional therapy. The aim of the present study was to test the in vitro susceptibilities of A. actinomycetemcomitans strains to a panel of seven orally administrable antibiotics. METHODS:A total of 60 isolates...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Müller HP,Holderrieth S,Burkhardt U,Höffler U

    更新日期:2002-08-01 00:00:00

  • Microbiology of destructive periodontal disease in adolescent patients with congenital neutropenia. A report of 3 cases.

    abstract:BACKGROUND, AIMS:Congenital neutropenia is one condition that may predispose for destructive periodontal disease at a young age. In this report, we describe the microbiology of 3 adolescent patients with congenital neutropenia two of whom suffered from severe periodontitis. METHOD:Microbiological testing of the parent...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: van Winkelhoff AJ,Schouten-van Meeteren AY,Baart JA,Vandenbroucke-Grauls CM

    更新日期:2000-11-01 00:00:00

  • Comparative 3D micro-CT and 2D histomorphometry analysis of dental implant osseointegration in the maxilla of minipigs.

    abstract:AIM:The bone implant contact (BIC) has traditionally been evaluated with histological methods. Thereupon, strong correlations of two-dimensional (2D) BIC have been detected between μCT and destructive histology. However, due to the high intra-sample variability in BIC values, one histological slice is not sufficient to...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Bissinger O,Probst FA,Wolff KD,Jeschke A,Weitz J,Deppe H,Kolk A

    更新日期:2017-04-01 00:00:00

  • Chemotherapeutic agents for controlling plaque and gingivitis.

    abstract::There has been a vigorous search for many years for chemical agents that could supplement or even supplant patient-dependent mechanical plaque control and thus reduce or prevent oral disease. 5 categories of agents or approaches have been considered: (1) broad spectrum antiseptics, (2) antibiotics aimed at specific ba...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Mandel ID

    更新日期:1988-09-01 00:00:00

  • Patient-reported outcomes and aesthetic evaluation of root coverage procedures: a 12-month follow-up of a randomized controlled clinical trial.

    abstract:AIM:To assess patient-reported outcome measures (PROMs), aesthetics and stability of root coverage procedures from a previous 6-month RCT after 1 year. MATERIAL & METHODS:Forty-five patients (90 recessions) had received a coronally advanced flap (CAF = control) only or a xenogeneic collagen matrix in addition (CAF + C...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Stefanini M,Jepsen K,de Sanctis M,Baldini N,Greven B,Heinz B,Wennström J,Cassel B,Vignoletti F,Sanz M,Jepsen S,Zucchelli G

    更新日期:2016-12-01 00:00:00

  • Phenytoin induced gingival overgrowth in institutionalized epileptics.

    abstract::In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique. Lesion severity was then compared statistically to other clinical and laboratory parameters. Positive c...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Hassell T,O'Donnell J,Pearlman J,Tesini D,Murphy T,Best H

    更新日期:1984-04-01 00:00:00

  • Implants and infections with special reference to oral bacteria.

    abstract::Osseointegration or bony anchorage of oral implants was first described by Brånemark and coworkers. This type of connection between the titanium oxide layer and the bone gives stable long-term results for the implants in function. Fibrous tissue interphase between implant and bone will allow mobility which will gradua...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Haanaes HR

    更新日期:1990-08-01 00:00:00

  • The osteoclast and periodontitis.

    abstract::The osteoclast may play an important rŏle in the variable rate of osseous destruction seen in periodontitis. Current understanding of various aspects of the osteoclast may help explain this fact. This review paper will first look at two theories of cell origin of the osteoclast: the multipotential osteoprogenitor cell...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Sterrett JD

    更新日期:1986-04-01 00:00:00

  • The effect of periodontal status and occlusal support on masticatory performance: the Suita study.

    abstract:AIM:In this study, we investigated the effect of differences in periodontal status in the masticatory performance of dentate subjects with the same occlusal supporting area. MATERIALS AND METHODS:The subjects of the analysis were classified into those of Eichner A1-3 (n = 1094) and Eichner B1-4 (n = 529). Subjects' pe...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Kosaka T,Ono T,Yoshimuta Y,Kida M,Kikui M,Nokubi T,Maeda Y,Kokubo Y,Watanabe M,Miyamoto Y

    更新日期:2014-05-01 00:00:00

  • The width of radiologically-defined attached gingiva over permanent teeth in children.

    abstract::Several authors have determined clinically the width of attached gingiva (AG) over the deciduous and early permanent dentitions in children. They have noticed that when comparing the width of AG over deciduous teeth to the width of AG over the succeeding newly erupted permanent teeth, a clear diminishing in AG can be ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Saario M,Ainamo A,Mattila K,Ainamo J

    更新日期:1994-11-01 00:00:00

  • Gingival recession in smokers and non-smokers with minimal periodontal disease.

    abstract:BACKGROUND/AIMS:Smoking is a major risk factor for destructive periodontal disease. There is limited information with regard to effects of smoking in subjects with minimal periodontal destruction. The aim of the present investigation was to assess the development of gingival recession in young adult smokers and non-smo...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Müller HP,Stadermann S,Heinecke A

    更新日期:2002-02-01 00:00:00

  • Gingivitis in the deciduous and permanent dentition. An experimental study in the dog.

    abstract::The present investigation was performed in order to study the reaction of the gingiva in the deciduous and permanent dentition of dogs to 3 weeks of plaque accumulation. The study was carried out in 10 beagles, divided into 2 groups of 5 dogs each; group I and group II. When the dogs of group I were 10 weeks old, a me...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Berglundh T,Liljenberg B,Ericsson I,Lindhe J

    更新日期:1989-08-01 00:00:00

  • No detrimental effect of fibrin glue on the regeneration of intrabony defects. A controlled clinical trial.

    abstract::This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators, 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cortellini P,Pini Prato GP,Tonetti MS

    更新日期:1995-09-01 00:00:00

  • A radiographic survey of periodontal conditions in Greece.

    abstract::The present study used radiographic assessments to evaluate the pattern of destructive periodontal disease ina rural and an urban sample of 25-64 year old Greek adults. The rural sample (A) comprised 190 subjects and the urban sample (B) 400 subjects. 13% of the subjects in sample A and 8% in sample B were edentulous....

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Diamanti-Kipioti A,Afentoulidis N,Moraitaki-Tsami A,Lindhe J,Mitsis F,Papapanou PN

    更新日期:1995-05-01 00:00:00

  • Periodontal therapy by local delivery of tetracycline.

    abstract::The present investigation assessed the feasibility of treating periodontal disease by controlled delivery of antibacterial agents from within periodontal pockets. Tetracycline-filled hollow fibers placed in the gingival sulcus were shown to have a dramatic effect both on the periodontal microflora and clinical manifes...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Goodson JM,Haffajee A,Socransky SS

    更新日期:1979-04-01 00:00:00

  • Application of matched pair procedures to site-specific data in periodontal research.

    abstract::Application of standard statistical procedures to site-specific data in periodontal research is invalid unless site-to-site dependencies are accounted for. In this paper, we present the adjustments required for valid application of matched pair procedures, including the paired t-test and McNemar's chi 2 test for corre...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Donner A,Eliasziw M

    更新日期:1991-11-01 00:00:00

  • Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats.

    abstract:AIM:To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. MATERIALS AND METHODS:Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Levi YLAS,Novais GS,Dias RB,Andraus RAC,Messora MR,Neto HB,Ervolino E,Santinoni CS,Maia LP

    更新日期:2018-09-01 00:00:00

  • Plasma TGF-beta1 as a risk factor for gingival overgrowth.

    abstract:BACKGROUND AND AIMS:Induction of the pro-fibrotic growth factor TGF-beta1 has been suggested as a possible mechanism through which immunosuppressant drugs may induce gingival overgrowth. This study aims to investigate plasma levels of TGF-beta1 and relate them to the development and severity of gingival overgrowth in i...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Ellis JS,Morgan CL,Kirby JA,Taylor JJ,Thomason JM

    更新日期:2004-10-01 00:00:00

  • Association between bacteriophage-infected Actinobacillus actinomycetemcomitans and rapid periodontal destruction.

    abstract::Actinobacillus actinomycetemcomitans was isolated from periodontal pockets in a patient suffering from prepubertal periodontitis. Electron microscopy revealed 3 different groups of bacteriophages in filtrates of subgingival plaque from all the active periodontal lesions. Phage infected A. actinomycetemcomitans in this...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Preus HR,Olsen I,Namork E

    更新日期:1987-04-01 00:00:00

  • Prognostic value of the periodontal risk assessment in patients with aggressive periodontitis.

    abstract:OBJECTIVES:Aim of the study was to evaluate the predictive value of the modified periodontal risk assessment (PRA) in patients with aggressive periodontitis (AgP) for the first time. MATERIAL AND METHODS:A total of 86 Patients with AgP were re-examined 5-17 years after active periodontal treatment. Risk profile accord...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Meyer-Bäumer A,Pritsch M,Cosgarea R,El Sayed N,Kim TS,Eickholz P,Pretzl B

    更新日期:2012-07-01 00:00:00

  • Serum lipids modify periodontal infection - C-reactive protein association.

    abstract:AIM:To investigate whether low-grade inflammation-related factors such as serum low-density (LDL-C) and high-density lipoprotein cholesterol (HDL-C) modify the association between periodontal infection and C-reactive protein. MATERIAL AND METHODS:This study was based on a subpopulation of the Health 2000 Survey, which...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Haro A,Saxlin T,Suominen AL,Ylöstalo P,Leiviskä J,Tervonen T,Knuuttila M

    更新日期:2012-09-01 00:00:00

  • Local delivery of chemotherapeutic agents in periodontal therapy: has its time arrived?

    abstract::The concept of locally delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally delivered chemotherapeutic agents in periodontal therapy are either currently available or under investigation. Clinical efficacy derives ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Finkelman RD,Williams RC

    更新日期:1998-11-01 00:00:00

  • Effect of root surface alterations on periodontal healing. II. Citric acid treatment of the denuded root.

    abstract::A companion study reported that new connective tissue attachment did not occur to a surgically denuded root surface when transplanted into a normal periodontium. It was the purpose of this study to evaluate periodontal healing adjacent to a citric acid treated denuded root surface. In four squirrel monkeys, 12 teeth w...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Polson AM,Proye MP

    更新日期:1982-11-01 00:00:00

  • A systematic review of the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush.

    abstract:OBJECTIVE:To assess the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush with respect to the level of plaque and gingivitis in controlled studies of at least 6 months duration. SEARCH: Medline-PubMed up to and including September 2004. RESULTS:Out of 3223 ti...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,meta分析,评审


    authors: van der Weijden GA,Hioe KP

    更新日期:2005-01-01 00:00:00

  • Effects of transforming growth factor-beta and platelet-derived growth factor on human gingival fibroblasts grown in serum-containing and serum-free medium.

    abstract::Both transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) have been shown to affect cell proliferation in vitro. The hypothesis being tested was that the effects of the 2 cytokines would be modulated by the presence of serum in the medium. Gingival fibroblasts, obtained from periodontal...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Anderson TJ,Lapp CA,Billman MA,Schuster GS

    更新日期:1998-01-01 00:00:00