当前位置： SCI文献检索 > Journal of the Mechanical Behavior of Biomedical Materials期刊下所有文献 > Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair.

Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair.

Abstract：

:Meniscal injury is typically treated surgically via partial meniscectomy, which has been shown to cause cartilage degeneration in the long-term. Consequently, research has focused on meniscal prevention and replacement. However, none of the materials or implants developed for meniscal replacement have yet achieved widespread acceptance or demonstrated conclusive chondroprotective efficacy. A redesigned silk fibroin scaffold, which already displayed promising results regarding biocompatibility and cartilage protection in a previous study, was characterised in terms of its biomechanical, structural and biological functionality to serve as a potential material for permanent partial meniscal replacement. Therefore, different quasi-static but also dynamic compression tests were performed. However, the determined compressive stiffness (0.56 ± 0.31 MPa and 0.30 ± 0.12 MPa in relaxation and creep configuration, respectively) was higher in comparison to the native meniscal tissue, which could potentially disturb permanent integration into the host tissue. Nevertheless, µ-CT analysis met the postulated requirements for partial meniscal replacement materials in terms of the microstructural parameters, like mean pore size (215.6 ± 10.9 µm) and total porosity (80.1 ± 4.3%). Additionally, the biocompatibility was reconfirmed during cell culture experiments. The current study provides comprehensive mechanical and biological data for the characterisation of this potential replacement material. Although some further optimisation of the silk fibroin scaffold may be advantageous, the silk fibroin scaffold showed sufficient biomechanical competence to support loads already in the early postoperative phase.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Warnecke D,Stein S,Haffner-Luntzer M,de Roy L,Skaer N,Walker R,Kessler O,Ignatius A,Dürselen L

doi

10.1016/j.jmbbm.2018.06.041

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

314-324

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(18)30392-8

journal_volume

pub_type

杂志文章

在线工具

Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair.